Globo series sphingolipid metabolism (Mus musculus)

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1, 2St3gal family141143114136Type IV A antigen445a3fucT family113SSEA-4 antigen446437B6glcnacT family405Sulfoglobotetraosylceramide444447Type IV B antigen131135449134GB3Galbeta1-3(Galbeta1-4GlcNAcbeta1-6)GalNAcbeta1-3Galalpha1-4Galbeta1-4Glcbeta-Certype IV HGbgt1Fut2a3GalT familyB3galt5144Galbeta1-3(GlcNAcbeta1-6)GalNAcbeta1-3Galalpha1-4Galbeta1-4Glcbeta-Cer403Globopentaosylceramide sulfate137145448442111441139Branched ForssmanForssman antigen440115443146Para-Forssman x3bB4galt family414112SSEA-3 antigenB3galnt1Globoside IGB4Cer132406SSEA-4 isomer436450140globo-Lex-9 a3GalNAcTfamily142439438138110133


Description

Globoseries sphingolipid biosynthesis taken from Sphingomap.

Solid conversion arrows are documented according to Sphingomap. Thicker lines are those reactions not found in Rhea. Dotted conversions are hypothetical, either not occurring or undocumented (Sphingomap details all possible permutations of a pathway to the final glycolipid) p Numbers are the sphingomap IDs, to be converted.

Metabolites with a dotted box are hypothetical. These may or may not exist on the pathway to the final product as several different routes could occur.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Merril AH Jr; ''SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids.''; Glycobiology, 2005 PubMed Europe PMC Scholia
  2. ''Handbook of Glycosyltransferases and Related Genes''; https://doi.org/10.1007/978-4-431-67877-9, 2002 DOI Scholia

History

View all...
CompareRevisionActionTimeUserComment
125906view15:13, 17 March 2023JmillanacostaAnnotation connection
125832view06:36, 13 March 2023EgonwThat was not a LM identifier
125109view13:04, 23 January 2023Conroy lipidsadded a Rhea, some ECs
124887view13:49, 29 December 2022EgonwManually added the DOI identifier as identifier too
124878view20:28, 19 December 2022Conroy lipids
124877view20:27, 19 December 2022Conroy lipidsaddmissing hypotetical conversion
124876view17:59, 19 December 2022Conroy lipidsModified description
124875view17:51, 19 December 2022Conroy lipidsadded all componets for sphingomap of this pathway
124830view15:26, 13 December 2022Conroy lipids
124829view15:25, 13 December 2022Conroy lipids
124828view15:21, 13 December 2022Conroy lipidsfix odd symbols, missing link
124827view14:45, 13 December 2022Conroy lipidsOntology Term : 'globoside metabolic pathway' added !
124826view14:44, 13 December 2022Conroy lipidsOntology Term : 'lipid metabolic pathway' added !
124825view14:42, 13 December 2022Conroy lipidsremove odd symbols from title
124824view13:59, 13 December 2022Conroy lipidsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
110MetaboliteLMSP0502AL00 (LIPID MAPS)
111MetaboliteLMSP0502AM00 (LIPID MAPS)
113MetaboliteLMSP0601AC00 (LIPID MAPS)
114MetaboliteLMSP0601AD00 (LIPID MAPS)
115MetaboliteLMSP0601AE00 (LIPID MAPS)
131MetaboliteLMSP0502AO00 (LIPID MAPS)
132MetaboliteLMSP0502AP00 (LIPID MAPS)
135MetaboliteLMSP0601AF00 (LIPID MAPS)
136MetaboliteLMSP0601AG00 (LIPID MAPS)
137MetaboliteLMSP0601AH00 (LIPID MAPS)
138MetaboliteLMSP0502AS00 (LIPID MAPS)
139 Branched ForssmanMetaboliteLMSP0502AT00 (LIPID MAPS)
140MetaboliteLMSP0502AU00 (LIPID MAPS)
141MetaboliteLMSP0502BA00 (LIPID MAPS)
142MetaboliteLMSP0502AV00 (LIPID MAPS)
403 Globopentaosylceramide sulfateMetaboliteLMSP0602AB00 (LIPID MAPS)
405 SulfoglobotetraosylceramideMetaboliteLMSP0602AC00 (LIPID MAPS)
406 SSEA-4 isomerMetaboliteLMSP0601AI00 (LIPID MAPS)
414MetaboliteLMSP0502BB00 (LIPID MAPS)
436MetaboliteLMSP0502BC00 (LIPID MAPS)
438MetaboliteLMSP0502BD00 (LIPID MAPS)
441MetaboliteLMSP0502BE00 (LIPID MAPS)
442MetaboliteLMSP0502BF00 (LIPID MAPS)
443MetaboliteLMSP0502BG00 (LIPID MAPS)
444MetaboliteLMSP0502BH00 (LIPID MAPS)
445MetaboliteLMSP0502BI00 (LIPID MAPS)
446MetaboliteLMSP0502BJ00 (LIPID MAPS)
447MetaboliteLMSP0502BK00 (LIPID MAPS)
448MetaboliteLMSP0502BL00 (LIPID MAPS)
449MetaboliteLMSP0502BM00 (LIPID MAPS)
450MetaboliteLMSP0502BN00 (LIPID MAPS)
B3galnt1GeneProductQ920V1 (Uniprot-TrEMBL)
B3galt5GeneProductQ9JI67 (Uniprot-TrEMBL)
B4galt familyGeneProduct EC:2.4.1.22
B6glcnacT familyProteinEC:
Forssman antigenMetaboliteLMSP0502AC00 (LIPID MAPS)
Fut2GeneProductQ9JL27 (Uniprot-TrEMBL)
GB3MetaboliteLMSP0502AA00 (LIPID MAPS)
Galbeta1-3(Galbeta1-4GlcNAcbeta1-6)GalNAcbeta1-3Galalpha1-4Galbeta1-4Glcbeta-CerMetaboliteLMSP0502AG00 (LIPID MAPS) sphingomap id 23
Galbeta1-3(GlcNAcbeta1-6)GalNAcbeta1-3Galalpha1-4Galbeta1-4Glcbeta-Cer MetaboliteLMSP0502AF00 (LIPID MAPS)
Gbgt1GeneProductQ8VI38 (Uniprot-TrEMBL)
Globoside I GB4CerMetaboliteLMSP0502AB00 (LIPID MAPS) S_id 18
Para-Forssman x3bMetaboliteLMSP0502AD00 (LIPID MAPS) S_id 20
SSEA-3 antigen MetaboliteLMSP0502AE00 (LIPID MAPS) sphingomap id 21
SSEA-4 antigenMetaboliteLMSP0601AB00 (LIPID MAPS)
St3gal familyProtein
Type IV A antigenMetaboliteLMSP0502AJ00 (LIPID MAPS)
Type IV B antigenMetabolitetype IV B antigen (LIPID MAPS)
a3GalNAcT familyProtein
a3GalT familyProtein
a3fucT familyGeneProduct
globo-Lex-9 MetaboliteLMSP0502AH00 (LIPID MAPS) Sphingomap_id 25
type IV HMetaboliteLMSP0502AI00 (LIPID MAPS) Sphingomap id 26
112Metabolite
133Metabolite
134Metabolite
143Metabolite
144Metabolite
145Metabolite
146Metabolite
437Metabolite
439Metabolite
440Metabolite

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
B3galnt1mim-catalysis22253 (Rhea) EC:2.4.1.79
GB3Globoside I GB4Cermim-conversion22253 (Rhea)
Globoside I GB4CerForssman antigenmim-conversion22165 (Rhea) EC:2.4.1.88
Globoside I GB4CerGB3mim-conversion48037 (Rhea)
Globoside I GB4CerSSEA-3 antigen mim-conversion41997 (Rhea)
SSEA-3 antigen type IV Hmim-conversion42045 (Rhea) EC:2.4.1.69
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