Apoptosis modulation by HSP70 (Canis familiaris)

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STRESSInhibitionFAS-LigandCELL SURVIVALDegradation ofIk alpha(activation of NFkB)TNF-alphaAPOPTOSISDegradation of proteinsApoptosomeActivationNF-kBpathwayInhibitionInhibitionMitochondriaProteasomeInhibitionMAPK10CYCSCASP7BIDCASP8CASP3HSPA1AFADDHSPA1AFASCASP2CASP8HSPA1AAIFM1MAP3K1TNFRSF1ARIPK1CASP9NFKB1FADDCYCSAPAF1CASP6


Description

This pathway summarizes the various ways by which HSP70 proteins can inhibit apoptosis.

Comments

GenMAPP notes 
References of HSP70 and inhibition of apoptosis:

1. Garrido C, Schmitt E, Cande C, Vahsen N, Parcellier A, Kroemer G. HSP27 and HSP70: potentially oncogenic apoptosis inhibitors. Cell Cycle. 2003 Nov-Dec;2(6):579-84. PMID: 14512773 [PubMed - in process]
2. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol. 2000 Oct;20(19):7146-59. PMID: 10982831 [PubMed - indexed for MEDLINE]
3. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol. 2000 Aug;2(8):476-83. PMID: 10934467 [PubMed - indexed for MEDLINE]
4. Schett G, Steiner CW, Groger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G. Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. FASEB J. 1999 May;13(8):833-42. PMID: 10224227 [PubMed - indexed for MEDLINE]
5. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett. 1998 Oct 30;438(1-2):1-4. Review. PMID: 9821948 [PubMed - indexed for MEDLINE]
6. Jaattela M, Wissing D, Kokholm K, Kallunki T, Egeblad M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.
EMBO J. 1998 Nov 2;17(21):6124-34. PMID: 9799222 [PubMed - indexed for MEDLINE]
7. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci P. The life span determinant p66Shc localizes to mitochondria where it associates with mtHsp70 and regulates trans-membrane potential. J Biol Chem. 2004 Apr 12 [Epub ahead of print] 
PMID: 15078873 [PubMed - as supplied by publisher]
8. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene. 2003 Oct 2;22(43):6669-78. 
PMID: 14555980 [PubMed - indexed for MEDLINE]

GenMAPP remarks 
Right click for info. Adapted from rat by GenMAPP
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP384(r29910) with a 78% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
117079view14:49, 16 May 2021EweitzModified title
98543view20:51, 14 September 2018KhanspersModified description
87012view14:45, 15 July 2016MkutmonOntology Term : 'apoptotic cell death pathway' added !
72022view12:43, 24 October 2013Mkutmonfixed unconnected lines
68553view22:39, 5 July 2013MaintBotUpdated to 2013 gpml schema
40710view21:51, 1 March 2011MaintBotRemoved redundant pathway information and comments
32274view13:06, 15 August 2009MaintBotFixed text labels
31809view12:20, 14 August 2009MaintBotFixed group labels
31302view20:11, 13 August 2009MaintBotFixed text labels
30768view23:15, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AIFM1GeneProduct481048 (Entrez Gene) Apoptosis Inducing Factor
APAF1GeneProduct482620 (Entrez Gene)
BIDGeneProduct486607 (Entrez Gene)
CASP2GeneProduct482737 (Entrez Gene)
CASP3GeneProduct403567 (Entrez Gene)
CASP6GeneProduct487899 (Entrez Gene)
CASP7GeneProduct486896 (Entrez Gene)
CASP8GeneProduct488473 (Entrez Gene)
CASP9GeneProduct487432 (Entrez Gene)
CYCSGeneProduct475258 (Entrez Gene)
FADDGeneProduct
FASGeneProduct486469 (Entrez Gene)
HSPA1AGeneProduct
MAP3K1GeneProduct478061 (Entrez Gene)
MAPK10GeneProduct478464 (Entrez Gene)
NFKB1GeneProduct442859 (Entrez Gene)
RIPK1GeneProduct488195 (Entrez Gene)
TNFRSF1AGeneProduct403634 (Entrez Gene)

Annotated Interactions

No annotated interactions
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