Neural crest cell migration in cancer (Homo sapiens)
From WikiPathways
Description
Neural crest cells migrate and invade as part of normal development, but also as part of neuroblastoma metastasis in cancer. Many of the same growth factors, receptors and signaling pathways are involved. The participation of NTRK2 (TrkB), KIDINS220, and SORT1 (Sortilin) appear to be unique to the cancer signaling case, as well as the role for the intracellular domain fragment of NGFR (NGFR-ICD or p75ICD). Also see the closely related pathway, Neural Crest Cells during Development (https://www.wikipathways.org/index.php/Pathway:WP4565).
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Ontology Terms
Saving...Bibliography
- Wislet S, Vandervelden G, Rogister B; ''From Neural Crest Development to Cancer and Vice Versa: How p75NTRand (Pro)neurotrophins Could Act on Cell Migration and Invasion?''; Front Mol Neurosci, 2018 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| AKT1 | GeneProduct | 207 (Entrez Gene)  | AKT |
| AKT2 | GeneProduct | 208 (Entrez Gene) | AKT |
| AKT3 | GeneProduct | 10000 (Entrez Gene) | AKT |
| ARF1 | GeneProduct | 375 (Entrez Gene) | |
| BDNF | GeneProduct | 627 (Entrez Gene) | BDNF |
| CDH11 | GeneProduct | 1009 (Entrez Gene) | Cadherin |
| EPHB1 | GeneProduct | 2047 (Entrez Gene) | MMP |
| EPHB2 | GeneProduct | 2048 (Entrez Gene) | MMP |
| EPHB3 | GeneProduct | 2049 (Entrez Gene) | MMP |
| EPHB4 | GeneProduct | 2050 (Entrez Gene) | MMP |
| EPHB6 | GeneProduct | 2051 (Entrez Gene) | MMP |
| F2RL2 | GeneProduct | 2151 (Entrez Gene) | MMP |
| FOS | GeneProduct | 2353 (Entrez Gene) | AP-1 |
| JUN | GeneProduct | 3725 (Entrez Gene) | JUN/AP |
| KIDINS220 | GeneProduct | 57498 (Entrez Gene) | |
| MMP2 | GeneProduct | 4313 (Entrez Gene) | MMP2 |
| MMP8 | GeneProduct | 4317 (Entrez Gene) | MMP |
| MMP9 | GeneProduct | 4318 (Entrez Gene) | MMP |
| NGEF | GeneProduct | 25791 (Entrez Gene) | |
| NGFR-ICD | GeneProduct | 4804 (Entrez Gene) | |
| NGFR | GeneProduct | 4804 (Entrez Gene) | |
| NTRK2 | GeneProduct | 4915 (Entrez Gene) | |
| PAK1 | GeneProduct | 5058 (Entrez Gene) | |
| PAK2 | GeneProduct | 5062 (Entrez Gene) | |
| PAK3 | GeneProduct | 5063 (Entrez Gene) | |
| PAK4 | GeneProduct | 10298 (Entrez Gene) | |
| PAK5 | GeneProduct | 57144 (Entrez Gene) | |
| PAK6 | GeneProduct | 56924 (Entrez Gene) | |
| PIK3CA | GeneProduct | 5290 (Entrez Gene) | PI3K |
| PIK3CB | GeneProduct | 5291 (Entrez Gene) | PI3K |
| PIK3CD | GeneProduct | 5293 (Entrez Gene) | PI3K |
| PIK3CG | GeneProduct | 5294 (Entrez Gene) | PI3K |
| PIK3R3 | GeneProduct | 8503 (Entrez Gene) | PI3K |
| PIK3R4 | GeneProduct | 30849 (Entrez Gene) | PI3K |
| PIK3R5 | GeneProduct | 23533 (Entrez Gene) | PI3K |
| PIK3R6 | GeneProduct | 146850 (Entrez Gene) | PI3K |
| RAC1 | GeneProduct | 5879 (Entrez Gene) | |
| RHOA | GeneProduct | 387 (Entrez Gene) | RhoA |
| SORT1 | GeneProduct | 6272 (Entrez Gene) | |
| STAT3 | GeneProduct | 6774 (Entrez Gene) | STAT3 |
| TIAM1 | GeneProduct | 7074 (Entrez Gene) | Tiam |
| TRIO | GeneProduct | 7204 (Entrez Gene) | TRIO |
| TWIST1 | GeneProduct | 7291 (Entrez Gene) | Twist1, |
| proBDNF | GeneProduct | 627 (Entrez Gene) | BDNF |
Annotated Interactions
No annotated interactions
