Frustrated phagocytosis leading to malignant pleural mesothelioma (Homo sapiens)

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Overview of proinflammatory and profibrotic mediatorsCell cycle checkpoints Increased secretion of proinflammatory mediatorsIncreased reactive oxygen speciesFrustrated phagocytosisDNA repair pathwaysDNA damage response Oxidative damage response Increased recruitment of inflammatory cells Genomic instabilityMesothelial cell proliferationMesotheliomaIncreased DNA damage and mutationCell CycleMalignant Pleural Mesothelioma


Description

Adverse Outcome Pathway for malignant pleural mesothelioma, known to be initiated by asbestos. Hypothetical sequence of events, which are planned for development in the AOP-Wiki, hence the lacking Key Event IDs.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Akio Kuroda; ''Recent progress and perspectives on the mechanisms underlying Asbestos toxicity''; , 2021 PubMed Europe PMC Scholia
  2. Gupta SS, Singh KP, Gupta S, Dusinska M, Rahman Q; ''Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?''; Nanomaterials (Basel), 2022 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134123view07:53, 25 June 2024PhilipErnstchanged one key event to match Hallmarks of cancer
134110view11:16, 20 June 2024PhilipErnstchanged one linked pathway
134090view12:04, 13 June 2024Marvin M2connected line and removed AO pathway
134089view11:07, 13 June 2024PhilipErnstUpdated with hallmarks of cancer
129340view09:18, 27 March 2024MkutmonOntology Term : 'disease pathway' added !
124069view12:18, 15 September 2022Marvin M2Modified title
124068view12:18, 15 September 2022Marvin M2Modified description
124067view12:15, 15 September 2022Marvin M2Added references
123058view11:45, 22 June 2022Alexandraboschswitched Key Event
122802view12:21, 18 May 2022Alexandraboschfixed connection between Increased DNA damage and Genomic instability
122666view10:16, 28 April 2022Alexandraboschaddition of NRF2 pathway node
122653view10:14, 26 April 2022Alexandraboschadded KE IDs
122652view10:07, 26 April 2022Alexandraboschfixed layout
122651view10:04, 26 April 2022Alexandraboschaddition of pathway nodes
122650view09:32, 26 April 2022Alexandraboschadapted according to AOP-Wiki
122638view13:10, 24 April 2022Alexandraboschadded KE ID for oxidative stress, DNA double strand breaks, increased mutation, chromosome breaks and rearrangement & Mesothelioma
122637view12:57, 24 April 2022Alexandraboschadded KE ID for mesothelial cell proliferation
122589view15:04, 19 April 2022Marvin M2added KE ID for genomic instability
118961view10:48, 5 June 2021EweitzOntology Term : 'mesothelial cell' added !
116743view15:48, 11 May 2021Marvin M2Ontology Term : 'malignant pleural mesothelioma' added !
116742view15:48, 11 May 2021Marvin M2Modified description
116741view15:40, 11 May 2021Marvin M2Added KE pathway
116328view15:05, 30 April 2021Marvin M2New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Cell CyclePathwayWP179 (WikiPathways)
Cell cycle checkpoints PathwayWP1775 (WikiPathways)
DNA damage response PathwayWP707 (WikiPathways)
DNA repair pathwaysPathwayWP4946 (WikiPathways)
Frustrated phagocytosis
Genomic instabilityKey Event1896 (AOP-Wiki KE)
Increased DNA damage and mutation
Increased reactive oxygen species
Increased recruitment of inflammatory cells
Increased secretion of proinflammatory mediators
Malignant Pleural MesotheliomaPathwayWP5087 (WikiPathways)
Mesothelial cell proliferationKey Event870 (AOP-Wiki KE)
MesotheliomaKey Event1090 (AOP-Wiki KE)
Overview of proinflammatory and profibrotic mediatorsPathwayWP5095 (WikiPathways)
Oxidative damage response PathwayWP3941 (WikiPathways)

Annotated Interactions

No annotated interactions

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