Tetrahydrofolate biosynthesis I (Oryza sativa)

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cytosolH2OCRSM2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridinediphosphatedihydroneopterinaldolaseNADPHATPdihydroneopterinphosphateNADP+L-GludihydrofolatereductaseATPGTP cyclohydrolase I (LOC_OS04G56710.1)7,8-dihydroneopterin3'-triphosphatePiAMPL-GluPPiPPi7,8-dihydropteroate4-amino-4-deoxychorismateN-Formyl-GARglycolaldehydePYR2-amino-4-hydroxy-6-hydroxymethyldihydropteridinediphosphokinaseTHFHCOOHADPPi5,10-methenyl-THF10-formyl-THFphosphoribosylglycinamideformyltransferaseL-GlnH2OH2OH2OABENZGTPPRGADHFdihydroneopterindihydropteroatesynthaseH+


Description

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History

CompareRevisionActionTimeUserComment
124788view08:57, 11 December 2022EgonwReplaced a RiceCyc identifier with a matching UniProt id
118279view12:10, 26 May 2021EweitzModified title
82000view14:39, 8 September 2015Anweshafixing title, data source, & tagging incomplete pathways
80573view14:51, 25 June 2015AnweshaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Metabolite
10-formyl-THFMetaboliteCHEBI:15637 (ChEBI)
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphateMetaboliteCHEBI:15998 (ChEBI)
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinaseProtein1121789 (Reactome) Facilitates the conversion of 6-hydroxymethyl-dihydropterin to 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate.
4-amino-4-deoxychorismateMetaboliteCHEBI:18198 (ChEBI)
5,10-methenyl-THFMetaboliteCHEBI:15638 (ChEBI)
7,8-dihydroneopterin 3'-triphosphateMetaboliteCHEBI:18372 (ChEBI)
7,8-dihydropteroateMetaboliteCHEBI:4581 (ChEBI)
ABENZMetaboliteCHEBI:30753 (ChEBI)
ADPMetaboliteCHEBI:16761 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
CRSMMetaboliteCHEBI:17333 (ChEBI)
DHFMetaboliteCHEBI:15633 (ChEBI)
GTP cyclohydrolase I (LOC_OS04G56710.1)ProteinQ0J9B5 (Uniprot-TrEMBL) Facilitates the conversion of GTP to 7,8-dihydroneopterin 3'-triphosphate.
GTPMetaboliteCHEBI:15996 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HCOOHMetaboliteCHEBI:30751 (ChEBI)
L-GlnMetaboliteCHEBI:18050 (ChEBI)
L-GluMetaboliteCHEBI:16015 (ChEBI)
N-Formyl-GARMetaboliteCHEBI:18272 (ChEBI)
NADP+MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
PPiMetaboliteCHEBI:29888 (ChEBI)
PRGAMetaboliteCHEBI:18349 (ChEBI)
PYRMetaboliteCHEBI:32816 (ChEBI)
PiMetaboliteCHEBI:18367 (ChEBI)
THFMetaboliteCHEBI:15635 (ChEBI)
dihydrofolate reductaseProtein1121824 (Reactome) Facilitates the conversion of 7,8-dihydrofolate to tetrahydrofolate.
dihydroneopterin aldolaseProtein1121856 (Reactome) Facilitates the conversion of dihydro-neo-pterin to 6-hydroxymethyl-dihydropterin.
dihydroneopterin phosphateMetaboliteCHEBI:48954 (ChEBI)
dihydroneopterinMetaboliteCHEBI:17001 (ChEBI)
dihydropteroate synthaseProtein1121951 (Reactome) Facilitates the combination of p-aminobenzoate and 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate to form 7,8-dihydropteroate.
glycolaldehydeMetaboliteCHEBI:17071 (ChEBI)
phosphoribosylglycinamide formyltransferaseProtein1122195 (Reactome) Facilitates the conversion of N10-formyl-THF to tetrahydrofolate.

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
10-formyl-THF1121522 (Reactome)
10-formyl-THFArrow1120397 (Reactome)
1119912 (Reactome)
1120019 (Reactome) 7,8-dihydrofolate is converted to tetrahydrofolate by enzymatic activity of dihydrofolate reductase.
1120141 (Reactome) Dihydro-neo-pterin is converted to 6-hydroxymethyl-dihydropterin by enzymatic activity of dihydroneopterin aldolase.
1120209 (Reactome) 4-amino-4-deoxychorismate is converted to p-aminobenzoate by enzymatic activity of an unknown gene product.
1120397 (Reactome) 5,10-methenyl-THF is converted to N10-formyl-THF by enzymatic activity of an unknown gene product.
1120495 (Reactome)
1120572 (Reactome) Chorismate is converted to 4-amino-4-deoxychorismate by enzymatic activity of an unknown gene product.
1121346 (Reactome) 7,8-dihydroneopterin 3'-triphosphate is converted to dihydroneopterin phosphate by enzymatic activity of an unknown gene product.
1121366 (Reactome) 7,8-dihydropteroate is converted to 7,8-dihydrofolate by enzymatic activity of an unknown gene product.
1121496 (Reactome) Dihydroneopterin phosphate is converted to dihydro-neo-pterin by enzymatic activity of an unknown gene product.
1121522 (Reactome) N10-formyl-THF is converted to tetrahydrofolate by enzymatic activity of phosphoribosylglycinamide formyltransferase.
1121614 (Reactome) GTP is converted to 7,8-dihydroneopterin 3'-triphosphate by enzymatic activity of GTP cyclohydrolase I.
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate1120495 (Reactome)
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphateArrow1119912 (Reactome)
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinasemim-catalysis1119912 (Reactome)
4-amino-4-deoxychorismate1120209 (Reactome)
4-amino-4-deoxychorismateArrow1120572 (Reactome)
5,10-methenyl-THF1120397 (Reactome)
7,8-dihydroneopterin 3'-triphosphate1121346 (Reactome)
7,8-dihydroneopterin 3'-triphosphateArrow1121614 (Reactome)
7,8-dihydropteroate1121366 (Reactome)
7,8-dihydropteroateArrow1120495 (Reactome)
ABENZ1120495 (Reactome)
ABENZArrow1120209 (Reactome)
ADPArrow1121366 (Reactome)
AMPArrow1119912 (Reactome)
ATP1119912 (Reactome)
ATP1121366 (Reactome)
Arrow1120141 (Reactome)
CRSM1120572 (Reactome)
DHF1120019 (Reactome)
DHFArrow1121366 (Reactome)
GTP cyclohydrolase I (LOC_OS04G56710.1)mim-catalysis1121614 (Reactome)
GTP1121614 (Reactome)
H+1120019 (Reactome)
H2O1120397 (Reactome)
H2O1121346 (Reactome)
H2O1121496 (Reactome)
H2O1121614 (Reactome)
HCOOHArrow1121614 (Reactome)
L-Gln1120572 (Reactome)
L-Glu1121366 (Reactome)
L-GluArrow1120572 (Reactome)
N-Formyl-GARArrow1121522 (Reactome)
NADP+Arrow1120019 (Reactome)
NADPH1120019 (Reactome)
PPiArrow1120495 (Reactome)
PPiArrow1121346 (Reactome)
PRGA1121522 (Reactome)
PYRArrow1120209 (Reactome)
PiArrow1121366 (Reactome)
PiArrow1121496 (Reactome)
THFArrow1120019 (Reactome)
THFArrow1121522 (Reactome)
dihydrofolate reductasemim-catalysis1120019 (Reactome)
dihydroneopterin aldolasemim-catalysis1120141 (Reactome)
dihydroneopterin phosphate1121496 (Reactome)
dihydroneopterin phosphateArrow1121346 (Reactome)
dihydroneopterin1120141 (Reactome)
dihydroneopterinArrow1121496 (Reactome)
dihydropteroate synthasemim-catalysis1120495 (Reactome)
glycolaldehydeArrow1120141 (Reactome)
phosphoribosylglycinamide formyltransferasemim-catalysis1121522 (Reactome)
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