IL26 signaling (Homo sapiens)

From WikiPathways

Revision as of 05:31, 27 March 2023 by Rex D A B (Talk | contribs)
Jump to: navigation, search
Suppression of EGFR-TKI-induced endoplasmic reticulum (ER) stressInhibitionLEGENDMacrophage differentiationin RAW264.7 cells NUIL-26 exacerbates liver fibrosis by promoting the proliferation and activation of hepatic stellate cellsHeterodimeric receptor complexAsthmaIL10R2IL20R1JAK2P6Nos2Cd8010Tnf1010TGFB1SMAD22CASP32cleaved CASP32BAX22IL62IL10TNF22MMP9ACTA222Supresses apoptosis and promotes liver fibrosis of hepatic stellate cells (HSCs) MAPK3MAPK1T2021, 3, 5, 11, 12Y204Y1873, 5, 11, 12T185MAPK8T1833, 5, 8, 11, 12Y185MAPK14Y1823, 5, 11T180STAT1Y705Y7013, 5, 6, 11-13S727COX2MMP15IL65Induces proinflammatory effects in human articularchondrocytes (HACs), keratinocytes and colonic subepithelial myofibroblasts/adenocarcinoma 5, 11NFKBIA3S32STAT3S7271, 3, 6, 11-13Y705TNFSF11 3TRAPOCSTAMP3ATP6V0D233CTSK NFATC13DCSTAMP33Involved in osteoclastogenesis in RA (rheumatoid arthritis) fibroblast-like synoviocytes (FLSs) IL26EPHA3 88AKT18, 11S73DDIT3 8IL1B7IL6TNF77IL17A7RORC7IL-26 overexpressioninduces proinflammation in asthmatic patients RELAS53610CXCL8MAPK911-13T18311, 12Y185TNF12Ccl34Mpo4Mmp9Mmp24Tnf4Ccl204Cxcl244CsfFacilitates innate immune response in bronchoalveolar space of mice4JAK1P6TYK2P6IL86IL1B6CCL20IL3366DEFB4Il46Il136Il336Il17a6Ccl206Involved in human epidermal keratinocytes 6Atopic dermatitisIL812 SOCS312CXCL89IL1B9TNF9STAT19STAT39CSF29MPO9Involved in antibacterial host defenseIL10ICAM11313LigandProteinmRNARegulation of protein/gene expressionLeads to multple reactionsProteinPPost translational modificationGene/ProteinUpregulationDownregulationInduces antiapoptosis and tumor growth in murine and human TNBC cellsPIK3CAP11RELAS536Il610, 1110Il1010IL26Gene/ProteinLeads to EPHA3 mediated signalingReceptor 1Receptor 2Liver fibrosisRheumatoid arthritisJUN5, 11S73CYNUCYTranslocationCytoplasmCytoplasmJUN5, 11S73NUCY


Description

A comprehensive network map of IL-26 signaling pathway

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Chen YT, Wang CC, Cheng CP, Liu FC, Lee CH, Lee HS, Peng YJ; ''Interleukin-26 Has Synergistic Catabolic Effects with Palmitate in Human Articular Chondrocytes via the TLR4-ERK1/2-c-Jun Signaling Pathway.''; Cells, 2021 PubMed Europe PMC Scholia
  2. Dambacher J, Beigel F, Zitzmann K, De Toni EN, Goke B, Diepolder HM, Auernhammer CJ, Brand S; ''The role of the novel Th17 cytokine IL-26 in intestinal inflammation.''; Gut, 2009 PubMed Europe PMC Scholia
  3. Fujii M, Nishida A, Imaeda H, Ohno M, Nishino K, Sakai S, Inatomi O, Bamba S, Kawahara M, Shimizu T, Andoh A; ''Expression of Interleukin-26 is upregulated in inflammatory bowel disease.''; World J Gastroenterol, 2017 PubMed Europe PMC Scholia
  4. Bao A, Che KF, Bozinovski S, Ji J, Gregory JA, Georen SK, Adner M, Cardell LO, Linden A; ''Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo.''; PLoS One, 2017 PubMed Europe PMC Scholia
  5. Zhang X, Xie X, Wang Y, Li W, Lin Z; ''Interleukin-26 promotes the proliferation and activation of hepatic stellate cells to exacerbate liver fibrosis by the TGF-B1/Smad2 signaling pathway.''; Int J Clin Exp Pathol, 2019 PubMed Europe PMC Scholia
  6. Louhaichi S, Mlika M, Hamdi B, Hamzaoui K, Hamzaoui A; ''Sputum IL-26 Is Overexpressed in Severe Asthma and Induces Proinflammatory Cytokine Production and Th17 Cell Generation: A Case-Control Study of Women.''; J Asthma Allergy, 2020 PubMed Europe PMC Scholia
  7. Mayer P, Linnebacher A, Glennemeier-Marke H, Marnet N, Bergmann F, Hackert T, Klauss M, Poth T, Gaida MM; ''The Microarchitecture of Pancreatic Cancer as Measured by Diffusion-Weighted Magnetic Resonance Imaging Is Altered by T Cells with a Tumor Promoting Th17 Phenotype.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
  8. Lee KA, Kim KW, Kim BM, Won JY, Min HK, Lee DW, Kim HR, Lee SH; ''Promotion of osteoclastogenesis by IL-26 in rheumatoid arthritis.''; Arthritis Res Ther, 2019 PubMed Europe PMC Scholia
  9. Lin YH, Wang YH, Peng YJ, Liu FC, Lin GJ, Huang SH, Sytwu HK, Cheng CP; ''Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-kB Pathway.''; Cells, 2020 PubMed Europe PMC Scholia
  10. Che KF, Tengvall S, Levanen B, Silverpil E, Smith ME, Awad M, Vikstrom M, Palmberg L, Qvarfordt I, Skold M, Linden A; ''Interleukin-26 in antibacterial host defense of human lungs. Effects on neutrophil mobilization.''; Am J Respir Crit Care Med, 2014 PubMed Europe PMC Scholia
  11. Hor S, Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, Renauld JC, de Waal Malefyt R, Fickenscher H; ''The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  12. Itoh T, Hatano R, Horimoto Y, Yamada T, Song D, Otsuka H, Shirakawa Y, Mastuoka S, Iwao N, Aune TM, Dang NH, Kaneko Y, Okumura K, Morimoto C, Ohnuma K; ''IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells.''; Cell Death Dis, 2021 PubMed Europe PMC Scholia
  13. Kamijo H, Miyagaki T, Hayashi Y, Akatsuka T, Watanabe-Otobe S, Oka T, Shishido-Takahashi N, Suga H, Sugaya M, Sato S; ''Increased IL-26 Expression Promotes T Helper Type 17- and T Helper Type 2-Associated Cytokine Production by Keratinocytes in Atopic Dermatitis.''; J Invest Dermatol, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129744view01:55, 22 May 2024EweitzModified title
126468view05:51, 2 May 2023EgonwNot mim-conversions
126466view04:46, 2 May 2023EgonwBinding instead?
126456view20:24, 30 April 2023AlexanderPicoremoved more data-coded color
126455view20:21, 30 April 2023AlexanderPicoremoved data-coded color; replaced datanodes in legend
126454view20:05, 30 April 2023AlexanderPicofixed citations
126072view22:35, 31 March 2023KhanspersOntology Term : 'interleukin-6 signaling pathway' added !
126071view22:35, 31 March 2023KhanspersOntology Term : 'signaling pathway' added !
126019view07:49, 27 March 2023Rex D A B
126018view07:48, 27 March 2023Rex D A B
126017view07:43, 27 March 2023Rex D A B
126016view07:25, 27 March 2023Rex D A B
126015view05:31, 27 March 2023Rex D A B
126014view05:25, 27 March 2023Rex D A B
126013view05:19, 27 March 2023Rex D A B
126010view10:29, 26 March 2023EgonwUpdated the UniProt data sources
126009view13:48, 25 March 2023Rex D A B
126008view13:41, 25 March 2023Rex D A B
126007view11:39, 25 March 2023Rex D A BMolecule rearrangement
126006view11:01, 25 March 2023Rex D A BPathway arrangement
126003view07:32, 25 March 2023Rex D A BNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
NFATC1GeneProduct4772 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
ACTA2GeneProduct59 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
ATP6V0D2GeneProduct245972 (Entrez Gene)
BAXGeneProduct581 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CCL20GeneProduct6364 (Entrez Gene)
COX2ProteinP00403 (Uniprot-TrEMBL)
CSF2GeneProduct1437 (Entrez Gene)
CTSKGeneProduct1513 (Entrez Gene)
CXCL8GeneProduct3576 (Entrez Gene)
Ccl20GeneProduct20297 (Entrez Gene)
Ccl3ProteinP10855 (Uniprot-TrEMBL)
Cd80GeneProduct12519 (Entrez Gene)
CsfGeneProduct12977 (Entrez Gene)
Cxcl2GeneProduct20310 (Entrez Gene)
DCSTAMPGeneProduct81501 (Entrez Gene)
DDIT3 ProteinP35638 (Uniprot-TrEMBL)
DEFB4GeneProduct1673 (Entrez Gene)
EPHA3 ProteinP29320 (Uniprot-TrEMBL)
Gene/ProteinRna
ICAM1GeneProduct3383 (Entrez Gene)
IL10GeneProduct3586 (Entrez Gene)
IL10R2ProteinQ08334 (Uniprot-TrEMBL)
IL17AGeneProduct3605 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL1BProteinP01584 (Uniprot-TrEMBL)
IL20R1ProteinQ9UHF4 (Uniprot-TrEMBL)
IL26ProteinQ9NPH9 (Uniprot-TrEMBL)
IL33GeneProduct90865 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL6ProteinP05231 (Uniprot-TrEMBL)
IL8GeneProduct3576 (Entrez Gene)
IL8ProteinP10145 (Uniprot-TrEMBL)
Il10Protein16153 (Entrez Gene)
Il13GeneProduct16163 (Entrez Gene)
Il17aGeneProduct16171 (Entrez Gene)
Il33GeneProduct77125 (Entrez Gene)
Il4GeneProduct16189 (Entrez Gene)
Il6Protein16193 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
LigandProtein
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MMP1ProteinP03956 (Uniprot-TrEMBL)
MMP9GeneProduct4318 (Entrez Gene)
MPOProteinP05164 (Uniprot-TrEMBL)
Mmp2ProteinP33434 (Uniprot-TrEMBL)
Mmp9ProteinP41245 (Uniprot-TrEMBL)
MpoProteinP11247 (Uniprot-TrEMBL)
NFKBIAProtein4792 (Entrez Gene)
Nos2GeneProduct18126 (Entrez Gene)
OCSTAMPGeneProduct74614 (Entrez Gene)
PIK3CAProtein5290 (Entrez Gene)
ProteinProtein
RELAProtein5970 (Entrez Gene)
RELAProteinQ04206 (Uniprot-TrEMBL)
RORCGeneProduct6097 (Entrez Gene)
Receptor 1w (WikiPathways)
Receptor 2ProteinQ9UHF4 (Uniprot-TrEMBL)
SMAD2ProteinQ15796 (Uniprot-TrEMBL)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TGFB1ProteinP01137 (Uniprot-TrEMBL)
TNFGeneProduct7124 (Entrez Gene)
TNFProteinP01375 (Uniprot-TrEMBL)
TNFSF11 GeneProduct8600 (Entrez Gene)
TRAPGeneProduct100187907 (Entrez Gene)
TYK2Protein7297 (Entrez Gene)
TnfGeneProduct21926 (Entrez Gene)
cleaved CASP3GeneProduct836 (Entrez Gene)
mRNARna

Annotated Interactions

No annotated interactions

Personal tools