IL26 signaling (Homo sapiens)

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DegradationInhibitionLEGENDMacrophage differentiationin RAW264.7 cells Suppression of EGFR-TKI-induced endoplasmic reticulum (ER) stressAsthmaIL-10R2IL-20R1JAK2P3Nos2Cd8011Tnf11TGFB111SMAD26CASP36cleaved CASP36BAX6IL666IL10TNF66MMP9ACTA266Supresses apoptosis and promotes liver fibrosis of hepatic stellate cells (HSCs) MAPK3T2022, 4, 5, 8, 13T183MAPK1Y2042, 4, 5, 8Y185MAPK82, 4, 5, 8, 12Y185T183MAPK14T180Y1822, 5, 8STAT1S7271-5, 8Y701Y705COX25MMP1IL65Induces proinflammatory effects in human articularchondrocytes (HACs), keratinocytes and colonic subepithelial myofibroblasts/adenocarcinoma 2, 5NFKBIA8PSTAT3S727Y7051-4, 8, 13TNFSF11 8TRAP8OCSTAMPATP6V0D28CTSK8 NFATC188DCSTAMP8Involved in osteoclastogenesis in RA (rheumatoid arthritis) fibroblast-like synoviocytes (FLSs) IL-26EPHA3 1212AKT1S4732, 12DDIT3 12IL1BIL61010TNF10IL17A10RORC10IL-26 overexpressioninduces proinflammation in asthmatic patients RELACXCL8P2, 11MAPK91, 2, 4T1832, 4Y185TNFCcl34Mpo99Mmp9Mmp299Tnf9Ccl209Cxcl2Csf9Facilitates innate immune response in bronchoalveolar space of mice9JAK13PTYK23PIL83IL1B3CCL20IL333DEFB43Il433Il133Il33Il17a33Ccl203Involved in human epidermal keratinocytes Atopic dermatitisIL84 SOCS34CXCL8IL1B7TNF77STAT17STAT37CSF27MPO7Involved in antibacterial host defenseIL101ICAM11LigandProteinmRNARegulation of protein/gene expressionLeads to multple reactionsProteinPPhosphorylation site modificationGene/ProteinUpregulationDownregulationInduces antiapoptosis and tumor growth in murine and human TNBC cellsPIK3CA2PRELA2, 11Il6P11Il1011IL-26Gene/ProteinLeads to EPHA3 mediated signalingReceptor 1Receptor 2Liver fibrosisRheumatoid arthritisJUNS732, 5


Description

A comprehensive network map of IL-26 signaling pathway

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Ontology Terms

 

Bibliography

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  1. Chen YT, Wang CC, Cheng CP, Liu FC, Lee CH, Lee HS, Peng YJ; ''Interleukin-26 Has Synergistic Catabolic Effects with Palmitate in Human Articular Chondrocytes via the TLR4-ERK1/2-c-Jun Signaling Pathway.''; Cells, 2021 PubMed Europe PMC Scholia
  2. Dambacher J, Beigel F, Zitzmann K, De Toni EN, Goke B, Diepolder HM, Auernhammer CJ, Brand S; ''The role of the novel Th17 cytokine IL-26 in intestinal inflammation.''; Gut, 2009 PubMed Europe PMC Scholia
  3. Fujii M, Nishida A, Imaeda H, Ohno M, Nishino K, Sakai S, Inatomi O, Bamba S, Kawahara M, Shimizu T, Andoh A; ''Expression of Interleukin-26 is upregulated in inflammatory bowel disease.''; World J Gastroenterol, 2017 PubMed Europe PMC Scholia
  4. Bao A, Che KF, Bozinovski S, Ji J, Gregory JA, Georen SK, Adner M, Cardell LO, Linden A; ''Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo.''; PLoS One, 2017 PubMed Europe PMC Scholia
  5. Zhang X, Xie X, Wang Y, Li W, Lin Z; ''Interleukin-26 promotes the proliferation and activation of hepatic stellate cells to exacerbate liver fibrosis by the TGF-B1/Smad2 signaling pathway.''; Int J Clin Exp Pathol, 2019 PubMed Europe PMC Scholia
  6. Louhaichi S, Mlika M, Hamdi B, Hamzaoui K, Hamzaoui A; ''Sputum IL-26 Is Overexpressed in Severe Asthma and Induces Proinflammatory Cytokine Production and Th17 Cell Generation: A Case-Control Study of Women.''; J Asthma Allergy, 2020 PubMed Europe PMC Scholia
  7. Mayer P, Linnebacher A, Glennemeier-Marke H, Marnet N, Bergmann F, Hackert T, Klauss M, Poth T, Gaida MM; ''The Microarchitecture of Pancreatic Cancer as Measured by Diffusion-Weighted Magnetic Resonance Imaging Is Altered by T Cells with a Tumor Promoting Th17 Phenotype.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
  8. Lee KA, Kim KW, Kim BM, Won JY, Min HK, Lee DW, Kim HR, Lee SH; ''Promotion of osteoclastogenesis by IL-26 in rheumatoid arthritis.''; Arthritis Res Ther, 2019 PubMed Europe PMC Scholia
  9. Lin YH, Wang YH, Peng YJ, Liu FC, Lin GJ, Huang SH, Sytwu HK, Cheng CP; ''Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-kB Pathway.''; Cells, 2020 PubMed Europe PMC Scholia
  10. Che KF, Tengvall S, Levanen B, Silverpil E, Smith ME, Awad M, Vikstrom M, Palmberg L, Qvarfordt I, Skold M, Linden A; ''Interleukin-26 in antibacterial host defense of human lungs. Effects on neutrophil mobilization.''; Am J Respir Crit Care Med, 2014 PubMed Europe PMC Scholia
  11. Hor S, Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, Renauld JC, de Waal Malefyt R, Fickenscher H; ''The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  12. Itoh T, Hatano R, Horimoto Y, Yamada T, Song D, Otsuka H, Shirakawa Y, Mastuoka S, Iwao N, Aune TM, Dang NH, Kaneko Y, Okumura K, Morimoto C, Ohnuma K; ''IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells.''; Cell Death Dis, 2021 PubMed Europe PMC Scholia
  13. Kamijo H, Miyagaki T, Hayashi Y, Akatsuka T, Watanabe-Otobe S, Oka T, Shishido-Takahashi N, Suga H, Sugaya M, Sato S; ''Increased IL-26 Expression Promotes T Helper Type 17- and T Helper Type 2-Associated Cytokine Production by Keratinocytes in Atopic Dermatitis.''; J Invest Dermatol, 2020 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129744view01:55, 22 May 2024EweitzModified title
126468view05:51, 2 May 2023EgonwNot mim-conversions
126466view04:46, 2 May 2023EgonwBinding instead?
126456view20:24, 30 April 2023AlexanderPicoremoved more data-coded color
126455view20:21, 30 April 2023AlexanderPicoremoved data-coded color; replaced datanodes in legend
126454view20:05, 30 April 2023AlexanderPicofixed citations
126072view22:35, 31 March 2023KhanspersOntology Term : 'interleukin-6 signaling pathway' added !
126071view22:35, 31 March 2023KhanspersOntology Term : 'signaling pathway' added !
126019view07:49, 27 March 2023Rex D A B
126018view07:48, 27 March 2023Rex D A B
126017view07:43, 27 March 2023Rex D A B
126016view07:25, 27 March 2023Rex D A B
126015view05:31, 27 March 2023Rex D A B
126014view05:25, 27 March 2023Rex D A B
126013view05:19, 27 March 2023Rex D A B
126010view10:29, 26 March 2023EgonwUpdated the UniProt data sources
126009view13:48, 25 March 2023Rex D A B
126008view13:41, 25 March 2023Rex D A B
126007view11:39, 25 March 2023Rex D A BMolecule rearrangement
126006view11:01, 25 March 2023Rex D A BPathway arrangement
126003view07:32, 25 March 2023Rex D A BNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
NFATC1GeneProduct4772 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
ACTA2GeneProduct59 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
ATP6V0D2GeneProduct245972 (Entrez Gene)
BAXGeneProduct581 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CCL20GeneProduct6364 (Entrez Gene)
COX2ProteinP00403 (Uniprot-SwissProt)
CSF2GeneProduct1437 (Entrez Gene)
CTSKGeneProduct1513 (Entrez Gene)
CXCL8GeneProduct3576 (Entrez Gene)
Ccl20GeneProduct20297 (Entrez Gene)
Ccl3ProteinP10855 (Uniprot-SwissProt)
Cd80GeneProduct12519 (Entrez Gene)
CsfGeneProduct12977 (Entrez Gene)
Cxcl2GeneProduct20310 (Entrez Gene)
DCSTAMPGeneProduct81501 (Entrez Gene)
DDIT3 ProteinP35638 (Uniprot-SwissProt)
DEFB4GeneProduct1673 (Entrez Gene)
EPHA3 ProteinP29320 (Uniprot-SwissProt)
Gene/ProteinRna
ICAM1GeneProduct3383 (Entrez Gene)
IL-10R2ProteinQ08334 (Uniprot-SwissProt)
IL-20R1ProteinQ9UHF4 (Uniprot-SwissProt)
IL-26ProteinQ9NPH9 (Uniprot-SwissProt)
IL10GeneProduct3586 (Entrez Gene)
IL17AGeneProduct3605 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL1BProteinP01584 (Uniprot-SwissProt)
IL33GeneProduct90865 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL6ProteinP05231 (Uniprot-SwissProt)
IL8GeneProduct3576 (Entrez Gene)
IL8ProteinP10145 (Uniprot-SwissProt)
Il10Protein16153 (Entrez Gene)
Il13GeneProduct16163 (Entrez Gene)
Il17aGeneProduct16171 (Entrez Gene)
Il33GeneProduct77125 (Entrez Gene)
Il4GeneProduct16189 (Entrez Gene)
Il6Protein16193 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
LigandProtein
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MMP1ProteinP03956 (Uniprot-SwissProt)
MMP9GeneProduct4318 (Entrez Gene)
MPOProteinP05164 (Uniprot-SwissProt)
Mmp2ProteinP33434 (Uniprot-SwissProt)
Mmp9ProteinP41245 (Uniprot-SwissProt)
MpoProteinP11247 (Uniprot-SwissProt)
NFKBIAProtein4792 (Entrez Gene)
Nos2GeneProduct18126 (Entrez Gene)
OCSTAMPGeneProduct74614 (Entrez Gene)
PIK3CAProtein5290 (Entrez Gene)
ProteinProtein
RELAProtein5970 (Entrez Gene)
RELAProteinQ04206 (Uniprot-SwissProt)
RORCGeneProduct6097 (Entrez Gene)
Receptor 1w (WikiPathways)
Receptor 2ProteinQ9UHF4 (Uniprot-SwissProt)
SMAD2ProteinQ15796 (Uniprot-SwissProt)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TGFB1ProteinP01137 (Uniprot-SwissProt)
TNFGeneProduct7124 (Entrez Gene)
TNFProteinP01375 (Uniprot-SwissProt)
TNFSF11 GeneProduct8600 (Entrez Gene)
TRAPGeneProduct100187907 (Entrez Gene)
TYK2Protein7297 (Entrez Gene)
TnfGeneProduct21926 (Entrez Gene)
cleaved CASP3GeneProduct836 (Entrez Gene)
mRNARna

Annotated Interactions

No annotated interactions

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