Glycosphingolipid metabolism (Homo sapiens)

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2446357A4GALTGb3SM4Globo seriesB3GALT2B4GALT6GA2GLAA4GALTLc3CerLacCerNeolacto seriesARSAB4GALNT1GAL3ST1UGT8GlcCerGALCUGCGB4GALT5B4GALT4GBA1CDGGalCerSM3B4GALT3NEU4GM3GBA3GBA2LM1Gala-SeriesB3GALT1nLc4CerLacto seriesiGb3B4GALT1Ganglio seriesA3GALT2B3GNT5GM4CeramideNEU3ST3GAL513GAL3ST1ST3GAL5isoGlobo series


Description

Glycosphingolipid metabolism, based on sphingomap. Initial top level pathway

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Yamaguchi K, Hata K, Koseki K, Shiozaki K, Akita H, Wada T, Moriya S, Miyagi T; ''Evidence for mitochondrial localization of a novel human sialidase (NEU4).''; Biochem J, 2005 PubMed Europe PMC Scholia
  2. Honke K, Yamane M, Ishii A, Kobayashi T, Makita A; ''Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells.''; J Biochem, 1996 PubMed Europe PMC Scholia
  3. Wenger DA, Sattler M, Hiatt W; ''Globoid cell leukodystrophy: deficiency of lactosyl ceramide beta-galactosidase.''; Proc Natl Acad Sci U S A, 1974 PubMed Europe PMC Scholia
  4. Merril AH Jr; ''SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids.''; Glycobiology, 2005 PubMed Europe PMC Scholia
  5. Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU; ''Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  6. Yamashiro S, Haraguchi M, Furukawa K, Takamiya K, Yamamoto A, Nagata Y, Lloyd KO, Shiku H; ''Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  7. Kase R, Bierfreund U, Klein A, Kolter T, Utsumi K, Itoha K, Sandhoff K, Sakuraba H; ''Characterization of two alpha-galactosidase mutants (Q279E and R301Q) found in an atypical variant of Fabry disease.''; Biochim Biophys Acta, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134482view01:09, 22 July 2024EweitzOntology Term : 'lipid metabolic pathway' added !
125119view10:00, 24 January 2023Conroy lipidsadd ECs
124465view20:09, 29 October 2022EgonwCompleted the LM identifier
124460view07:49, 29 October 2022EgonwUpdated the UniProt data sources
124453view08:41, 28 October 2022Conroy lipids
124452view08:38, 28 October 2022Conroy lipids
124451view08:25, 28 October 2022Conroy lipids
124444view15:39, 27 October 2022Conroy lipids
124443view15:19, 27 October 2022Conroy lipids
124442view15:16, 27 October 2022Conroy lipidsfix broken links
124441view15:15, 27 October 2022Conroy lipidsfix non-touching nodes
124440view15:12, 27 October 2022Conroy lipidsupdate layout, add some back-reactions
124398view15:38, 25 October 2022Conroy lipidsfix unconnections
124397view15:34, 25 October 2022Conroy lipidsOntology Term : 'sphingolipid biosynthetic pathway' added !
124396view15:34, 25 October 2022Conroy lipidsOntology Term : 'ganglioside metabolic pathway' added !
124395view15:30, 25 October 2022Conroy lipidsadded some more data. Need to clean up layout considerably
124393view11:19, 25 October 2022Conroy lipidsNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
A3GALT2GeneProductU3KPV4 (Uniprot-SwissProt)
A4GALTGeneProductQ9NPC4 (Uniprot-TrEMBL)
ARSAGeneProductP15289 (Uniprot-TrEMBL)
B3GALT1GeneProductQ9Y5Z6 (Uniprot-TrEMBL)
B3GALT2GeneProductO43825 (Uniprot-TrEMBL)
B3GNT5GeneProductQ9BYG0 (Uniprot-TrEMBL)
B4GALNT1GeneProductQ00973 (Uniprot-TrEMBL)
B4GALT1GeneProductO60513 (Uniprot-TrEMBL)
B4GALT3GeneProductO60512 (Uniprot-TrEMBL)
B4GALT4GeneProductO60513 (Uniprot-TrEMBL)
B4GALT5GeneProductO43286 (Uniprot-TrEMBL)
B4GALT6GeneProductQ9UBX8 (Uniprot-TrEMBL)
CDGMetaboliteLMSP0509AA00 (LIPID MAPS)
CeramideMetaboliteLMSP02010000 (LIPID MAPS)
GA2MetaboliteLMSP0503AA00 (LIPID MAPS)
GAL3ST1GeneProductQ99999 (Uniprot-SwissProt)
GALCGeneProductP54803 (Uniprot-TrEMBL)
GBA1GeneProductP04062 (Uniprot-TrEMBL)
GBA2GeneProductQ9HCG7 (Uniprot-TrEMBL)
GBA3GeneProductQ9H227 (Uniprot-TrEMBL)
GLAGeneProductP06280 (Uniprot-TrEMBL)
GM3MetaboliteLMSP0601AJ00 (LIPID MAPS)
GM4MetaboliteLMSP0601AA00 (LIPID MAPS)
GalCerMetaboliteLMSP0501AC00 (LIPID MAPS)
Gala-SeriesPathway
Ganglio seriesPathway
Gb3MetaboliteMSP0502AA00 (LIPID MAPS)
GlcCerMetaboliteLMSP0501AA00 (LIPID MAPS)
Globo seriesPathway
LM1MetaboliteLMSP0504AB00 (LIPID MAPS)
LacCerMetaboliteLMSP0501AB00 (LIPID MAPS)
Lacto seriesPathway
Lc3CerMetaboliteLMSP0504AA00 (LIPID MAPS)
NEU3GeneProductQ9UQ49 (Uniprot-TrEMBL)
NEU4GeneProductQ8WWR8 (Uniprot-TrEMBL)
Neolacto seriesPathway
SM3MetaboliteLMSP0602AA00 (LIPID MAPS)
SM4MetaboliteLMSP0602AN00 (LIPID MAPS)
ST3GAL5GeneProductQ9UNP4 (Uniprot-TrEMBL)
UGCGGeneProductQ16739 (Uniprot-TrEMBL)
UGT8GeneProductQ16880 (Uniprot-TrEMBL)
iGb3MetaboliteLMSP0506AQ00 (LIPID MAPS)
isoGlobo seriesPathway
nLc4CerMetaboliteLMSP0505AA00 (LIPID MAPS)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
CeramideGalCermim-conversion13094 (Rhea)
CeramideGlcCermim-conversion12089 (Rhea)
GM3LacCermim-conversion47901 (Rhea)
GalCerCDGmim-conversion60061 (Rhea)
GalCerCeramidemim-conversion14298 (Rhea)
GalCerGM4mim-conversion47601 (Rhea)
GalCerSM4mim-conversion20614 (Rhea)
Gb3LacCermim-conversion21113 (Rhea)
GlcCerCeramidemim-conversion13270 (Rhea)
GlcCerLacCermim-conversion31496 (Rhea)
LacCerGA2mim-conversion47565 (Rhea)
LacCerGM3mim-conversion18418 (Rhea)
LacCerGlcCermim-conversion48061 (Rhea)
LacCerLc3Cermim-conversion13906 (Rhea)
LacCerSM3mim-conversion41737 (Rhea)
LacCeriGb3mim-conversion42001 (Rhea)
LacCermim-conversion11925 (Rhea)
Lc3CerLM1mim-conversion16046 (Rhea)
Lc3CernLc4Cermim-conversion31500 (Rhea)
SM4GalCermim-conversion21301 (Rhea)
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