HIPK2 in kidney fibrosis (Homo sapiens)
From WikiPathways
Description
This pathway shows the activation of multiple signaling pathways involved in kidney fibrosis, starting from an insult like HIV infection or oxidative stress, through the suppression of SIAH1 and increased expression of HIPK2.
This pathway was adapted from Figure 6i of Jin et. al.
Quality Tags
 | Review changes for Approved |
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Ontology Terms
Saving...Pathway Ontology : hyperprolinemia type II disease pathway disease pathway lysine degradation pathway hypophosphatasia disease pathway vitamin B6 metabolic pathway proline metabolic pathway
Disease : hypophosphatasia epilepsy infantile hypophosphatasia hyperprolinemia type 2 early-onset vitamin B6-dependent epilepsy childhood hypophosphatasia pyridoxamine 5'-phosphate oxidase deficiency pyridoxine-dependent epilepsy
Cell Type : neural cell
Bibliography
- Jin Y, Ratnam K, Chuang PY, Fan Y, Zhong Y, Dai Y, Mazloom AR, Chen EY, D'Agati V, Xiong H, Ross MJ, Chen N, Ma'ayan A, He JC; ''A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.''; Nat Med, 2012 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name  | Type | Database reference | Comment |
|---|---|---|---|
| HIPK2 | GeneProduct | 28996 (Entrez Gene)  | |
| NF-kB signaling | Pathway | WP4562 (WikiPathways) | |
| Notch signaling | Pathway | WP268 (WikiPathways) | |
| SIAH1 | GeneProduct | 6477 (Entrez Gene) | |
| TGF-B signaling | Pathway | WP3874 (WikiPathways) | |
| Wnt / B-catenin signaling | Pathway | WP4150 (WikiPathways) | |
| p53 pathway | Pathway | WP707 (WikiPathways) |
Annotated Interactions
No annotated interactions
