T cell modulation in pancreatic cancer (Homo sapiens)

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T cell 1TAMPancreatic cancer cellStellate cell Antigen presenting cellT cell activationB2MHLA-DRBHLA-DRAOX40TRBPD-L1VEGFAVEGFCFAP-aB7-H4B7-H3CD40Gal-9IL10Gal-34-1BBPD-1HLA-AFAP-aGal-1TRAPGFTGFB1TGFB3CD40IDO1CD40-LUnknownCD28TGFB2UnknownVEGFDD-tryptophanCTLA-4VEGFBPD-L1KynurenineL-tryptophanCD86PD-L2CD804-1BB-LOX40LPD-1PD-1PD-L1CD40-LTGFB2TGFB1TGFB3IL10


Description

T cells are important effector cells in pancreatic cancer. Their function is inhibited by various cellular interactions and secreted factors in the tumor microenvironment (TME). Both immune cells and pancreatic cancer cells are able to modulate T cell activation. The pathway model is based on a review by Sideras et al., 2013 (DOI: 10.1016/j.ctrv.2013.11.005)

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Ontology Terms

 

Bibliography

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  1. Lyssiotis CA, Kimmelman AC; ''Metabolic Interactions in the Tumor Microenvironment.''; Trends Cell Biol, 2017 PubMed Europe PMC Scholia
  2. Wu Q, Tian Y, Zhang J, Zhang H, Gu F, Lu Y, Zou S, Chen Y, Sun P, Xu M, Sun X, Xia C, Chi H, Ying Zhu A, Tang D, Wang D; ''Functions of pancreatic stellate cell-derived soluble factors in the microenvironment of pancreatic ductal carcinoma.''; Oncotarget, 2017 PubMed Europe PMC Scholia
  3. Hou Z, Pan Y, Fei Q, Lin Y, Zhou Y, Liu Y, Guan H, Yu X, Lin X, Lu F, Huang H; ''Prognostic significance and therapeutic potential of the immune checkpoint VISTA in pancreatic cancer.''; J Cancer Res Clin Oncol, 2021 PubMed Europe PMC Scholia
  4. Liu X, Xu J, Zhang B, Liu J, Liang C, Meng Q, Hua J, Yu X, Shi S; ''The reciprocal regulation between host tissue and immune cells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications.''; Mol Cancer, 2019 PubMed Europe PMC Scholia
  5. Ren B, Cui M, Yang G, Wang H, Feng M, You L, Zhao Y; ''Tumor microenvironment participates in metastasis of pancreatic cancer.''; Mol Cancer, 2018 PubMed Europe PMC Scholia
  6. Sideras K, Braat H, Kwekkeboom J, van Eijck CH, Peppelenbosch MP, Sleijfer S, Bruno M; ''Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies.''; Cancer Treat Rev, 2013 PubMed Europe PMC Scholia
  7. Yang JS, Wang CC, Qiu JD, Ren B, You L; ''Arginine metabolism: a potential target in pancreatic cancer therapy.''; Chin Med J (Engl), 2020 PubMed Europe PMC Scholia
  8. Wang D, Gu Y, Yan X, Huo C, Wang G, Zhao Y, Teng M, Li Y; ''Role of CD155/TIGIT in Digestive Cancers: Promising Cancer Target for Immunotherapy.''; Front Oncol, 2022 PubMed Europe PMC Scholia
  9. Blair T, Baird J, Bambina S, Kramer G, Gostissa M, Harvey CJ, Gough MJ, Crittenden MR; ''ICOS is upregulated on T cells following radiation and agonism combined with radiation results in enhanced tumor control.''; Sci Rep, 2022 PubMed Europe PMC Scholia
  10. Goulart MR, Stasinos K, Fincham REA, Delvecchio FR, Kocher HM; ''T cells in pancreatic cancer stroma.''; World J Gastroenterol, 2021 PubMed Europe PMC Scholia
  11. Saka D, Gökalp M, Piyade B, Cevik NC, Arik Sever E, Unutmaz D, Ceyhan GO, Demir IE, Asimgil H; ''Mechanisms of T-Cell Exhaustion in Pancreatic Cancer.''; Cancers (Basel), 2020 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134371view13:24, 21 July 2024EgonwRemoved template comments
128646view20:00, 17 February 2024EweitzOntology Term : 'CD8-positive, alpha-beta T cell' added !
128645view19:58, 17 February 2024EweitzOntology Term : 'myeloid suppressor cell' added !
128644view19:57, 17 February 2024EweitzOntology Term : 'pancreatic stellate cell' added !
128643view19:57, 17 February 2024EweitzOntology Term : 'professional antigen presenting cell' added !
128642view19:55, 17 February 2024EweitzEconomize layout
125927view13:24, 20 March 2023IsabelWassinkMinor layout change
125923view11:07, 20 March 2023IsabelWassinkOntology Term : 'disease pathway' added !
125080view12:44, 20 January 2023IsabelWassinkOntology Term : 'malignant cell' added !
124823view09:24, 13 December 2022IsabelWassinkFixed TRAC, TRBC1 and TGFB1 data nodes for data visualization
124817view08:31, 12 December 2022IsabelWassinkupdated annotation of TRAC and TRBC1
124394view14:45, 25 October 2022IsabelWassinkNew data node names changed to official gene names
124389view11:38, 24 October 2022IsabelWassinkChanged the ARG1 data nodes to the official gene name
124388view11:24, 24 October 2022IsabelWassinkFixed the CCL17 and CCL22 data nodes
124387view10:50, 24 October 2022IsabelWassinkMistake in data node of CD226 fixed
124343view07:55, 18 October 2022IsabelWassinkAdded ICOS data node
124339view14:09, 17 October 2022IsabelWassinkModified description
124338view14:04, 17 October 2022IsabelWassinkNew data node with reference added
124327view11:58, 14 October 2022IsabelWassinkExtended the pathway
124316view10:45, 13 October 2022IsabelWassinkPathway extended with data nodes, interactions and references
124301view14:18, 11 October 2022IsabelWassinkChanged abbreviations into official gene names
124289view13:29, 10 October 2022IsabelWassinkCD155 and its receptors with added with references
124283view14:32, 7 October 2022IsabelWassinkNew data nodes and literature references added
124280view07:59, 7 October 2022IsabelWassinkUpdated the B7-H3 and B7-H4 interactions
124279view07:51, 7 October 2022IsabelWassinkModified title
124278view07:40, 7 October 2022IsabelWassinkModified description
124241view12:40, 5 October 2022IsabelWassinkChanged gene products to proteins and fixed the TCR and MHC complexes
124239view14:18, 4 October 2022IsabelWassinkOntology Term : 'pancreatic cancer pathway' added !
124237view12:32, 4 October 2022IsabelWassinkExtend pathway
118955view10:28, 5 June 2021EweitzOntology Term : 'T cell' added !
118954view10:27, 5 June 2021EweitzModified title
118953view10:26, 5 June 2021EweitzOntology Term : 'immune response pathway' added !
118952view10:26, 5 June 2021EweitzOntology Term : 'pancreatic cancer' added !
116146view14:56, 13 April 2021Mkutmonupdated species
116144view14:54, 13 April 2021DanaMustafaNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4-1BB-LProteinP41273 (Uniprot-TrEMBL)
4-1BBProteinQ07011 (Uniprot-TrEMBL)
B2MProteinP61769 (Uniprot-TrEMBL)
B7-H3ProteinQ5ZPR3 (Uniprot-TrEMBL)
B7-H4ProteinQ7Z7D3 (Uniprot-TrEMBL)
CD28ProteinP10747 (Uniprot-TrEMBL)
CD40-LProteinP29965 (Uniprot-TrEMBL)
CD40ProteinP25942 (Uniprot-TrEMBL)
CD80ProteinP33681 (Uniprot-TrEMBL)
CD86ProteinP42081 (Uniprot-TrEMBL)
CTLA-4ProteinP16410 (Uniprot-TrEMBL)
D-tryptophanMetaboliteCHEBI:57719 (ChEBI)
FAP-aProteinQ12884 (Uniprot-TrEMBL)
Gal-1ProteinP09382 (Uniprot-TrEMBL)
Gal-3ProteinP17931 (Uniprot-TrEMBL)
Gal-9ProteinO00182 (Uniprot-TrEMBL)
HLA-AProteinP04439 (Uniprot-TrEMBL)
HLA-DRAProteinP01903 (Uniprot-TrEMBL)
HLA-DRBProteinP01911 (Uniprot-TrEMBL)
IDO1ProteinP14902 (Uniprot-TrEMBL)
IL10ProteinP22301 (Uniprot-TrEMBL)
KynurenineMetaboliteCHEBI:28683 (ChEBI)
L-tryptophanMetaboliteCHEBI:57912 (ChEBI)
OX40LProteinP23510 (Uniprot-TrEMBL)
OX40ProteinP43489 (Uniprot-TrEMBL)
PD-1ProteinQ15116 (Uniprot-TrEMBL)
PD-L1ProteinQ9NZQ7 (Uniprot-TrEMBL)
PD-L2ProteinQ9BQ51 (Uniprot-TrEMBL)
PGFProteinP49763 (Uniprot-TrEMBL)
TGFB1ProteinP01137 (Uniprot-TrEMBL)
TGFB2ProteinP61812 (Uniprot-TrEMBL)
TGFB3ProteinP10600 (Uniprot-TrEMBL)
TRAProteinP0DSE1 (Uniprot-TrEMBL)
TRBProteinP0DSE2 (Uniprot-TrEMBL)
Unknown
VEGFAProteinP15692 (Uniprot-TrEMBL)
VEGFBProteinP49765 (Uniprot-TrEMBL)
VEGFCProteinP49767 (Uniprot-TrEMBL)
VEGFDProteinO43915 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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