Eicosanoid synthesis (Canis familiaris)

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115-Hydroperoxy Eicosatetraenoic Acid12-Hydroperoxy Eicosatetraenoic AcidProstaglandin E2Thromboxane A3Cell Membrane6-Keto-Prostaglandin F2-alpha12-HETEPTGDSALOX15B5-HPETEALOX15LTA4HLeukotriene E4PLA2G6Thromboxane A25-HETEALOX15ALOX5APThromboxane B2Prostaglandin F2aPeroxidase?PTGS2Peroxidase?PNPLA8LTC4SArachidonic acidGGT1PLA2G615-HETEProstaglandin H2PTGS1PGD2 11-ketoreducALOX5Leukotriene A4Leukotriene D4ALOX5PGE2 9-ketoreducLeukotriene B4Prostaglandin D2PTGES2ALOX12PTGESProstaglandin I2PTGISALOX5APTBXAS1PLA2G2ALeukotriene C4Peroxidase?DPEP1


Description

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP167(r21031) with a 70% conversion rate.

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Ontology Terms

 

Bibliography

  1. Funk CD; ''''; , PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117446view10:52, 21 May 2021EweitzModified title
106031view11:55, 16 August 2019MaintBotHMDB identifier normalization
89461view13:12, 15 September 2016Mkutmonremove space in ontology term id
71490view19:19, 17 October 2013MaintBotAutomated update of data sources
68599view23:25, 5 July 2013MaintBotUpdated to 2013 gpml schema
67182view10:17, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
62729view03:19, 2 May 2013MaintBotUpdated UniProt data source
40758view21:55, 1 March 2011MaintBotRemoved redundant pathway information and comments
35480view12:15, 12 February 2010Thomasadded literature
35475view12:13, 12 February 2010ThomasModified description
34030view18:48, 9 December 2009MaintBotAutomatic update of empty xrefs
31722view11:55, 14 August 2009MaintBotFixed group labels
30659view22:36, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
12-HETEMetabolite
15-HETEMetabolite
5-HETEMetabolite
5-HPETEMetaboliteHMDB0001193 (HMDB)
ALOX12GeneProduct479476 (Entrez Gene)
ALOX15GeneProduct489458 (Entrez Gene)
ALOX15BGeneProduct489485 (Entrez Gene)
ALOX5GeneProduct477753 (Entrez Gene)
ALOX5APGeneProduct477323 (Entrez Gene)
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
DPEP1GeneProduct479611 (Entrez Gene)
GGT1GeneProduct486400 (Entrez Gene)
LTA4HGeneProduct482611 (Entrez Gene)
LTC4SGeneProduct607316 (Entrez Gene)
Leukotriene A4MetaboliteHMDB0001337 (HMDB)
Leukotriene B4MetaboliteHMDB0001085 (HMDB)
Leukotriene C4MetaboliteHMDB0001198 (HMDB)
Leukotriene D4MetaboliteHMDB0003080 (HMDB)
Leukotriene E4MetaboliteHMDB0002200 (HMDB)
PGD2 11-ketoreducGeneProduct
PGE2 9-ketoreducGeneProduct
PLA2G2AGeneProduct
PLA2G6GeneProduct481256 (Entrez Gene)
PNPLA8GeneProduct475880 (Entrez Gene)
PTGDSGeneProduct403740 (Entrez Gene)
PTGES2GeneProduct609101 (Entrez Gene)
PTGESGeneProduct480698 (Entrez Gene)
PTGISGeneProduct485919 (Entrez Gene)
PTGS1GeneProduct403544 (Entrez Gene)
PTGS2GeneProduct442942 (Entrez Gene)
Peroxidase?GeneProduct
Prostaglandin D2MetaboliteHMDB0001403 (HMDB)
Prostaglandin F2aMetaboliteHMDB0001139 (HMDB)
Prostaglandin H2MetaboliteHMDB0001381 (HMDB)
Prostaglandin I2MetaboliteHMDB0001335 (HMDB)
TBXAS1GeneProduct482771 (Entrez Gene)
Thromboxane A2MetaboliteHMDB0001452 (HMDB)
Thromboxane B2MetaboliteHMDB0003252 (HMDB)

Annotated Interactions

No annotated interactions
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