TAR syndrome (Homo sapiens)

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1316, 17, 2829, 32629, 32521, 22192, 2320, 261, 1224718274195113029, 321510, 16, 17, 282, 239, 16, 17, 28, 312, 23152, 23729, 32613, 1829, 3210, 142, 23382578332, 231, 12718Receptor for collagenStabilizingOn CD8+ T-cellsSubstratesSensesRequired for pre-mRNA as component of the splicosomeNF-κBCostimulatory signals toactivated/memory CD8+ T-cellsEJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAMembrane protrusion and elongationon the peroxisomal surfaceIn activated NK cellsFormation of proapoptotic isoformsIn response to sensing of non-self RNAT-cell exhaustionVoltage dependent anion channel required foracidification and functions of the Golgi apparatusthat may function in counter-ion conductance HydrolysisIn HSCsPersistentOn activated CD4+ T-cellschr1:145,394,955AngiogenesisDuring viral infectionProgressivelyFunction unknownIn immune privileged sitesMaintaining normal cholesterol levelsLys-48 and/or Lys-63 linkedReceptor for classical andnon-classical MHCI moleculesMulti drug resistanceCluster proteins, modulate theirtrafficking and activityAntigenBidirectional signallingDNARNA polymeraseIn activated T-cellsSplicing modulationType I IFNsDuring bacterial infectionNK cell cytotoxic activityNucleoside diphosphate derivativesTraps EJC onto spliced mRNAOn NK cellsIn the brush border of the proximal tubule of the kidneyMost probably non-functionalE2 dependentTumour cell growthRNACD28 costimulatory signalingnon-self dsDNAPOLR3FSUMO1LIX1LITGA10HJVBMPCD160TXNBCL2L13EIF4A3SubstrateCOPS5FLT3IFNGRABL3PYM1RNF115HLA-AFURINGPR89AGNRHR2PDZK1IP1STAT3JAK/STAT pathwayTNFRSF14CDKN1BPeroxisomal proliferationPDZK1CCAR2PEX11BPeroxisome divisionNUDT17DNAHLA-GMaturation of NK cellsNonsense mediated decay pathwayPDZK1RIG-I pathwayABCC2EGFRTCR signallingmTORC1PI3KUBE2IRBM8AMETCFTRProduction of anti-microbial proteinsand inflammatory cytokinesTXNIPANKRD34ANHERF1Viral peptidePIAS3CD247Lymphocyte developmentCollagennon-self RNAHLA-CCXCR4MAGOHDNASIRT1GnRH-IIPOLR3GLDNM1LCD3Signalling pathwaysTBPHepcidinBRF1MTA1Proteasomal degradation of DDIT4ANKRD35Iron homeostasisLCKPOLR3CSteroid hormone signalling pathwayPOLR3CPOLR3GRNAZFHX3SCARB1SLC26A6RBM8AMTA1SCCAR2SZFHX3SubstrateUCXCR4METFLT3EGFRUUUUSignalling pathwaysDuring viral infectionHLA-AIn immune privileged sitesFunction unknownFunction unknownCatalysisBindingUbiquitinatedLEGENDInhibitionSumoylatedConversionStimulationUS


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Bibliography

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History

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CompareRevisionActionTimeUserComment
134655view09:21, 24 July 2024EgonwCompleted a datasource
134452view00:02, 22 July 2024EweitzOntology Term : 'disease of mental health' added !
127046view09:38, 26 July 2023FehrhartOntology Term : 'Disease' added !
127045view09:38, 26 July 2023FehrhartOntology Term : 'disease pathway' added !
127044view09:37, 26 July 2023FehrhartModified description
127043view09:30, 26 July 2023Fehrhartcorrections and updates (done)
127042view07:47, 26 July 2023Fehrhartupdate in progress
127041view06:54, 26 July 2023Fehrhartupdate in progress
127029view13:11, 24 July 2023Fehrhartupdate
127028view12:36, 24 July 2023Fehrhartupgrade
127027view12:00, 24 July 2023Fehrhartupgrade
126901view14:14, 30 June 2023JmillanacostaChanged legend interactions and nodes to graphical objects
126849view09:37, 27 June 2023Ewoud
126578view15:20, 4 June 2023Ewoudfiller
126517view15:21, 23 May 2023EwoudNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCC2GeneProductENSG00000023839 (Ensembl)
ANKRD34AGeneProductENSG00000181039 (Ensembl)
ANKRD35GeneProductENSG00000198483 (Ensembl)
BCL2L13GeneProductENSG00000099968 (Ensembl)
BMPMetaboliteCHEBI:60815 (ChEBI)
BRF1GeneProductENSG00000185024 (Ensembl)
CCAR2GeneProductENSG00000158941 (Ensembl)
CD160GeneProductENSG00000117281 (Ensembl)
CD247GeneProductENSG00000198821 (Ensembl)
CD28 costimulatory signalingPathway
CD3GeneProductENSG00000167286 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CFTRGeneProductENSG00000001626 (Ensembl)
COPS5GeneProductENSG00000121022 (Ensembl)
CXCR4GeneProductENSG00000121966 (Ensembl)
CollagenMetaboliteCHEBI:3815 (ChEBI)
DNAGeneProduct
DNM1LGeneProductENSG00000087470 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
EIF4A3GeneProductENSG00000141543 (Ensembl)
FLT3GeneProductENSG00000122025 (Ensembl)
FURINGeneProductENSG00000140564 (Ensembl)
GNRHR2GeneProductENSG00000211451 (Ensembl)
GPR89AGeneProductENSG00000117262 (Ensembl)
GnRH-IIMetaboliteCHEBI:80298 (ChEBI)
HJVGeneProductENSG00000168509 (Ensembl) HAEMOJUVELIN, HEMOJUVELIN, HFE2, HFE2A
HLA-AGeneProductENSG00000206503 (Ensembl)
HLA-CGeneProductENSG00000204525 (Ensembl)
HLA-GGeneProductENSG00000204632 (Ensembl)
HepcidinMetaboliteHMDB0259694 (HMDB)
IFNGGeneProductENSG00000111537 (Ensembl)
ITGA10GeneProductENSG00000143127 (Ensembl)
Iron homeostasisPathway
JAK/STAT pathwayPathwaymap04630 (KEGG Pathway)
LCKGeneProductENSG00000182866 (Ensembl)
LIX1LGeneProductENSG00000152022 (Ensembl)
Lymphocyte developmentPathway
MAGOHGeneProductENSG00000162385 (Ensembl)
METGeneProductENSG00000105976 (Ensembl)
MTA1GeneProductENSG00000182979 (Ensembl)
Maturation of NK cellsPathway
NHERF1GeneProductENSG00000109062 (Ensembl)
NUDT17GeneProductENSG00000186364 (Ensembl)
Nonsense mediated decay pathwayPathway
PDZK1GeneProductENSG00000174827 (Ensembl)
PDZK1IP1GeneProductENSG00000162366 (Ensembl)
PEX11BGeneProductENSG00000131779 (Ensembl)
PI3KMetaboliteCHEBI:89296 (ChEBI)
PIAS3GeneProductENSG00000131788 (Ensembl)
POLR3CGeneProductENSG00000186141 (Ensembl)
POLR3FGeneProductENSG00000132664 (Ensembl)
POLR3GGeneProductENSG00000113356 (Ensembl)
POLR3GLGeneProductENSG00000121851 (Ensembl)
PYM1GeneProductENSG00000170473 (Ensembl)
Peroxisomal proliferationPathway
Peroxisome divisionPathway
Production of anti-microbial proteins and inflammatory cytokinesPathway
Proteasomal degradation of DDIT4Pathway
RABL3GeneProductENSG00000144840 (Ensembl)
RBM8AGeneProductENSG00000131795 (Ensembl)
RIG-I pathwayPathway
RNARna
RNF115GeneProductENSG00000121848 (Ensembl)
SCARB1GeneProductENSG00000073060 (Ensembl)
SIRT1GeneProductENSG00000096717 (Ensembl)
SLC26A6GeneProductENSG00000225697 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
SUMO1GeneProductENSG00000116030 (Ensembl)
Signalling pathwaysPathway
Steroid hormone signalling pathwayPathway
SubstrateMetabolite
TBPMetaboliteCHEBI:35019 (ChEBI)
TCR signallingPathway
TNFRSF14GeneProductENSG00000157873 (Ensembl)
TXNGeneProductENSG00000136810 (Ensembl)
TXNIPGeneProductENSG00000117289 (Ensembl)
Tumour cell growthPathway
UBE2IGeneProductENSG00000103275 (Ensembl)
Viral peptideMetabolite
ZFHX3GeneProductENSG00000140836 (Ensembl)
mTORC1ProteinF5H479 (Uniprot-TrEMBL)
non-self RNARna
non-self dsDNAGeneProduct

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5362"
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