Glucose metabolism in triple-negative breast cancer cells (Homo sapiens)

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1GlycolysisLDHAphosphoenolpyruvateGlucoseNADPHglucose-6-phosphateHKPDHLactateGLUT1Fructose-6-phosphatePyruvateTCA cyclePentose phosphate pathwayfructose-1,6-bisphosphateAcetyl CoAPFKPPDK1MCT1Respiratory chainGlucoseLactatepyruvatePKM2


Description

Glucose metabolism in triple-negative breast cancer cells. The glycolytic pathway is significantly upregulated in triple-negative breast tumors. The genes coding the key glycolytic enzymes are overexpressed in triple-negative breast tumors. TCA, tricarboxylic acid cycle; G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; F1,6P, fructose-1,6-bisphosphate; PEP, phosphoenolpyruvate; OAA, oxaloacetate; α-KG, α-ketoglutarate; GLUT, glucose transporter; HK, hexokinase; PFK, phosphofructokinase; PKM2, pyruvate kinase isozyme type 2; LDHA, lactate dehydrogenase A; MCT1, monocarboxylate transporter 1; PDK1, pyruvate dehydrogenase kinase 1; PDH, pyruvate dehydrogenase.

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Ontology Terms

 

Bibliography

  1. Avanzato D, Pupo E, Ducano N, Isella C, Bertalot G, Luise C, Pece S, Bruna A, Rueda OM, Caldas C, Di Fiore PP, Sapino A, Lanzetti L; ''High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis.''; Cancer Res, 2018 PubMed Europe PMC Scholia
  2. Sun X, Wang M, Yu X, Guo J, Sun T, Li X, Yao L, Dong H, Xu Y; ''Metabolic Reprogramming in Triple-Negative Breast Cancer.''; Front Oncol, 2020 PubMed Europe PMC Scholia
  3. Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey B, Hay N; ''Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer.''; Cancer Cell, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134565view22:16, 22 July 2024EweitzOntology Term : 'glucose metabolic pathway' added !
134564view22:16, 22 July 2024EweitzOntology Term : 'breast cancer' added !
129315view13:53, 26 March 2024MkutmonOntology Term : 'cancer pathway' added !
129314view13:53, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
122576view13:33, 17 April 2022EgonwMade a pathway clickable
122405view08:57, 30 March 2022Andraconnected unconnected line
122404view08:53, 30 March 2022Andraadded identifiers to data nodes
122316view17:18, 17 March 2022Andraadded references
122315view17:05, 17 March 2022AlexanderPicoremoving fill color for data vis use cases
122314view17:04, 17 March 2022AndraOntology Term : 'pentose phosphate pathway' added !
122313view17:03, 17 March 2022AndraOntology Term : 'glycolysis pathway' added !
122312view17:03, 17 March 2022AndraOntology Term : 'citric acid cycle pathway' added !
122311view17:00, 17 March 2022Andrabeautify
122310view16:54, 17 March 2022AndraAdded catalytic relationships
122309view16:37, 17 March 2022Andraadd upregulated state to Wikipathways
122293view15:44, 17 March 2022EgonwAdded more metabolite identifiers
122292view15:33, 17 March 2022EgonwAdded an identifier and made two pathways clickable
122291view14:54, 17 March 2022Andraadded identifiers with bridgedb plugin
122290view14:32, 17 March 2022Andraadded some identifiers
122289view14:21, 17 March 2022AndraAdded geneproducts
122287view14:15, 17 March 2022AndraAdded original paper where this pathway is described and drawn
122286view14:14, 17 March 2022Andraadded additional metabolites
122279view13:38, 17 March 2022Andraedge connect
122278view13:36, 17 March 2022Andraalign metabolites
122254view13:04, 16 March 2022AndraOntology Term : 'triple-receptor negative breast cancer' added !
122253view13:01, 16 March 2022AndraNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Acetyl CoAMetaboliteCHEBI:15351 (ChEBI)
Fructose-6-phosphateMetaboliteCHEBI:15946 (ChEBI)
GLUT1GeneProduct6513 (Entrez Gene)
GlucoseMetaboliteQ37525 (Wikidata)
GlycolysisPathway
HKGeneProduct3098 (Entrez Gene)
LDHAGeneProductENSG00000134333 (Ensembl)
LactateMetaboliteCHEBI:16651 (ChEBI)
MCT1GeneProduct6566 (Entrez Gene)
NADPHMetaboliteCHEBI:16474 (ChEBI)
PDHGeneProduct54704 (Entrez Gene)
PDK1GeneProductENSG00000152256 (Ensembl)
PFKPGeneProduct5214 (Entrez Gene)
PKM2GeneProduct
Pentose phosphate pathwayPathwayWP134 (WikiPathways)
PyruvateMetaboliteCHEBI:15361 (ChEBI)
Respiratory chainPathway
TCA cyclePathwayWP78 (WikiPathways)
fructose-1,6-bisphosphateMetaboliteCHEBI:78682 (ChEBI)
glucose-6-phosphateMetaboliteQ32778969 (Wikidata)
phosphoenolpyruvateMetaboliteCHEBI:18021 (ChEBI)
pyruvateMetaboliteCHEBI:15361 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5211"
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