MFAP5-mediated ovarian cancer cell motility and invasiveness (Homo sapiens)

Revision as of 22:11, 9 August 2023 by Khanspers (Talk | contribs)

Description

A graphical summary of the molecular signaling events involved in MFAP5-mediated ovarian cancer cell motility and invasiveness.

Based on figure 6c in Leung et al. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

View approved pathways at the new wikipathways.org.

Review changes for Approved

Community: CPTAC

Pathway Ontology : inborn error of metabolism pathway heme biosynthetic pathway disease pathway porphyria pathway hepatic porphyria pathway pathway acute intermittent porphyria pathway erythropoietic porphyria pathway

Disease : erythropoietic protoporphyria cutaneous porphyria porphyria cutanea tarda inherited metabolic disorder hepatoerythropoietic porphyria acute intermittent porphyria acute porphyria porphyria sideroblastic anemia 1

Cell Type : hepatocyte

Leung CS, Yeung TL, Yip KP, Pradeep S, Balasubramanian L, Liu J, Wong KK, Mangala LS, Armaiz-Pena GN, Lopez-Berestein G, Sood AK, Birrer MJ, Mok SC; ''Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.''; Nat Commun, 2014 PubMed Europe PMC Scholia
Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
137085 Approved	view	22:01, 27 February 2025	Khanspers	Modified description
127230	view	20:08, 25 August 2023	Khanspers	added lit ref and updated description
127188	view	22:11, 9 August 2023	Khanspers	updated phosphosites
126996	view	19:27, 14 July 2023	Khanspers	clarify interactions, updated labels, some reactions
120029 CPTAC	view	23:19, 15 October 2021	Khanspers	updated phosphosites
108104	view	10:16, 29 November 2019	Fehrhart	Ontology Term : 'cancer pathway' added !
106638	view	21:02, 12 September 2019	Khanspers	Modified description
106199	view	12:09, 16 August 2019	MaintBot	HMDB identifier normalization
105459	view	05:09, 8 August 2019	Khanspers	Modified description
103743	view	20:48, 2 April 2019	Khanspers	Modified description
103742	view	20:47, 2 April 2019	Khanspers	Modified description
97674	view	11:23, 1 June 2018	AMTan	Ontology Term : 'ovarian cancer' added !
94277	view	18:09, 30 August 2017	Khanspers	phosphorylations, updated for clarity
87836	view	11:46, 25 July 2016	Elisa	Ontology Term : 'disease of cellular proliferation' added !
87835	view	11:46, 25 July 2016	Elisa	Ontology Term : 'disease pathway' added !
81279	view	04:54, 14 August 2015	Khanspers	Modified description
81278	view	04:52, 14 August 2015	Khanspers	New pathway

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Name	Type	Database reference
CREB1	GeneProduct	ENSG00000118260 (Ensembl)
Ca2+	Metabolite	HMDB0000464 (HMDB)
DAG	Metabolite	HMDB0007098 (HMDB)
ERK1	GeneProduct	ENSG00000102882 (Ensembl)
ERK2	GeneProduct	ENSG00000100030 (Ensembl)
FAK	GeneProduct	ENSG00000169398 (Ensembl)
IP3	Metabolite	85166-31-0 (CAS)
ITGAV	GeneProduct	ENSG00000138448 (Ensembl)
ITGB3	GeneProduct	ENSG00000259207 (Ensembl)
ITPR3	GeneProduct	ENSG00000096433 (Ensembl)
JUN	GeneProduct	ENSG00000177606 (Ensembl)
MFAP5	GeneProduct	ENSG00000197614 (Ensembl)
PIP2	Metabolite	245126-95-8 (CAS)
PLCG1	GeneProduct	ENSG00000124181 (Ensembl)
PRKCQ	GeneProduct	ENSG00000065675 (Ensembl)
RYR3	GeneProduct	ENSG00000198838 (Ensembl)
TNNC1	GeneProduct	ENSG00000114854 (Ensembl)
Troponin C	GeneProduct	ENSG00000114854 (Ensembl)

No annotated interactions