HIPK2 in kidney fibrosis (Homo sapiens)

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1HIV infectionSIAH1Notch signalingHIPK2Wnt / B-catenin signalingTGF-B signalingp53 pathwayNF-kB signalingEpithelial-mesenchymaltransition markersKIDNEY FIBROSISApoptosisInflammationROSDNA damage


Description

This pathway shows the activation of multiple signaling pathways involved in kidney fibrosis, starting from an insult like HIV infection or oxidative stress, through the suppression of SIAH1 and increased expression of HIPK2. This pathway was adapted from Figure 6i of Jin et. al.

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Ontology Terms

 

Bibliography

  1. Jin Y, Ratnam K, Chuang PY, Fan Y, Zhong Y, Dai Y, Mazloom AR, Chen EY, D'Agati V, Xiong H, Ross MJ, Chen N, Ma'ayan A, He JC; ''A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.''; Nat Med, 2012 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
123418view06:12, 26 July 2022EgonwMade five pathways clickable
120779view22:23, 4 January 2022Khanspersupdated layout and pathway labels
120775view21:27, 4 January 2022KhanspersModified description
120774view20:16, 4 January 2022KhanspersModified description
108288view16:55, 4 December 2019AgustinGV
108287view16:54, 4 December 2019AgustinGV
108286view16:52, 4 December 2019AgustinGV
108025view21:15, 22 November 2019AgustinGV
108024view21:13, 22 November 2019AgustinGV
108023view21:10, 22 November 2019AgustinGV
108022view20:59, 22 November 2019AgustinGVOntology Term : 'renal fibrosis' added !
108021view20:58, 22 November 2019AgustinGVOntology Term : 'kidney disease pathway' added !
108019view20:55, 22 November 2019AgustinGVNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
HIPK2GeneProduct28996 (Entrez Gene)
NF-kB signalingPathwayWP4562 (WikiPathways)
Notch signalingPathwayWP268 (WikiPathways)
SIAH1GeneProduct6477 (Entrez Gene)
TGF-B signalingPathwayWP3874 (WikiPathways)
Wnt / B-catenin signalingPathwayWP4150 (WikiPathways)
p53 pathwayPathwayWP707 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4751"
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