Drug induction of bile acid pathway (Bos taurus)
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Hepatic Uptake
Hepatocyte
Sensing
Bile Acids
BAAT
Cholesterol
ABCB1
NR1H4
SLC51A
BA-R
Clozapine
Troglitazone
Glycocholic acid
SLCO1B1
Cyclosporin
Ezetimibe
CYP7A1
SULT2A1
Tetrahydrocortisone
CYP3A4
SLC10A1
Chlorpromazine
Metabolites
Bile
Bile Duct
Taurocholic acid
Bilirubin
Isoursodeoxycholic acid
Deoxycholic acid
VDR
NR1I3
NR1I2
Methylprednisolone
Cimetidine
SLC51B
ABCC4
ABCB11
ABCC3
ABCC2
Phospholipids
Digoxin
Clarithromyci
Erythromycin
Silybin
Glyburide
Tacrolimus
Trabectedin
Phomin
Colchicine
Ranitidine
Oxiglutatione
Synthesis
Conjugation
Secretion
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP2289(78511)
with a 88.0% conversion rate.
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Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
NGP E-Magazine; ''Mechanistic Disease Modeling''; http://www.ngpharma.com/article/Mechanistic-Disease-Modeling/, 2012
History
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Compare
Revision
Action
Time
User
Comment
128628
view
03:02, 17 February 2024
Eweitz
Economize layout, standardize case
128624
view
02:02, 17 February 2024
Eweitz
Ontology Term : 'hepatocyte' added !
120497
view
07:28, 9 December 2021
Egonw
Replaced an old PubChem CID with the new one
117499
view
11:04, 21 May 2021
Eweitz
Modified title
105930
view
11:46, 16 August 2019
MaintBot
HMDB identifier normalization
87244
view
09:57, 20 July 2016
Susan
Ontology Term : 'bile acid signaling pathway' added !
87243
view
09:57, 20 July 2016
Susan
Ontology Term : 'drug pathway' added !
80889
view
15:30, 30 June 2015
Mkutmon
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ABCB11
GeneProduct
ENSBTAG00000026885 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8647
ABCB1
GeneProduct
ENSBTAG00000005997 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5243
ABCC2
GeneProduct
ABCC3
GeneProduct
ABCC4
GeneProduct
ENSBTAG00000046611 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10257
BA-R
Metabolite
BAAT
GeneProduct
ENSBTAG00000025760 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:570
Bile Acids
Metabolite
CHEBI:3098 (ChEBI)
Bilirubin
Metabolite
HMDB0000054 (HMDB)
CYP3A4
GeneProduct
ENSBTAG00000047379 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1576
CYP7A1
GeneProduct
ENSBTAG00000005287 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1581
Chlorpromazine
Metabolite
2726 (PubChem-compound)
Cholesterol
Metabolite
HMDB0000067 (HMDB)
Cimetidine
Metabolite
2756 (PubChem-compound)
Clarithromyci
Metabolite
84029 (PubChem-compound)
Clozapine
Metabolite
2818 (PubChem-compound)
Colchicine
Metabolite
6167 (PubChem-compound)
Cyclosporin
Metabolite
5284373 (PubChem-compound)
Deoxycholic acid
Metabolite
HMDB0000626 (HMDB)
Digoxin
Metabolite
HMDB0001917 (HMDB)
Erythromycin
Metabolite
12560 (PubChem-compound)
Ezetimibe
Metabolite
150311 (PubChem-compound)
Glyburide
Metabolite
3488 (PubChem-compound)
Glycocholic acid
Metabolite
HMDB0000138 (HMDB)
Isoursodeoxycholic acid
Metabolite
HMDB0000686 (HMDB)
Methylprednisolone
Metabolite
6741 (PubChem-compound)
NR1H4
GeneProduct
ENSBTAG00000013596 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9971
NR1I2
GeneProduct
ENSBTAG00000019557 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8856
NR1I3
GeneProduct
ENSBTAG00000009215 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9970
Oxiglutatione
Metabolite
65359 (PubChem-compound)
Phomin
Metabolite
5311281 (PubChem-compound)
Phospholipids
Metabolite
CHEBI:16247 (ChEBI)
Ranitidine
Metabolite
HMDB0001930 (HMDB)
SLC10A1
GeneProduct
ENSBTAG00000001881 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6554
SLC51A
GeneProduct
ENSBTAG00000012347 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:200931
SLC51B
GeneProduct
ENSBTAG00000003737 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:123264
SLCO1B1
GeneProduct
ENSBTAG00000022329 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10599
SULT2A1
GeneProduct
ENSBTAG00000039971 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6822
Silybin
Metabolite
31553 (PubChem-compound)
Tacrolimus
Metabolite
445643 (PubChem-compound)
Taurocholic acid
Metabolite
HMDB0000036 (HMDB)
Tetrahydrocortisone
Metabolite
HMDB0000903 (HMDB)
Trabectedin
Metabolite
108150 (PubChem-compound)
Troglitazone
Metabolite
5591 (PubChem-compound)
VDR
GeneProduct
ENSBTAG00000016414 (Ensembl)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7421
Annotated Interactions
No annotated interactions
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