Fatty acid biosynthesis (Bos taurus)

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Malonyl-ACP3-ketoacyl-CoATCA CycleCitrate3-L-Hydroxyacyl-CoACrotonoyl-ACPCytosolAcetoacetyl-ACPOxaloacetateFatty acyl CoALong-Chain fatty acidtrans-delta2-enoyl-CoAPyruvateMitochondrionbeta-hydroxybutyryl6 iterationsPalmitateButyryl-ACPless than 6 iterationsAcetyl-synthasePalmitoyl-ACPAcetyl-ACPACACBFASNPCAcetyl-CoAACAA2ACACAFASNPECRFASNACLYFASNDECR1ECHS1FASNFASNFASNMECRTriacylglyceride Synthesis pathwayHADHECH1ACSL5Malonyl-CoAACSL4ECHDC1ECHDC2FASNSCDAcyl-CoA (n+2)ECHDC3ACSL3ACSL6ACSS2ACSL1


Description

The production of fatty acids from acetyl-CoA and NADPH through the use of enzymes known as fatty acid synthases is referred to as fatty acid synthesis. This biological process occurs within the cytoplasm of cells. The majority of acetyl-CoA that is transformed into fatty acids originates from carbohydrates through the glycolytic pathway.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP357(70641) with a 96.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
125343view19:38, 3 February 2023AlexanderPicoModified description
125091view23:21, 20 January 2023AlexanderPicofixed typo
125090view23:20, 20 January 2023AlexanderPicoadded description
124922view22:47, 31 December 2022EgonwFixed the AcylCoA identifier
120929view08:06, 1 February 2022EgonwMade two pathways clickable
117511view11:06, 21 May 2021EweitzModified title
80794view15:26, 30 June 2015Mkutmonhomology conversion
79158view05:09, 6 March 2015MaintBotModified description
79157view05:08, 6 March 2015MaintBotUpdated conversion from Hs
71425view19:02, 17 October 2013MaintBotAutomated update of data sources
63446view17:14, 10 May 2013MaintBotUpdated to 2013 gpml schema
40580view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
33817view00:23, 9 December 2009MaintBotAutomatic update of empty xrefs
31661view11:39, 14 August 2009MaintBotFixed group labels
30589view22:12, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACAA2GeneProductENSBTAG00000002863 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10449
ACACAGeneProduct
ACACBGeneProductENSBTAG00000022058 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:32
ACLYGeneProductENSBTAG00000016740 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:47
ACSL1GeneProductENSBTAG00000004344 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2180
ACSL3GeneProductENSBTAG00000017258 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2181
ACSL4GeneProductENSBTAG00000018986 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2182
ACSL5GeneProductENSBTAG00000006707 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51703
ACSL6GeneProductENSBTAG00000019708 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23305
ACSS2GeneProductENSBTAG00000013303 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55902
Acetyl-CoAMetabolite72-89-9 (CAS)
Acyl-CoA (n+2)MetaboliteCHEBI:17984 (ChEBI)
CitrateMetabolite29081 (Chemspider)
DECR1GeneProductENSBTAG00000019663 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1666
ECH1GeneProductENSBTAG00000016313 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1891
ECHDC1GeneProductENSBTAG00000003887 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55862
ECHDC2GeneProductENSBTAG00000002910 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55268
ECHDC3GeneProductENSBTAG00000012377 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:79746
ECHS1GeneProductENSBTAG00000017710 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1892
FASNGeneProductENSBTAG00000015980 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2194
HADHGeneProductENSBTAG00000002049 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3033
Long-Chain fatty acidMetaboliteCHEBI:15904 (ChEBI)
MECRGeneProductENSBTAG00000017253 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51102
Malonyl-CoAMetabolite524-14-1 (CAS)
OxaloacetateMetabolite2509917 (Chemspider)
PCGeneProductENSBTAG00000019700 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5091
PECRGeneProductENSBTAG00000006821 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55825
PalmitateMetabolite440215 (Chemspider)
PyruvateMetabolite96901 (Chemspider)
SCDGeneProductENSBTAG00000047957 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6319
TCA CyclePathwayWP78 (WikiPathways)
Triacylglyceride Synthesis pathwayPathwayWP325 (WikiPathways)

Annotated Interactions

No annotated interactions
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