Crystal toxin triggered necrosis pathway (Caenorhabditis elegans)
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Description
This pathway is modeled on a description provided in Zhang et al. under the title "A deficiency in the necrosis pathway confers tolerance to Cry6Aa". Cry6Aa binds to the calcium channel ITR-1 and increases intracellular Ca2+ levels. Ca2+ binds to and activates Calpain TRA-3 which promotes cysteine protease activity. Cysteine Protease activates VHA-12 that uses ATP to increase pH of the cytosol. The increase in H+ concentration signals to the ASP-1/ASP-3/ASP-4 complex which leads to activation of killer cathepsin protease and leads to cell necrosis.
Quality Tags
Ontology Terms
Saving...Bibliography
- Zhang F, Peng D, Cheng C, Zhou W, Ju S, Wan D, Yu Z, Shi J, Deng Y, Wang F, Ye X, Hu Z, Lin J, Ruan L, Sun M; ''Bacillus thuringiensis Crystal Protein Cry6Aa Triggers Caenorhabditis elegans Necrosis Pathway Mediated by Aspartic Protease (ASP-1).''; PLoS Pathog, 2016 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| ASP-1 | GeneProduct | WBGene00000214 (Ensembl)  | |
| ASP-3 | GeneProduct | WBGene00000216 (Ensembl) | |
| ASP-4 | GeneProduct | WBGene00000217 (Ensembl) | |
| ATP | Metabolite | HMDB0001532 (HMDB) | |
| Ca2+ | Metabolite | 271 (PubChem-compound) | |
| Calpain TRA-3 | GeneProduct | WBGene00006606 (Ensembl) | |
| Cry6Aa | GeneProduct | Q45757 (Uniprot-TrEMBL) | |
| Cysteine Protease | GeneProduct | WBGene00000543 (Ensembl) | |
| H+ | Metabolite | 1038 (PubChem-compound) | |
| ITR-1 Channel | GeneProduct | WBGene00002173 (Ensembl) | |
| Killer Cathepsin Protease | GeneProduct | WBGene00000783 (Ensembl) | |
| VHA-12 | GeneProduct | WBGene00006921 (Ensembl) |
Annotated Interactions
No annotated interactions
