Iron-sulfur cluster biogenesis (Homo sapiens)

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21Mitochondrial Fe-S proteinsL-cysteineLYRM4e-ISCUNFS1FXNS[4Fe-4S] clusterFeFDX1FDXRABCB7HSPA9HSCBGLRX5NUBP2NUBP1NARFCIAO1CIAO2BFXNNFU1NFS1ISCUFeFeFe[4Fe-4S] clusterCytosolicFe-S proteinsISCU


Description

This pathway was modeled based on Fig 2a from Rouault and Tong.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Friemel M, Marelja Z, Li K, Leimkühler S; ''The N-Terminus of Iron-Sulfur Cluster Assembly Factor ISD11 Is Crucial for Subcellular Targeting and Interaction with l-Cysteine Desulfurase NFS1.''; Biochemistry, 2017 PubMed Europe PMC Scholia
  2. Rouault TA, Tong WH; ''Iron-sulfur cluster biogenesis and human disease.''; Trends Genet, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
125997view18:20, 24 March 2023KhanspersOntology Term : 'regulatory pathway' added !
125989view18:12, 23 March 2023KhanspersModified description
125986view18:06, 23 March 2023Khansperslatest - updated xrefs
125985view18:04, 23 March 2023KhanspersReverted to version '17:47, 23 March 2023' by Khanspers
125984view18:03, 23 March 2023Khansperslatest - updated xrefs
125983view17:47, 23 March 2023KhanspersModified description
125982view17:31, 23 March 2023KhanspersModified description
125981view17:31, 23 March 2023Khanspersupdate with latest
120555view00:20, 15 December 2021KhanspersOntology Term : 'iron-sulfur cluster protein biogenesis pathway' added !
120554view00:19, 15 December 2021KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCB7GeneProductENSG00000131269 (Ensembl)
CIAO1GeneProductENSG00000144021 (Ensembl)
CIAO2BGeneProduct51647 (Entrez Gene)
FDX1GeneProduct2230 (Entrez Gene)
FDXRGeneProduct2232 (Entrez Gene)
FXNGeneProduct2395 (Entrez Gene)
FeMetaboliteCHEBI:18248 (ChEBI)
GLRX5GeneProduct51218 (Entrez Gene)
HSCBGeneProduct150274 (Entrez Gene)
HSPA9GeneProduct3313 (Entrez Gene)
ISCUGeneProduct23479 (Entrez Gene)
L-cysteineMetaboliteCHEBI:17561 (ChEBI)
LYRM4GeneProduct57128 (Entrez Gene)
NARFGeneProduct26502 (Entrez Gene)
NFS1GeneProduct9054 (Entrez Gene)
NFU1GeneProduct27247 (Entrez Gene)
NUBP1GeneProductENSG00000103274 (Ensembl)
NUBP2GeneProduct10101 (Entrez Gene)
SMetaboliteCHEBI:26833 (ChEBI)
[4Fe-4S] clusterMetaboliteCHEBI:49883 (ChEBI)
e-MetaboliteCHEBI:10545 (ChEBI)

Annotated Interactions

No annotated interactions

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