Immune adverse outcome pathways (Homo sapiens)

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T-cell receptor signaling pathwayRecognition of AECCytokine release syndromeEndothelial cell activationPro-inflammatory mediatorsLeukocyte recruitmentSystemic inflammationType II interferon signaling TNF-alpha signaling pathwayIL-2 signaling pathwayCytokine storm syndromeOverview of proinflammatory and profibrotic mediators Macrophage markersIncreased, secretion of proinflammatory mediatorsOverview of proinflammatory and profibrotic mediators Binding to ACE2Soluble ACE2-mediated cell entry of SARS-CoV-2Increase, Cell deathApoptosis modulation and signalingApoptosisIncreased, recruitment of inflammatory cells HyperinflammationCytokine storm syndromeIncreased SARS-CoV-2 productionInterferon-I antiviral response, antagonized by SARS-CoV-2SARS-CoV-2 cell entrySARS coronavirus and innate immunity


Description

AOP of immune activation

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
127661view19:33, 14 November 2023AlexanderPicoModified title
127660view19:33, 14 November 2023AlexanderPicoModified title
126865view09:11, 28 June 2023Marvin M2Ontology Term : 'inflammatory response pathway' added !
126482view10:09, 8 May 2023Marvin M2added KE IDs
126481view10:07, 8 May 2023Marvin M2Extended with AOP492
126480view09:49, 8 May 2023Marvin M2New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Hyperinflammation1868 (AOP-Wiki KE)
Apoptosis modulation and signalingPathwayWP1772 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
Binding to ACE21739 (AOP-Wiki KE)
Cytokine release syndrome
Cytokine storm syndromePathwayWP5257 (WikiPathways)
Endothelial cell activation
IL-2 signaling pathwayPathwayWP49 (WikiPathways)
Increase, Cell death1825 (AOP-Wiki KE)
Increased SARS-CoV-2 production1847 (AOP-Wiki KE)
Increased, recruitment of inflammatory cells1497 (AOP-Wiki KE)
Increased, secretion of proinflammatory mediators1496 (AOP-Wiki KE)
Interferon-I antiviral response, antagonized by SARS-CoV-21901 (AOP-Wiki KE)
Leukocyte recruitment
Macrophage markersPathwayWP4146 (WikiPathways)
Overview of proinflammatory and profibrotic mediators PathwayWP5095 (WikiPathways)
Pro-inflammatory mediators
Recognition of AEC
SARS coronavirus and innate immunityPathwayWP4912 (WikiPathways)
SARS-CoV-2 cell entry1738 (AOP-Wiki KE)
Soluble ACE2-mediated cell entry of SARS-CoV-2PathwayWP5076 (WikiPathways)
Systemic inflammation
T-cell receptor signaling pathwayPathwayWP69 (WikiPathways)
TNF-alpha signaling pathwayPathwayWP231 (WikiPathways)
Type II interferon signaling PathwayWP619 (WikiPathways)

Annotated Interactions

No annotated interactions

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