Prostaglandin and leukotriene metabolism in senescence (Homo sapiens)

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10101013101010p38 MAPKp35PGE2GsCa 2+Cytosolic phospholipase A2SenescenceEP2IL-615d-PGJ2PTGEScAMPInflammationPGD2Adrenic acidPGG2PTGDSPGH2Cytosolic phospholipase A2Adenylyl CyclaseIGFBP5COX-1TXA2dihomo-15d-PGJ2PLCMembrane phospholipidsArachidonic acidPGI2StressCOX-2PGD SynthasePGE SynthasePGI SynthaseTxA SynthasePGF SynthasePGF2alphaRASEP1EP3 (extracellular)EP3 (intracellular)EP4G0GiGqAdenylyl CyclasecAMPp35P3, 123, 128, 115, 9, 141, 109, 149, 147, 9, 133, 127, 1377, 13145, 139, 146109, 145, 159, 143, 128, 117, 135, 154, 118, 118, 1127, 13SASPALOX5APCa2+ALOX5LTC4SLTA4HALOX15Bp21LTB45-HPETELTD4ROSp53Retinoblastoma proteinALOX15LTA4LTE4LTC4SIRT1ALOX12CysLT1Rp53PRetinoblastoma proteinPSenescence


Description

Prostaglandin Metabolism in Senescence

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Lin Y, Xu Z; ''Fibroblast Senescence in Idiopathic Pulmonary Fibrosis.''; Front Cell Dev Biol, 2020 PubMed Europe PMC Scholia
  2. Wei J, Chen S, Guo W, Feng B, Yang S, Huang C, Chu J; ''Leukotriene D4 induces cellular senescence in osteoblasts.''; Int Immunopharmacol, 2018 PubMed Europe PMC Scholia
  3. Suryadevara V, Ramchandran R, Kamp DW, Natarajan V; ''Lipid Mediators Regulate Pulmonary Fibrosis: Potential Mechanisms and Signaling Pathways.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
  4. Catalano A, Rodilossi S, Caprari P, Coppola V, Procopio A; ''5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation.''; EMBO J, 2005 PubMed Europe PMC Scholia
  5. Wiley CD, Sharma R, Davis SS, Lopez-Dominguez JA, Mitchell KP, Wiley S, Alimirah F, Kim DE, Payne T, Rosko A, Aimontche E, Deshpande SM, Neri F, Kuehnemann C, Demaria M, Ramanathan A, Campisi J; ''Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.''; Cell Metab, 2021 PubMed Europe PMC Scholia
  6. Cormenier J, Martin N, Deslé J, Salazar-Cardozo C, Pourtier A, Abbadie C, Pluquet O; ''The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E2intracrine pathway.''; Mech Ageing Dev, 2018 PubMed Europe PMC Scholia
  7. Yang HH, Kim C, Jung B, Kim KS, Kim JR; ''Involvement of IGF binding protein 5 in prostaglandin E(2)-induced cellular senescence in human fibroblasts.''; Biogerontology, 2011 PubMed Europe PMC Scholia
  8. Häfner AK, Kahnt AS, Steinhilber D; ''Beyond leukotriene formation-The noncanonical functions of 5-lipoxygenase.''; Prostaglandins Other Lipid Mediat, 2019 PubMed Europe PMC Scholia
  9. Wiley CD, Brumwell AN, Davis SS, Jackson JR, Valdovinos A, Calhoun C, Alimirah F, Castellanos CA, Ruan R, Wei Y, Chapman HA, Ramanathan A, Campisi J, Jourdan Le Saux C; ''Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis.''; JCI Insight, 2019 PubMed Europe PMC Scholia
  10. Menna C, Olivieri F, Catalano A, Procopio A; ''Lipoxygenase inhibitors for cancer prevention: promises and risks.''; Curr Pharm Des, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
119484view08:41, 2 July 2021EgonwUpdated data source so that link out work.
119438view07:46, 29 June 2021DKalbeDescription prostaglandins
119423view17:57, 28 June 2021JDoreenReferences
119416view12:11, 28 June 2021JDoreenAdded references and state
119412view09:59, 28 June 2021DKalbeChanging an arrow
119411view09:31, 28 June 2021JDoreenCorrections
119410view06:58, 28 June 2021DKalbeFixing interactions and description
119390view10:02, 27 June 2021JDoreenAnnotations
119380view12:00, 25 June 2021DKalbeDescription leukotrienes
119376view11:33, 25 June 2021TadeIdowuAnnotation
119374view10:46, 25 June 2021EweitzOntology Term : 'aging pathway' added !
119373view10:41, 25 June 2021EweitzOntology Term : 'leukotriene metabolic pathway' added !
119372view10:40, 25 June 2021EweitzOntology Term : 'prostaglandin metabolic pathway' added !
119369view10:34, 25 June 2021EweitzModified title
119354view19:28, 24 June 2021JDoreenAnnotations.
119353view14:14, 24 June 2021Aysegul CelikModified title
119343view10:05, 24 June 2021DKalbeData node
119342view09:56, 24 June 2021DKalbeData nodes
119341view09:49, 24 June 2021DKalbeData nodes
119340view09:33, 24 June 2021DKalbeData nodes
119339view09:17, 24 June 2021DKalbeReferences
119331view15:48, 23 June 2021JDoreenAnnotations
119326view15:14, 23 June 2021JDoreenArrows and boxes.
119322view14:43, 23 June 2021JDoreenModified description
119321view14:28, 23 June 2021JDoreenp53 and ROS.
119320view13:47, 23 June 2021JDoreenChanged anchoring of some arrows and some boxes. Added shape to pathways.
119302view13:03, 23 June 2021Frucsek13Modified title
119299view11:45, 23 June 2021TadeIdowuP38 MAPK
119298view11:39, 23 June 2021TadeIdowuRAS Protein
119297view11:30, 23 June 2021TadeIdowuAnnotation & Arrows
119295view11:24, 23 June 2021TadeIdowuAnnotation
119228view18:42, 22 June 2021DKalbemodifying references
119225view18:35, 22 June 2021DKalbeAddition of leukotriene metabolism pathway
119220view16:30, 22 June 2021TadeIdowuAddition of Phsophorylation and Annotation
119214view14:41, 22 June 2021Mario5181Modified title
119213view14:41, 22 June 2021Mario5181Modified title
119212view14:20, 22 June 2021JDoreenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
15d-PGJ2
5-HPETEMetaboliteHMDB11135 (HMDB)
ALOX12GeneProductENSG00000108839 (Ensembl)
ALOX15BGeneProductENSG00000179593 (Ensembl)
ALOX15GeneProductENSG00000161905 (Ensembl)
ALOX5APGeneProductENSG00000132965 (Ensembl)
ALOX5GeneProductENSG00000012779 (Ensembl)
Adenylyl Cyclase
Adrenic acidMetaboliteCHEBI:53487 (ChEBI)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
COX-1
COX-2
Ca 2+
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CysLT1RProteinQ9Y271 (Uniprot-TrEMBL)
Cytosolic phospholipase A2ProteinP47712 (Uniprot-TrEMBL)
EP1
EP2
EP3 (extracellular)
EP3 (intracellular)
EP4
G0Protein
GiProtein
GqProtein
GsProtein
IGFBP5GeneProductENSG00000115461 (Ensembl)
IL-6
Inflammation
LTA4MetaboliteCHEBI:15651 (ChEBI)
LTA4HGeneProductENSG00000111144 (Ensembl)
LTB4MetaboliteCHEBI:15647 (ChEBI)
LTC4MetaboliteCHEBI:16978 (ChEBI)
LTC4SGeneProductENSG00000213316 (Ensembl)
LTD4MetaboliteCHEBI:28666 (ChEBI)
LTE4MetaboliteCHEBI:15650 (ChEBI)
Membrane phospholipidsMetaboliteCHEBI:16247 (ChEBI)
PGD Synthase
PGD2MetaboliteCHEBI:15555 (ChEBI)
PGE Synthase
PGE2MetaboliteCHEBI:15551 (ChEBI)
PGF Synthase
PGF2alphaMetaboliteCHEBI:15553 (ChEBI)
PGG2MetaboliteCHEBI:27647 (ChEBI)
PGH2MetaboliteCHEBI:15554 (ChEBI)
PGI Synthase
PGI2MetaboliteCHEBI:15552 (ChEBI)
PLC
PTGDSGeneProductENSG00000107317 (Ensembl)
PTGESGeneProductENSG00000148344 (Ensembl)
RASPathway
ROSPathway
Retinoblastoma proteinGeneProduct
SIRT1GeneProductENSG00000096717 (Ensembl)
SenescencePathway
StressGeneProduct
TXA2MetaboliteCHEBI:15627 (ChEBI)
TxA Synthase
cAMP
dihomo-15d-PGJ2Metabolite
p21ProteinA0A024RCX5 (Uniprot-TrEMBL)
p35
p38 MAPKPathway
p53MetaboliteCHEBI:77731 (ChEBI)

Annotated Interactions

No annotated interactions

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