lncRNA in canonical Wnt signaling and colorectal cancer (Homo sapiens)

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ScaffoldAPC21, 2NucleusLegendCytoplasmTranscriptional ActivationActivating mutationWnt target genesProliferationMigration, invasionStem cell maintenanceTCF7L1FZD9CSNK1A1FZD1DVL3FZD5CCND3FZD8RUVBL1WNT2BWNT10BJUNFOSL1H2AFY2MAP3K7AXIN1CDK6CSNK2A1WNT4HNRNPKLRP6FZD6PLAUWNT5BFZD10APCMIR34ACSNK1A1LMAPK SignalingWNT7ARBM5-AS1CHD8WNT10ADVL2EZH2CSNK1ECCALGSK3BTCF7TCF3RYKWNT7BCTNNB1DVL1lnc34AWNT2FZD7WNT3ACell cycle progressionFZD2ATF3WNT6CCND1MYCWNT5ALEF1WNT16TFAP2AWNT16WNT3TCF7L2WNT11ROR1FZD4CSNK2A3WNT1CSNK2A2CCND2FRAT1CSNK2BCDK8FZD3KREM1LRP526S Proteasome DegradationPPPPPPPROR2CTNNB1DKK1DKK2DKK4SOSTSERPINF1FRAT2CTNNB1SFRP1SFRP2SFRP4SFRP5NOTUMCER1WIF1PORCNNKD1NKD2CXXC4SENP2NLKCTNNBIP1SOX17CTBP1CTBP2MIR16-2MIR16-1MYUH19NKD1HNRNPUH19H19ASBELInactivating mutationlncRNAmiRNAAXIN2


Description

Long non-coding RNAs (lncRNAs) have emerged as significant players in colorectal cancer pathogenesis. This pathway represents a review of long non-coding RNA (LncRNA) involvement in canonical Wnt signaling as it relates to colorectal cancer. The pathway is adapted from Shen et al . Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Shen P, Pichler M, Chen M, Calin GA, Ling H; ''To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer.''; Int J Mol Sci, 2017 PubMed Europe PMC Scholia
  2. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127462view01:12, 7 October 2023Khanspersupdated phospho sites
127400view21:41, 29 September 2023Khanspersupdated phospho sites
127239view00:16, 26 August 2023Khanspersadded lit ref and updated description
123417view06:11, 26 July 2022EgonwMade three pathways clickable
117770view13:31, 22 May 2021EweitzModified title
108136view10:32, 29 November 2019FehrhartOntology Term : 'colorectal cancer' added !
108135view10:31, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106508view20:40, 5 September 2019KhanspersModified description
105487view05:44, 8 August 2019KhanspersModified description
105471view05:18, 8 August 2019KhanspersModified description
97136view21:42, 30 April 2018Khanspersconnected missing interaction
96917view15:43, 19 April 2018Khanspersfixed broken interaction
96905view19:14, 18 April 2018KhanspersModified description
96904view18:52, 18 April 2018Khanspersfixed broken interaction
96890view05:35, 18 April 2018KhanspersModified description
96889view05:34, 18 April 2018Khansperschanged scaffold location
96888view05:33, 18 April 2018KhanspersOntology Term : 'disease pathway' added !
96887view05:33, 18 April 2018KhanspersOntology Term : 'Wnt signaling, canonical pathway' added !
96886view05:32, 18 April 2018KhanspersOntology Term : 'colorectal cancer pathway' added !
96885view05:31, 18 April 2018KhanspersModified title
96884view05:31, 18 April 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
26S Proteasome DegradationPathwayWP183 (WikiPathways)
APC2GeneProductENSG00000115266 (Ensembl)
APCGeneProduct324 (Entrez Gene)
ASBELGeneProduct
ATF3GeneProductENSG00000162772 (Ensembl)
AXIN1GeneProduct8312 (Entrez Gene)
AXIN2GeneProductENSG00000168646 (Ensembl)
CCALGeneProduct
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CDK6GeneProductENSG00000105810 (Ensembl)
CDK8GeneProductENSG00000132964 (Ensembl)
CER1GeneProductENSG00000147869 (Ensembl)
CHD8GeneProductENSG00000100888 (Ensembl)
CSNK1A1GeneProductENSG00000113712 (Ensembl)
CSNK1A1LGeneProductENSG00000180138 (Ensembl)
CSNK1EGeneProduct1454 (Entrez Gene)
CSNK2A1GeneProductENSG00000101266 (Ensembl)
CSNK2A2GeneProductENSG00000070770 (Ensembl)
CSNK2A3GeneProductENSG00000254598 (Ensembl)
CSNK2BGeneProductENSG00000204435 (Ensembl)
CTBP1GeneProductENSG00000159692 (Ensembl)
CTBP2GeneProductENSG00000175029 (Ensembl)
CTNNB1GeneProduct1499 (Entrez Gene)
CTNNBIP1GeneProductENSG00000178585 (Ensembl)
CXXC4GeneProductENSG00000168772 (Ensembl)
Cell cycle progressionPathwayWP179 (WikiPathways)
DKK1GeneProductENSG00000107984 (Ensembl)
DKK2GeneProductENSG00000155011 (Ensembl)
DKK4GeneProductENSG00000104371 (Ensembl)
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
EZH2GeneProductENSG00000106462 (Ensembl)
FOSL1GeneProduct8061 (Entrez Gene)
FRAT1GeneProduct10023 (Entrez Gene)
FRAT2GeneProductENSG00000181274 (Ensembl)
FZD10GeneProduct11211 (Entrez Gene)
FZD1GeneProduct8321 (Entrez Gene)
FZD2GeneProduct2535 (Entrez Gene)
FZD3GeneProduct7976 (Entrez Gene)
FZD4GeneProduct6424 (Entrez Gene)
FZD5GeneProduct7855 (Entrez Gene)
FZD6GeneProduct8323 (Entrez Gene)
FZD7GeneProduct8324 (Entrez Gene)
FZD8GeneProduct8325 (Entrez Gene)
FZD9GeneProduct8326 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene) MOUSE:KG38 MOUSE
H19GeneProductENSG00000130600 (Ensembl)
H2AFY2GeneProductENSG00000099284 (Ensembl)
HNRNPKGeneProductENSG00000165119 (Ensembl)
HNRNPUGeneProductENSG00000153187 (Ensembl)
JUNGeneProduct3725 (Entrez Gene)
KREM1GeneProduct83999 (Entrez Gene)
LEF1GeneProductENSG00000138795 (Ensembl)
LRP5GeneProduct4041 (Entrez Gene)
LRP6GeneProduct4040 (Entrez Gene)
MAP3K7GeneProductENSG00000135341 (Ensembl)
MAPK SignalingPathwayWP382 (WikiPathways)
MIR16-1GeneProductENSG00000208006 (Ensembl)
MIR16-2GeneProductENSG00000198987 (Ensembl)
MIR34AGeneProductENSG00000228526 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
MYUGeneProduct
NKD1GeneProductENSG00000140807 (Ensembl)
NKD2GeneProductENSG00000145506 (Ensembl)
NLKGeneProductENSG00000087095 (Ensembl)
NOTUMGeneProductENSG00000185269 (Ensembl)
PLAUGeneProduct5328 (Entrez Gene)
PORCNGeneProductENSG00000102312 (Ensembl)
RBM5-AS1GeneProduct
ROR1GeneProduct4919 (Entrez Gene)
ROR2GeneProduct4920 (Entrez Gene)
RUVBL1GeneProductENSG00000175792 (Ensembl)
RYKGeneProduct6259 (Entrez Gene)
SENP2GeneProductENSG00000163904 (Ensembl)
SERPINF1GeneProductENSG00000132386 (Ensembl)
SFRP1GeneProductENSG00000104332 (Ensembl)
SFRP2GeneProductENSG00000145423 (Ensembl)
SFRP4GeneProductENSG00000106483 (Ensembl)
SFRP5GeneProductENSG00000120057 (Ensembl)
SOSTGeneProductENSG00000167941 (Ensembl)
SOX17GeneProductENSG00000164736 (Ensembl)
TCF3GeneProductENSG00000071564 (Ensembl)
TCF7GeneProductENSG00000081059 (Ensembl)
TCF7L1GeneProductENSG00000152284 (Ensembl)
TCF7L2GeneProductENSG00000148737 (Ensembl)
TFAP2AGeneProductENSG00000137203 (Ensembl)
WIF1GeneProductENSG00000156076 (Ensembl)
WNT10AGeneProduct80326 (Entrez Gene)
WNT10BGeneProduct7480 (Entrez Gene)
WNT11GeneProduct7481 (Entrez Gene)
WNT16GeneProduct51384 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT2GeneProduct7472 (Entrez Gene)
WNT2BGeneProduct7482 (Entrez Gene)
WNT3GeneProduct7473 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT4GeneProduct54361 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
WNT5BGeneProduct81029 (Entrez Gene)
WNT6GeneProduct7475 (Entrez Gene)
WNT7AGeneProduct7476 (Entrez Gene)
WNT7BGeneProduct7477 (Entrez Gene)
lnc34AGeneProduct

Annotated Interactions

No annotated interactions

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