Comprehensive IL-17A signaling (Mus musculus)

From WikiPathways

Revision as of 06:32, 28 June 2022 by Rex D A B (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
IL-17A mediated pulmonary SMAD- dependent and non-dependent mechanism during acute lung injury in vivoInflammation, apoptosis, and migration TGF-β signalingHuman bronchial epithelial (HBE) cellsDissociationChemokine ligands Alveolar basal epithelial A549 cells InterleukinsγδT and Th17 cells Bleomycin-induced pulmonary fibrotic mice modelPulmonary inflammation and fibrosis Minichromosome maintenance (MCM) proteins invovled in DNA replicationCcl3EgfrIL-10Pole3Cdc42PlaurPuraCSF3PcnaCdc42Ccl5Cxcl1Nucks1Serpine1CXCL1Cxcl5Npm1Cxcl12ACTA2Rac1Ccl4CacybpLIFActa1IL-6Upf1COL3A1AtrxHSPG2Zmpste24MUC5ACFn1PlauCOL5A2IL-11CrebbpTNFVCANCXCL8Srpk2Samhd1Casp3Parp1Rbbp4CCL2 Orc1Dhx9TGFB1Orc2NaspCXCL2Sqstm1Acta2Igf1Acta2Map1lc3bBaffFbn1Bcl2IL1BHspa1bSnai1Mki67Mcm7Adh1Hmgb1Smad6Col1a1PdgfbHbb-bh1Sod2STAT1Y701RelaPlch1mTORS2448CXCL5Smad2S465S467P53IL17RAPrkacb MAPK1PPRKAA1MAPK3Anxa6PPlauIl1bPtgs2CXCL6Mmp3PI3KCAY199Becn1Y458IL17AAKT1Stat1S473Ccn2IL17RARac1MAPK14MtorMylkGng12Uggt1Stat3Y705Il6Mcm5RELAS536Casp3PdgfaRab10Serpine1RELAS536Cpne1NFKB1Map1lc3aNFKBIAC3Arpc2Smad7 CXCL1RELAEGFRNFKB1Y1068BECN1 NFKBIAPik3c3CFBActa2Cxcl1Hbb-b2Col1a1BCL2Psmc6PlaurRelaMcm4Mcm6GSK3BS9Particulate matter (PM2.5)CXCL3Bleomycin induced IL-17A activationMcm2TGFB1Ppp1r14bActa2BlmhSnai2IL8Experimental silica treatment in miceP53RhoaAutophagyPak3GRK5Il1bIL6C7 Mmp14Arpc3Gap43Mcm3Smad3Degrease kinase activity GSK3BS425S423mTORInhibit autophagy in pulmonary fibrosis S2448IL17APIK3CAPActa2Inflammatory neutrophils in the bronchoalveolar space Rras2Arpc5Atox1Hyou1 FibrosisPon3IL-17A stimulationNgpIL-17ACxcl12 IL17RAMmp9Cxcl2Hbb-b1TNFB1Smad2S467S465Smad3S423S425JAK2Y1007Y1008JAK1Y1035Y1034STAT3Y705Acute lung injurySTAT1/3 mediated transcriptionalregulationMAPK1MAPK3PPmTORSTAT3IL-17AIL17RAJAK2JAK1Y1008Y1007Y1034Y1035P53PAkt1PMAPK14T183Y185Bleomycin induced IL-17A activationUnilateral Ureteral Obstruction (UUO) injuryIL-17A stimulationIL-17AIL17RANFKB1NFKBIAPChronic airway diseasesIL-17A stimulationReceptorProteinmRNALigand Inhibition Leads to through multiple reactionsLEGEND IL-17A stimulation Bleomycin induced IL-17A activationSmad3S423S425DissociationStat3Y705STAT1Y701STAT3Y705 Translocation Nucleus Cytoplasm Plasma membraneCYPMNU ExtracellularECGene/ProteinGene/Protein Upregulation DownregulationProteinP PhosphorylationDissociationNUCYNUCYNUCYNUCYActivationGram-negative bacterial pneumonia infection Airway epithelial cells Proliferation of asthmatic fibrocytes AsthmaIL-10ACTA2Extracellular matrix deposition and neovascularization Apoptosis and injury Bleomycin induced miceDegradation of BCL-2Human lung epithelial cellsBCL2S70Renal fibrosisSilicosis lung inflammation in miceSnai1Col1a1Snai2Tjp1Cdh1Epithelial-mesenchymal transition (EMT) markersHuman primary small airway epithelial cellsMouse alveolar epithelial (MLE-12) cells Jak2PJak1P


Description

Schematic representation of IL-17A signaling pathway

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Rex DAB, Dagamajalu S, Gouda MM, Suchitha GP, Chanderasekaran J, Raju R, Prasad TSK, Bhandary YP; ''A comprehensive network map of IL-17A signaling pathway.''; J Cell Commun Signal, 2022 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126495view21:40, 9 May 2023Khanspersadded missing groups, fixed interactions, converted interactions in legend to graphical lines
126212view09:41, 16 April 2023EgonwLicense is CCZero
124849view21:41, 14 December 2022EweitzModified title
124477view21:23, 30 October 2022AlexanderPicoModified description
124476view21:22, 30 October 2022AlexanderPicomore xrefs
124475view21:15, 30 October 2022AlexanderPicoremoved off-map nodes; added ref
124474view21:13, 30 October 2022AlexanderPicocompleted xrefs; fixed legend to use labels
123976view10:33, 9 September 2022EweitzModified title
123802view18:04, 15 August 2022KhanspersOntology Term : 'interleukin-17 family mediated signaling pathway' added !
123801view18:04, 15 August 2022KhanspersOntology Term : 'signaling pathway' added !
123125view04:40, 5 July 2022EgonwWorked on the data sources
123092view08:08, 29 June 2022Rex D A BAnnotations
123091view07:35, 29 June 2022Rex D A BAlignment
123090view06:32, 28 June 2022Rex D A BNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTA2GeneProduct59 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
Acta1GeneProduct11459 (Entrez Gene)
Acta2GeneProduct11475 (Entrez Gene)
Acta2GeneProductActa2
Acta2ProteinP62737 (Uniprot-SwissProt)
Adh1GeneProductAdh1
Akt1ProteinP31750 (Uniprot-SwissProt)
Anxa6GeneProductAnxa6
Arpc2GeneProductArpc2
Arpc3GeneProductArpc3
Arpc5GeneProductArpc5
Atox1GeneProductAtox1
AtrxProteinQ61687 (Uniprot-SwissProt)
BCL2ProteinP10415.2 (Uniprot-SwissProt)
BECN1 ProteinQ14457.2 (Uniprot-SwissProt)
BaffGeneProduct24099 (Entrez Gene)
Bcl2ProteinP10417 (Uniprot-SwissProt)
Becn1ProteinO88597 (Uniprot-SwissProt)
BlmhGeneProductBlmh
C3GeneProduct12266 (Entrez Gene)
C7 GeneProductC7
CCL2 ProteinP13500 (Uniprot-SwissProt)
CFBGeneProduct629 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
COL5A2GeneProduct1290 (Entrez Gene)
CSF3ProteinP09919 (Uniprot-SwissProt)
CXCL1GeneProduct2919 (Entrez Gene)
CXCL1ProteinP09341 (Uniprot-SwissProt)
CXCL2GeneProduct2920 (Entrez Gene)
CXCL3GeneProduct2921 (Entrez Gene)
CXCL5GeneProduct20311 (Entrez Gene)
CXCL6GeneProductCXCL6
CXCL8ProteinP10145 (Uniprot-TrEMBL)
CacybpProteinQ9CXW3 (Uniprot-SwissProt)
Casp3GeneProduct12367 (Entrez Gene)
Casp3ProteinP05122 (Uniprot-SwissProt)
Ccl3GeneProduct20302 (Entrez Gene)
Ccl4GeneProduct20303 (Entrez Gene)
Ccl5GeneProduct20304 (Entrez Gene)
Ccn2GeneProduct14219 (Entrez Gene)
Cdc42GeneProductCdc42
Cdc42ProteinP60766 (Uniprot-SwissProt)
Cdh1ProteinP09803 (Uniprot-SwissProt)
Col1a1GeneProduct12842 (Entrez Gene)
Col1a1ProteinP02452 (Uniprot-SwissProt)
Cpne1GeneProductCpne1
CrebbpGeneProductP45481 (Uniprot-SwissProt)
Cxcl1GeneProduct14825 (Entrez Gene)
Cxcl12 ProteinP40224 (Uniprot-SwissProt)
Cxcl12GeneProduct20315 (Entrez Gene)
Cxcl2GeneProduct20310 (Entrez Gene)
Cxcl5GeneProduct20311 (Entrez Gene)
Dhx9ProteinO70133 (Uniprot-SwissProt)
EGFRProteinQ01279 (Uniprot-SwissProt)
EgfrProteinQ01279 (Uniprot-SwissProt)
Fbn1GeneProduct14118 (Entrez Gene)
Fn1GeneProduct14268 (Entrez Gene)
GRK5GeneProduct2869 (Entrez Gene)
GSK3BProteinP49841 (Uniprot-SwissProt)
Gap43GeneProductGap43
Gng12GeneProductGng12
HSPG2GeneProduct3339 (Entrez Gene)
Hbb-b1GeneProductHbb-b1
Hbb-b2GeneProductHbb-b2
Hbb-bh1GeneProductHbb-bh1
Hmgb1GeneProductHmgb1
Hspa1bGeneProductHspa1b
Hyou1 GeneProductHyou1
IL-10ProteinP22301 (Uniprot-SwissProt)
IL-11ProteinP20809 (Uniprot-SwissProt)
IL-17AGeneProduct3605 (Entrez Gene)
IL-6ProteinP05231 (Uniprot-SwissProt)
IL17AGeneProduct3605 (Entrez Gene)
IL17RAGeneProduct23765 (Entrez Gene)
IL1BGeneProductP01584.2 (Uniprot-SwissProt)
IL6GeneProduct3569 (Entrez Gene)
IL8GeneProduct20309 (Entrez Gene)
Igf1GeneProduct16000 (Entrez Gene)
Il1bGeneProduct16176 (Entrez Gene)
Il1bProteinP10749 (Uniprot-SwissProt)
Il6GeneProduct16193 (Entrez Gene)
JAK1ProteinP23458 (Uniprot-SwissProt)
JAK2ProteinO60674 (Uniprot-SwissProt)
Jak1ProteinP52332 (Uniprot-SwissProt)
Jak2ProteinQ62120 (Uniprot-SwissProt)
LIFProteinP15018 (Uniprot-SwissProt)
MAPK14GeneProduct1432 (Entrez Gene) p38
MAPK14ProteinQ16539 (Uniprot-SwissProt) p38
MAPK1GeneProduct5594 (Entrez Gene) p38
MAPK1ProteinP28482 (Uniprot-SwissProt) p38
MAPK3GeneProduct5595 (Entrez Gene)
MAPK3ProteinP27361 (Uniprot-SwissProt)
MUC5ACGeneProduct4586 (Entrez Gene)
Map1lc3aProteinQ91VR7 (Uniprot-SwissProt)
Map1lc3bProteinQ9CQV6 (Uniprot-SwissProt)
Mcm2ProteinP97310 (Uniprot-SwissProt)
Mcm3ProteinP25206 (Uniprot-SwissProt)
Mcm4Protein17217 (Entrez Gene)
Mcm5GeneProduct17218 (Uniprot-SwissProt)
Mcm6ProteinP97311 (Uniprot-SwissProt)
Mcm7GeneProductQ61881 (Uniprot-SwissProt)
Mki67GeneProduct17345 (Entrez Gene)
Mmp14GeneProduct17387 (Entrez Gene)
Mmp3GeneProduct17392 (Entrez Gene)
Mmp9GeneProduct17395 (Entrez Gene)
MtorGeneProduct56717 (Entrez Gene)
MylkGeneProductMylk
NFKB1GeneProduct4790 (Entrez Gene)
NFKB1ProteinP19838 (Uniprot-SwissProt)
NFKBIAGeneProduct4792 (Entrez Gene)
NaspProteinQ99MD9 (Uniprot-SwissProt)
NgpGeneProductNgp
Npm1ProteinQ61937 (Uniprot-SwissProt)
Nucks1ProteinQ80XU3 (Uniprot-SwissProt)
Orc1ProteinQ9Z1N2 (Uniprot-SwissProt)
Orc2ProteinQ60862 (Uniprot-SwissProt)
P53GeneProduct22059 (Entrez Gene)
P53ProteinP04637 (Entrez Gene)
P53ProteinP04637 (Uniprot-SwissProt)
PI3KCAProtein5290 (Entrez Gene)
PIK3CAGeneProductPIK3CA
PRKAA1ProteinQ13131 (Uniprot-SwissProt)
Pak3GeneProductPak3
Parp1ProteinP11103 (Uniprot-SwissProt)
PcnaProteinP17918 (Entrez Gene)
PdgfaGeneProduct18590 (Entrez Gene)
PdgfbGeneProduct18591 (Entrez Gene)
Pik3c3ProteinQ6PF93 (Uniprot-SwissProt)
PlauGeneProduct18792 (Entrez Gene)
PlauProteinP06869 (Uniprot-SwissProt)
PlaurGeneProduct18793 (Entrez Gene)
PlaurProteinP35456 (Uniprot-SwissProt)
Plch1GeneProductPlch1
Pole3ProteinQ9JKP7 (Uniprot-SwissProt)
Pon3GeneProductPon3
Ppp1r14bGeneProductPpp1r14b
Prkacb GeneProductPrkacb
ProteinGeneProductTNFB1 (Ensembl)
Psmc6GeneProductPsmc6
Ptgs2GeneProduct19225 (Entrez Gene)
PuraProteinP42669 (Uniprot-SwissProt)
RELAProteinQ04206 (Entrez Gene)
RELAProteinQ04206 (Uniprot-SwissProt)
Rab10GeneProductRab10
Rac1ProteinP63001 (Uniprot-SwissProt)
Rac1GeneProductRac1
Rbbp4ProteinQ60972 (Uniprot-SwissProt)
RelaGeneProductRela
RhoaGeneProductRhoa
Rras2GeneProductRras2
STAT1ProteinP42224 (Uniprot-SwissProt)
STAT3GeneProduct6774 (Entrez Gene)
STAT3GeneProductP40763 (Uniprot-SwissProt)
Samhd1ProteinQ60710 (Uniprot-SwissProt)
Serpine1GeneProduct66870 (Entrez Gene)
Serpine1ProteinP05121 (Uniprot-SwissProt)
Smad2Protein17126 (Uniprot-SwissProt)
Smad2ProteinQ62432 (Uniprot-SwissProt)
Smad3Protein17127 (Uniprot-SwissProt)
Smad3ProteinQ8BUN5 (Uniprot-SwissProt)
Smad6ProteinO35182 (Uniprot-SwissProt)
Smad7 ProteinO35253 (Uniprot-SwissProt)
Snai1ProteinQ02085 (Uniprot-SwissProt)
Snai2ProteinP97469 (Uniprot-SwissProt)
Sod2GeneProductSod2
Sqstm1ProteinQ64337 (Uniprot-SwissProt)
Srpk2ProteinO54781 (Uniprot-SwissProt)
Stat1GeneProductStat1
Stat3ProteinP42227 (Uniprot-SwissProt)
TGFB1ProteinP04202 (Uniprot-SwissProt)
TGFB1GeneProductTGFB1
TNFB1GeneProductTNFB1 (Ensembl)
TNFProteinP01375 (Uniprot-SwissProt)
Tjp1ProteinP39447 (Uniprot-SwissProt)
Uggt1GeneProductUggt1
Upf1ProteinQ9EPU0 (Uniprot-SwissProt)
VCANGeneProduct1462 (Entrez Gene)
Zmpste24ProteinQ80W54 (Uniprot-SwissProt)
mTORProteinP42345.1 (Uniprot-SwissProt)
mTORProteinQ9JLN9 (Uniprot-SwissProt)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5242"
Personal tools