Cardiomyocyte signaling converging on titin (Homo sapiens)

From WikiPathways

Revision as of 11:04, 17 March 2023 by Bep3.14e (Talk | contribs)
Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none M-bandTTNTKTTNPEVKPTTNN2APTTNN2BPTTNTitin domainsZ-discTTNTTNTTNHypertrophic signallingNPR1GUCD1calcium(2+)Protein Quality ControlPRKAR1APRKACBPRKACAPRKACGGTP(4 - )ANKRD23ANKRD1MYPNANKRD2FHL1FHL2NOSRFTRIM55TRIM63GUCY1B1TCAPMAPK1RASMAP2K1MAP2K2RAF1PRKCACSRP3CAMK2APRKG23',5'-cyclic GMPNBR1NUP623',5'-cyclic AMPCapn1CRYABATPFHL2MDM2GPCRPLCZ1ADRB2ADRB1adenylyl cyclaseName: Cardiomyocyte signaling pathways converging on TitinOrganism: Homo sapiens


Description

Cardiac titin phosphorylation and its involvement in Protein Quality Control pathways as well as Hypertrophic Signalling.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

Bibliography

  1. Linke WA, Hamdani N; ''Gigantic business: titin properties and function through thick and thin.''; Circ Res, 2014 PubMed Europe PMC Scholia
  2. Linke, WA, Krüger, Martina; ''The giant protein titin: a regulatory node that integrates myocyte signaling pathways.''; J Biol Chem, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129750view01:58, 22 May 2024EweitzModified title
128794view01:41, 22 February 2024EweitzModified description
128793view01:41, 22 February 2024EweitzOntology Term : 'cardiac muscle cell' added !
128792view01:40, 22 February 2024EweitzModified title
128787view00:22, 22 February 2024EweitzStandardize nomenclature, case
125919view05:55, 20 March 2023EgonwUpdated two UniProt data sources
125904view14:13, 17 March 2023JmillanacostaFixed citation (encoded characters)
125901view11:17, 17 March 2023SnnrrdcOntology Term : 'signaling pathway' added !
125900view11:17, 17 March 2023SnnrrdcOntology Term : 'Ras superfamily mediated signaling pathway' added !
125899view11:13, 17 March 2023Isa LeendersModified description
125898view11:09, 17 March 2023Isa LeendersModified title
125897view11:05, 17 March 2023Bep3.14eIncorrect TTN node was removed.
125896view11:04, 17 March 2023Bep3.14eTitle was changed to a more descriptive one. Gene names and Node labels were corrected. Layout was changed for visual clarification. Arrow/line types and styles were updated.
125866view14:16, 14 March 2023Bep3.14eUnused data nodes were removed and a pathway title was added.
125865view14:13, 14 March 2023Bep3.14eNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
3',5'-cyclic AMPMetaboliteCHEBI:17489 (ChEBI)
3',5'-cyclic GMPMetaboliteCHEBI:16356 (ChEBI)
ADRB1GeneProductP08588 (Uniprot-TrEMBL)
ADRB2GeneProductP07550 (Uniprot-TrEMBL)
ANKRD1GeneProductENSG00000148677 (Ensembl)
ANKRD23GeneProductENSG00000163126 (Ensembl)
ANKRD2GeneProductENSG00000165887 (Ensembl)
ATPMetaboliteCHEBI:30616 (ChEBI)
CAMK2AGeneProductENSG00000070808 (Ensembl)
CRYABGeneProductP02511 (Uniprot-TrEMBL)
CSRP3GeneProductENSG00000129170 (Ensembl)
Capn1GeneProductQ3TB79 (Uniprot-SwissProt)
FHL1GeneProductQ13642 (Uniprot-TrEMBL)
FHL2GeneProductQ14192 (Uniprot-TrEMBL)
GPCRGeneProductQ8TDU1 (Uniprot-TrEMBL)
GTP(4 - )MetaboliteCHEBI:37565 (ChEBI)
GUCD1GeneProductENSG00000138867 (Ensembl)
GUCY1B1GeneProductENSG00000061918 (Ensembl)
Hypertrophic signallingPathway
MAP2K1GeneProductQ02750 (Uniprot-TrEMBL)
MAP2K2GeneProductP36507 (Uniprot-TrEMBL)
MAPK1GeneProductENSG00000100030 (Ensembl)
MDM2GeneProductQ00987 (Uniprot-TrEMBL)
MYPNGeneProductENSG00000138347 (Ensembl)
NBR1GeneProductQ14596 (Uniprot-TrEMBL)
NOMetaboliteCHEBI:16480 (ChEBI)
NPR1GeneProductP16066 (Uniprot-SwissProt)
NUP62GeneProductP37198 (Uniprot-TrEMBL)
PLCZ1GeneProductENSG00000139151 (Ensembl)
PRKACAGeneProductP17612 (Uniprot-TrEMBL)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKAR1AGeneProductENSG00000108946 (Ensembl)
PRKCAGeneProductENSG00000154229 (Ensembl)
PRKG2GeneProductQ13237 (Uniprot-TrEMBL)
Protein Quality ControlPathway
RAF1GeneProductP04049 (Uniprot-TrEMBL)
RASGeneProductP01114 (Uniprot-TrEMBL)
SRFGeneProductP11831 (Uniprot-TrEMBL)
TCAPGeneProductENSG00000173991 (Ensembl)
TRIM55GeneProductQ9BYV6 (Uniprot-TrEMBL)
TRIM63GeneProductQ969Q1 (Uniprot-TrEMBL)
TTNGeneProductENSG00000155657 (Ensembl)
adenylyl cyclaseGeneProductQ59FG4 (Uniprot-TrEMBL)
calcium(2+)MetaboliteCHEBI:29108 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5344"
Personal tools