Serotonin and anxiety-related events (Homo sapiens)

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12Cell in prefrontal cortexAnxiety related eventsHTR2ASerotoninARCKetanserinHTR2CHTR1A2FOSPLEKPPP3CAPRKCBPLCD4GRIN2DNLGN13CRHR11CRH


Description

Stress and anxiety disorders are risk factors for depression and these behaviours are modulated by corticotropin releasing factor (CRFR1) and serotonin (5-HT2R) receptors. (Source: Berg et al "5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms"). Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "Serotonin and anxiety-related events", WP2140 revision 89987, with a 100.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Magalhaes AC, Holmes KD, Dale LB, Comps-Agrar L, Lee D, Yadav PN, Drysdale L, Poulter MO, Roth BL, Pin JP, Anisman H, Ferguson SS; ''CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling.''; Nat Neurosci, 2010 PubMed Europe PMC Scholia
  2. Benekareddy M, Goodfellow NM, Lambe EK, Vaidya VA; ''Enhanced function of prefrontal serotonin 5-HT(2) receptors in a rat model of psychiatric vulnerability.''; J Neurosci, 2010 PubMed Europe PMC Scholia
  3. Berg KA, Clarke WP, Chen Y, Ebersole BJ, McKay RD, Maayani S; ''5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms.''; Mol Pharmacol, 1994 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129057view01:50, 10 March 2024EweitzOntology Term : 'PW:0000013' removed !
120596view21:23, 17 December 2021EweitzRefine graphics, text
106484view19:49, 3 September 2019KhanspersModified description
106140view12:03, 16 August 2019MaintBotHMDB identifier normalization
105812view22:55, 15 August 2019KhanspersModified description
102003view15:30, 23 November 2018EgonwRemoved whitespace in PubMed identifiers.
90836view19:16, 14 December 2016KhanspersOntology Term : 'signaling pathway' added !
90835view19:15, 14 December 2016KhanspersOntology Term : 'cerebral cortex neuron' added !
90834view19:14, 14 December 2016KhanspersOntology Term : 'disease pathway' added !
90833view19:14, 14 December 2016KhanspersOntology Term : 'anxiety disorder' added !
90832view19:14, 14 December 2016KhanspersModified description
90831view19:13, 14 December 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARCGeneProductENSG00000198576 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022602
CRHProteinENSG00000147571 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8CIT0
CRHR1GeneProductENSG00000120088 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018634
FOSGeneProductENSG00000170345 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021250
GRIN2DGeneProductENSG00000105464 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002771
HTR1AGeneProductENSG00000178394 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021721
HTR2AGeneProductENSG00000102468 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034997
HTR2CGeneProductENSG00000147246 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000041380
KetanserinMetaboliteCHEBI:6123 (ChEBI)
NLGN1GeneProductENSG00000169760 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000063887
PLCD4GeneProductENSG00000115556 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026173
PLEKGeneProductENSG00000115956 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020120
PPP3CAGeneProductENSG00000138814 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:107164
PRKCBGeneProductENSG00000166501 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000052889
SerotoninMetaboliteHMDB0000259 (HMDB)

Annotated Interactions

No annotated interactions
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