Eukaryotic transcription initiation (Gallus gallus)

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1, 2TFIIB(recognize surface DNA geometry)TFIIE(mRNA, snRNPs)Steps 1) TBP binds TATA box3dsDNATFIIH35TATA Box bindingprotein5Steps 5) RNA elongation with CDT phosphorylation(large ribosomal RNAs)5TATATranscription Initiation Factors (TIFs)TFIIERNA polymerase ITATATATATFIIFRNA polymerase IIRNA pol IITFIIB3Gene Regulatory ProteinsSteps 3) DNA melting by association with TFIIH(small stable RNAs)TFIIA355TFIIA3cell growth33TFIIH3RNA polymerase III5Steps 2) Association of TIFs and RNA polymerase5Steps 4) Transcription elongation by NTPsTFIIDTFIIFTFIID35Primary RNA transcriptTFIIF55POLR1EPOLR1APOLR3KPOLR3BPOLR2KPOLR3HPOLR2BGTF2E2POLR2ETAF13TAF9RCJMB04_15p4TAF6GTF2BPOLR2AERCC3POLR2FGTF2E1POLR2GILKPOLR2JGTF2A2POLR2CPOLR3EPOLR2IGTF2F2POLR1DTBPMNAT1CCNHERCC2POLR1BGTF2H1GTF2H4TAF7GTF2H3GTF2H2CDK7POLR3DPOLR2HTAF12


Description

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: Wikipedia

Comments

GenMAPP notes 
Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP405(r29565) with a 80% conversion rate.

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Ontology Terms

 

Bibliography

  1. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed Europe PMC Scholia
  2. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
118407view14:14, 27 May 2021EweitzOntology Term : 'RNA polymerase III transcription initiation pathway' added !
118393view13:59, 27 May 2021EweitzOntology Term : 'PW:0001575' removed !
118392view13:59, 27 May 2021EweitzOntology Term : 'PW:0001274' removed !
118391view13:59, 27 May 2021EweitzOntology Term : 'PW:0001570' removed !
118390view13:58, 27 May 2021EweitzOntology Term : 'RNA polymerase III transcription initiation pathway' added !
118389view13:58, 27 May 2021EweitzOntology Term : 'RNA polymerase I transcription initiation pathway' added !
118388view13:58, 27 May 2021EweitzOntology Term : 'RNA polymerase II transcription initiation pathway' added !
118386view13:57, 27 May 2021EweitzOntology Term : 'PW:0000100' removed !
118385view13:57, 27 May 2021EweitzOntology Term : 'RNA polymerase I transcription initiation pathway' added !
118384view13:56, 27 May 2021EweitzOntology Term : 'RNA polymerase III transcription initiation pathway' added !
118381view13:55, 27 May 2021EweitzOntology Term : 'RNA polymerase II transcription initiation pathway' added !
117194view10:32, 18 May 2021EweitzModified title
68790view17:13, 8 July 2013MaintBotUpdated to 2013 gpml schema
67217view10:22, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
58767view22:15, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
47789view16:25, 6 April 2012Khanspersupdated xref
40921view22:51, 1 March 2011MaintBotRemoved redundant pathway information and comments
35527view13:57, 12 February 2010Thomasadded literature
35515view13:51, 12 February 2010ThomasModified description
33852view17:42, 9 December 2009MaintBotAutomatic update of empty xrefs
33500view15:13, 30 November 2009MaintBotRemoved group label
31547view21:51, 13 August 2009MaintBotFixed text labels
30399view21:09, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CCNHGeneProduct427328 (Entrez Gene)
CDK7GeneProduct771294 (Entrez Gene)
ERCC2GeneProduct
ERCC3GeneProduct424226 (Entrez Gene)
GTF2A2GeneProduct770910 (Entrez Gene)
GTF2BGeneProduct424518 (Entrez Gene)
GTF2E1GeneProduct418328 (Entrez Gene)
GTF2E2GeneProduct771227 (Entrez Gene)
GTF2F2GeneProduct418843 (Entrez Gene)
GTF2H1GeneProduct423081 (Entrez Gene)
GTF2H2GeneProduct
GTF2H3GeneProduct771837 (Entrez Gene)
GTF2H4GeneProduct
ILKGeneProduct374018 (Entrez Gene)
MNAT1GeneProduct423521 (Entrez Gene)
POLR1AGeneProduct422910 (Entrez Gene)
POLR1BGeneProduct416710 (Entrez Gene)
POLR1DGeneProduct428713 (Entrez Gene)
POLR1EGeneProductENSGALG00000005395 (Ensembl)
POLR2AGeneProduct
POLR2BGeneProduct422621 (Entrez Gene)
POLR2CGeneProduct415635 (Entrez Gene)
POLR2EGeneProduct420103 (Entrez Gene)
POLR2FGeneProduct395486 (Entrez Gene)
POLR2GGeneProduct
POLR2HGeneProduct424954 (Entrez Gene)
POLR2IGeneProduct426289 (Entrez Gene)
POLR2JGeneProduct
POLR2KGeneProduct768387 (Entrez Gene)
POLR3BGeneProduct418071 (Entrez Gene)
POLR3DGeneProduct
POLR3EGeneProduct416620 (Entrez Gene)
POLR3HGeneProduct417990 (Entrez Gene)
POLR3KGeneProduct768505 (Entrez Gene)
RCJMB04_15p4GeneProduct423872 (Entrez Gene)
TAF12GeneProduct419585 (Entrez Gene)
TAF13GeneProduct418365 (Entrez Gene)
TAF6GeneProduct776310 (Entrez Gene)
TAF7GeneProduct422192 (Entrez Gene)
TAF9GeneProduct422152 (Entrez Gene)
TBPGeneProduct395995 (Entrez Gene)

Annotated Interactions

No annotated interactions
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