IDO metabolic pathway (Homo sapiens)
From WikiPathways
Description
Overview of the IDO metabolic pathway. Approximately 95% of L-tryptophan (Trp) is catabolized into kynurenine (Kyn) through three rate-limiting enzymes: tryptophan 2,3-dioxygenase (TDO) in the liver and indoleamine 2, 3-dioxygenase 1/2 (IDO1/2) in peripheral tissues. Kyn is converted to 3-hydroxykynurenine (3-HK) by kynurenine 3-monooxygenase (KMO), to anthranilic acid (AA) by kynureninase (KYNase), or to kynurenic acid (KYNA) by kynurenine aminotransferase (KAT). Next, catalyzed by KYNase, 3-HK is converted to 3-hydroxyanthranilic acid (3-HAA), which is further converted to quinolinic acid (QA), picolinic acid, nicotinamide adenine dinucleotide (NAD+), and other molecules.
PFOCR entry: https://pfocr.wikipathways.org/figures/PMC6090955__13045_2018_644_Fig1_HTML.html
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Ontology Terms
Saving...Bibliography
- Liu M, Wang X, Wang L, Ma X, Gong Z, Zhang S, Li Y; ''Targeting the IDO1 pathway in cancer: from bench to bedside.''; J Hematol Oncol, 2018 PubMed Europe PMC Scholia
- Lawler NG, Gray N, Kimhofer T, Boughton B, Gay M, Yang R, Morillon AC, Chin ST, Ryan M, Begum S, Bong SH, Coudert JD, Edgar D, Raby E, Pettersson S, Richards T, Holmes E, Whiley L, Nicholson JK; ''Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses.''; J Proteome Res, 2021 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| 3-Hydroxyanthranilic Acid | Metabolite | CHEBI:15793 (ChEBI)  | |
| 3-Hydroxykynurenine | Metabolite | CHEBI:1547 (ChEBI) | |
| AADAT | Protein | Q8N5Z0 (Uniprot-TrEMBL) | |
| AATM | Protein | P00505 (Uniprot-TrEMBL) | |
| Anthranilic Acid | Metabolite | CHEBI:30754 (ChEBI) | |
| IDO1 | Protein | P14902 (Uniprot-TrEMBL) | |
| IDO2 | Protein | Q6ZQW0 (Uniprot-TrEMBL) | |
| IFNG | Protein | P01579 (Uniprot-TrEMBL) | |
| INFA | Protein | ||
| KAT1 | Protein | Q16773 (Uniprot-TrEMBL) | |
| KAT3 | Protein | Q6YP21 (Uniprot-TrEMBL) | |
| KMO | Protein | O15229 (Uniprot-TrEMBL) | |
| KYNU | Protein | Q16719 (Uniprot-TrEMBL) | |
| Kynurenic Acid | Metabolite | CHEBI:18344 (ChEBI) | |
| Kynurenine | Metabolite | CHEBI:57959 (ChEBI) | |
| L-Tryptophan | Metabolite | CHEBI:16828 (ChEBI) | |
| NAD+ | Metabolite | CHEBI:13389 (ChEBI) | |
| Neopterin | Metabolite | ||
| Picolinic Acid | Metabolite | CHEBI:28747 (ChEBI) | |
| Quinolinic Acid | Metabolite | CHEBI:16675 (ChEBI) | |
| T23O | Protein | P48775 (Uniprot-TrEMBL) | |
| TNFA | Protein | P01375 (Uniprot-TrEMBL) |
Annotated Interactions
No annotated interactions
