PI3K-Akt signaling (Homo sapiens)

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Revision as of 00:26, 26 August 2023 by Khanspers (Talk | contribs)

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Description

The PI3K-Akt signaling pathway can be activated by many types of cellular stimuli or toxic insults and regulates many fundamental cellular functions. Activated PI3K phosphorylates AKT, thereby activating it. Once active, Akt controls a number of downstream cellular processes, including apoptosis, protein synthesis, metabolism, and cell cycle, by phosphorylating a range of substrates. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

Bibliography

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Blume-Jensen P, Hunter T; ''Oncogenic kinase signalling.''; Nature, 2001 PubMed Europe PMC Scholia
Song G, Ouyang G, Bao S; ''The activation of Akt/PKB signaling pathway and cell survival.''; J Cell Mol Med, 2005 PubMed Europe PMC Scholia
Okkenhaug K, Vanhaesebroeck B; ''PI3K in lymphocyte development, differentiation and activation.''; Nat Rev Immunol, 2003 PubMed Europe PMC Scholia
Noguchi M, Ropars V, Roumestand C, Suizu F; ''Proto-oncogene TCL1: more than just a coactivator for Akt.''; FASEB J, 2007 PubMed Europe PMC Scholia
Duronio V; ''The life of a cell: apoptosis regulation by the PI3K/PKB pathway.''; Biochem J, 2008 PubMed Europe PMC Scholia
Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR; ''Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.''; Biochem J, 1998 PubMed Europe PMC Scholia
Hers I, Vincent EE, Tavaré JM; ''Akt signalling in health and disease.''; Cell Signal, 2011 PubMed Europe PMC Scholia
Engelman JA, Luo J, Cantley LC; ''The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.''; Nat Rev Genet, 2006 PubMed Europe PMC Scholia
Richardson CJ, Schalm SS, Blenis J; ''PI3-kinase and TOR: PIKTORing cell growth.''; Semin Cell Dev Biol, 2004 PubMed Europe PMC Scholia
West KA, Castillo SS, Dennis PA; ''Activation of the PI3K/Akt pathway and chemotherapeutic resistance.''; Drug Resist Updat, 2002 PubMed Europe PMC Scholia
Koyasu S; ''The role of PI3K in immune cells.''; Nat Immunol, 2003 PubMed Europe PMC Scholia
Skaper SD; ''The neurotrophin family of neurotrophic factors: an overview.''; Methods Mol Biol, 2012 PubMed Europe PMC Scholia
Georgescu MM; ''PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.''; Genes Cancer, 2010 PubMed Europe PMC Scholia
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M; ''Regulation of Raf-Akt Cross-talk.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
Lemmon MA, Schlessinger J; ''Cell signaling by receptor tyrosine kinases.''; Cell, 2010 PubMed Europe PMC Scholia
Zhang X, Tang N, Hadden TJ, Rishi AK; ''Akt, FoxO and regulation of apoptosis.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
Wymann MP, Pirola L; ''Structure and function of phosphoinositide 3-kinases.''; Biochim Biophys Acta, 1998 PubMed Europe PMC Scholia
Kikani CK, Dong LQ, Liu F; ''"New"-clear functions of PDK1: beyond a master kinase in the cytosol?''; J Cell Biochem, 2005 PubMed Europe PMC Scholia
Kim D, Chung J; ''Akt: versatile mediator of cell survival and beyond.''; J Biochem Mol Biol, 2002 PubMed Europe PMC Scholia
Osaki M, Oshimura M, Ito H; ''PI3K-Akt pathway: its functions and alterations in human cancer.''; Apoptosis, 2004 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
134839	view	16:53, 27 July 2024	Eweitz	"CytokineR" -> "Cytokine receptor"
129658	view	00:38, 22 May 2024	Eweitz	Modified title
128769	view	23:08, 21 February 2024	Eweitz	Upgrade disease node
128035	view	17:28, 21 January 2024	Eweitz	Fix typos, tailor node dimensions, standardize case
127493	view	18:34, 11 October 2023	Khanspers	updated phosphosites, updated line type, corrected node height
127444	view	23:39, 2 October 2023	Khanspers	updated phosphosites
127442	view	23:24, 2 October 2023	Khanspers	updated AKT phospho sites
127243	view	00:26, 26 August 2023	Khanspers	added lit ref and updated description
122580	view	16:46, 17 April 2022	Egonw	Made multiple pathways clickable
116400	view	00:03, 7 May 2021	Eweitz	Modified title
112040	view	20:02, 16 September 2020	Khanspers	updated phosphosites
106781	view	13:26, 17 September 2019	MaintBot	HMDB identifier normalization
106516	view	21:14, 5 September 2019	Khanspers	Modified description
105775	view	19:41, 15 August 2019	Khanspers	Modified description
96453	view	11:31, 15 March 2018	Egonw	Replaced a secondary ChEBI identifier with a primary identifier.
95701	view	19:55, 18 January 2018	Khanspers	Ontology Term : 'cell cycle pathway' added !
95695	view	19:49, 18 January 2018	Khanspers	Modified description
95694	view	19:48, 18 January 2018	Khanspers	Modified description
95693	view	19:48, 18 January 2018	Khanspers	Modified description
95684	view	18:19, 18 January 2018	Ariutta	Ontology Term : 'cancer pathway' added !
95683	view	18:18, 18 January 2018	Ariutta	Ontology Term : 'cancer' added !
95682	view	18:08, 18 January 2018	Ariutta	Modified description
95163	view	00:42, 18 November 2017	Khanspers	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
AKT1	GeneProduct	ENSG00000142208 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11651
AKT2	GeneProduct	ENSG00000105221 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11652
AKT3	GeneProduct	ENSG00000117020 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23797
AMP	Metabolite	CHEBI:16027 (ChEBI)
ANGPT1	GeneProduct	ENSG00000154188 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11600
ANGPT2	GeneProduct	ENSG00000091879 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11601
ANGPT4	GeneProduct	ENSG00000101280 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11602
ATF2	GeneProduct	ENSG00000115966 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11909
ATF4	GeneProduct	ENSG00000128272 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11911
ATF6B	GeneProduct	ENSG00000213676 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12915
Angiogenesis	Pathway	WP1539 (WikiPathways)
Apoptosis	Pathway	WP254 (WikiPathways)
B Cell Receptor Signaling Pathway	Pathway	WP23 (WikiPathways)
BAD	GeneProduct	ENSG00000002330 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12015
BCL2	GeneProduct	ENSG00000171791 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
BCL2L11	GeneProduct	ENSG00000153094 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
BCL2L1	GeneProduct	ENSG00000171552 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
BCR	GeneProduct	102723407 (Entrez Gene)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
BDNF	GeneProduct	ENSG00000176697 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:71785
BRCA1	GeneProduct	ENSG00000012048 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
C8orf44-SGK3	GeneProduct	ENSG00000270024 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
CASP9	GeneProduct	ENSG00000132906 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12371
CCND1	GeneProduct	ENSG00000110092 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CCND2	GeneProduct	ENSG00000118971 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CCND3	GeneProduct	ENSG00000112576 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CCNE1	GeneProduct	ENSG00000105173 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CCNE2	GeneProduct	ENSG00000175305 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CD19	GeneProduct	ENSG00000177455 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
CDC37	GeneProduct	ENSG00000105401 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12539
CDK2	GeneProduct	ENSG00000123374 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CDK4	GeneProduct	ENSG00000135446 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CDK6	GeneProduct	ENSG00000105810 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CDKN1A	GeneProduct	ENSG00000124762 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12575
CDKN1B	GeneProduct	ENSG00000111276 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
CHAD	GeneProduct	ENSG00000136457 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12643
CHRM1	GeneProduct	ENSG00000168539 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12669
CHRM2	GeneProduct	ENSG00000181072 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:243764
CHUK	GeneProduct	ENSG00000213341 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16151
COL1A1	GeneProduct	ENSG00000108821 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12842
COL1A2	GeneProduct	ENSG00000164692 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12843
COL2A1	GeneProduct	ENSG00000139219 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12824
COL4A1	GeneProduct	ENSG00000187498 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12826
COL4A2	GeneProduct	ENSG00000134871 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12827
COL4A3	GeneProduct	ENSG00000169031 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12814
COL4A4	GeneProduct	ENSG00000081052 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12829
COL4A5	GeneProduct	ENSG00000188153 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12815
COL4A6	GeneProduct	ENSG00000197565 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94216
COL6A1	GeneProduct	ENSG00000142156 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12825
COL6A2	GeneProduct	ENSG00000142173 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12834
COL6A3	GeneProduct	ENSG00000163359 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12831
COL6A5	GeneProduct	ENSG00000172752 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867
COL6A6	GeneProduct	ENSG00000206384 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12832
COL9A1	GeneProduct	ENSG00000112280 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867
COL9A2	GeneProduct	ENSG00000049089 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867
COL9A3	GeneProduct	ENSG00000092758 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867
COMP	GeneProduct	ENSG00000105664 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12845
CREB1	GeneProduct	ENSG00000118260 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12912
CREB3	GeneProduct	ENSG00000107175 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12913
CREB3L1	GeneProduct	ENSG00000157613 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26427
CREB3L2	GeneProduct	ENSG00000182158 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208647
CREB3L3	GeneProduct	ENSG00000060566 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208677
CREB3L4	GeneProduct	ENSG00000143578 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78284
CREB5	GeneProduct	ENSG00000146592 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:231991
CSF1	GeneProduct	ENSG00000184371 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12977
CSF1R	GeneProduct	ENSG00000182578 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12978
CSF3	GeneProduct	ENSG00000108342 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12985
CSF3R	GeneProduct	ENSG00000119535 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
CSH1	GeneProduct	ENSG00000136488 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599
CSH2	GeneProduct	ENSG00000213218 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599
Cell Cycle	Pathway	WP179 (WikiPathways)
Cell proliferation	Pathway
Chemokine Signaling Pathway	Pathway	WP3929 (WikiPathways)
DDIT4	GeneProduct	ENSG00000168209 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
DNA Repair	Pathway	WP707 (WikiPathways)
EFNA1	GeneProduct	ENSG00000169242 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13636
EFNA2	GeneProduct	ENSG00000099617 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13637
EFNA3	GeneProduct	ENSG00000143590 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13638
EFNA4	GeneProduct	ENSG00000243364 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13639
EFNA5	GeneProduct	ENSG00000184349 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13640
EGF	GeneProduct	ENSG00000138798 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13645
EGFR	GeneProduct	ENSG00000146648 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13649
EIF4B	GeneProduct	ENSG00000063046 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75705
EIF4E1B	GeneProduct	ENSG00000175766 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:218268
EIF4E2	GeneProduct	ENSG00000135930 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26987
EIF4EBP1	GeneProduct	ENSG00000187840 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13685
EIF4E	GeneProduct	ENSG00000151247 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13684
EPHA2	GeneProduct	ENSG00000142627 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13836
EPO	GeneProduct	ENSG00000130427 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13856
EPOR	GeneProduct	ENSG00000187266 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13857
ErbB Signaling Pathway	Pathway	WP673 (WikiPathways)
F2R	GeneProduct	ENSG00000181104 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14062
FASLG	GeneProduct	ENSG00000117560 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
FGF10	GeneProduct	ENSG00000070193 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14165
FGF11	GeneProduct	ENSG00000161958 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14166
FGF12	GeneProduct	ENSG00000114279 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14167
FGF13	GeneProduct	ENSG00000129682 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80903
FGF14	GeneProduct	ENSG00000102466 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14169
FGF17	GeneProduct	ENSG00000158815 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14171
FGF18	GeneProduct	ENSG00000156427 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14172
FGF19	GeneProduct	ENSG00000162344 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14172
FGF1	GeneProduct	ENSG00000113578 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14164
FGF20	GeneProduct	ENSG00000078579 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80857
FGF21	GeneProduct	ENSG00000105550 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56636
FGF22	GeneProduct	ENSG00000070388 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67112
FGF23	GeneProduct	ENSG00000118972 (Ensembl)
FGF2	GeneProduct	ENSG00000138685 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14173
FGF3	GeneProduct	ENSG00000186895 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14174
FGF4	GeneProduct	ENSG00000075388 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14175
FGF5	GeneProduct	ENSG00000138675 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14168
FGF6	GeneProduct	ENSG00000111241 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14177
FGF7	GeneProduct	ENSG00000140285 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14178
FGF8	GeneProduct	ENSG00000107831 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14179
FGF9	GeneProduct	ENSG00000102678 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14180
FGFR1	GeneProduct	ENSG00000077782 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14182
FGFR2	GeneProduct	ENSG00000066468 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14183
FGFR3	GeneProduct	ENSG00000068078 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14184
FGFR4	GeneProduct	ENSG00000160867 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14186
FLT1	GeneProduct	ENSG00000102755 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14254
FLT3	GeneProduct	ENSG00000122025 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
FLT3LG	GeneProduct	ENSG00000090554 (Ensembl)
FLT4	GeneProduct	ENSG00000037280 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
FN1	GeneProduct	ENSG00000115414 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14268
FOXO3	GeneProduct	ENSG00000118689 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56484
Focal Adhesion	Pathway	WP306 (WikiPathways)
FoxO Signaling Pathway	Pathway
G6PC2	GeneProduct	ENSG00000152254 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
G6PC3	GeneProduct	ENSG00000141349 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
G6PC	GeneProduct	ENSG00000131482 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
GH1	GeneProduct	ENSG00000259384 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599
GH2	GeneProduct	ENSG00000136487 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14599
GHR	GeneProduct	ENSG00000112964 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14600
GNB1	GeneProduct	ENSG00000078369 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14688
GNB2	GeneProduct	ENSG00000172354 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14693
GNB3	GeneProduct	ENSG00000111664 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14695
GNB4	GeneProduct	ENSG00000114450 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14696
GNB5	GeneProduct	ENSG00000069966 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14702
GNG10	GeneProduct	ENSG00000242616 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14700
GNG11	GeneProduct	ENSG00000127920 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66066
GNG12	GeneProduct	ENSG00000172380 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14701
GNG13	GeneProduct	ENSG00000127588 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64337
GNG2	GeneProduct	ENSG00000186469 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14702
GNG3	GeneProduct	ENSG00000162188 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14704
GNG4	GeneProduct	ENSG00000168243 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14706
GNG5	GeneProduct	ENSG00000174021 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14707
GNG7	GeneProduct	ENSG00000176533 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14708
GNG8	GeneProduct	ENSG00000167414 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14709
GNGT1	GeneProduct	ENSG00000127928 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14699
GNGT2	GeneProduct	ENSG00000167083 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14710
GRB2	GeneProduct	ENSG00000177885 (Ensembl)	GRB2; growth factor receptor-bound protein 2 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14784
GSK3B	GeneProduct	ENSG00000082701 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56637
GYS1	GeneProduct	ENSG00000104812 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
GYS2	GeneProduct	ENSG00000111713 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
Glycolysis and Gluconeogenesis	Pathway	WP534 (WikiPathways)
HGF	GeneProduct	ENSG00000019991 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15234
HRAS	GeneProduct	ENSG00000174775 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
HSP90AA1	GeneProduct	ENSG00000080824 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15519
HSP90AB1	GeneProduct	ENSG00000096384 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15516
HSP90B1	GeneProduct	ENSG00000166598 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22027
IBSP	GeneProduct	ENSG00000029559 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15891
IFNA10	GeneProduct	ENSG00000186803 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15972
IFNA13	GeneProduct	ENSG00000233816 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:404549
IFNA14	GeneProduct	ENSG00000228083 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974
IFNA16	GeneProduct	ENSG00000147885 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974
IFNA17	GeneProduct	ENSG00000234829 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974
IFNA1	GeneProduct	ENSG00000197919 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15962
IFNA21	GeneProduct	ENSG00000137080 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15974
IFNA2	GeneProduct	ENSG00000188379 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15964
IFNA4	GeneProduct	ENSG00000236637 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15965
IFNA5	GeneProduct	ENSG00000147873 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15967
IFNA6	GeneProduct	ENSG00000120235 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15968
IFNA7	GeneProduct	ENSG00000214042 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15969
IFNA8	GeneProduct	ENSG00000120242 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15970
IFNAR1	GeneProduct	ENSG00000142166 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15975
IFNAR2	GeneProduct	ENSG00000159110 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15976
IFNB1	GeneProduct	ENSG00000171855 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15977
IGF1	GeneProduct	ENSG00000017427 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16000
IGF1R	GeneProduct	ENSG00000140443 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16001
IGF2	GeneProduct	ENSG00000167244 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16333
IKBKB	GeneProduct	ENSG00000104365 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16150
IKBKG	GeneProduct	ENSG00000269335 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16151
IL2	GeneProduct	ENSG00000109471 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183
IL2RA	GeneProduct	ENSG00000134460 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16184
IL2RB	GeneProduct	ENSG00000100385 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16185
IL2RG	GeneProduct	ENSG00000147168 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16186
IL3	GeneProduct	ENSG00000164399 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183
IL3RA	GeneProduct	ENSG00000185291 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16188
IL4	GeneProduct	ENSG00000113520 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183
IL4R	GeneProduct	ENSG00000077238 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16190
IL6	GeneProduct	ENSG00000136244 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183
IL6R	GeneProduct	ENSG00000160712 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16194
IL7	GeneProduct	ENSG00000104432 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16183
IL7R	GeneProduct	ENSG00000168685 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16197
INS	GeneProduct	ENSG00000254647 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16334
INSR	GeneProduct	ENSG00000171105 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337
IRS1	GeneProduct	ENSG00000169047 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16367
ITGA10	GeneProduct	ENSG00000143127 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000090210
ITGA11	GeneProduct	ENSG00000137809 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:319480
ITGA1	GeneProduct	ENSG00000213949 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:105083
ITGA2B	GeneProduct	ENSG00000005961 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16399
ITGA2	GeneProduct	ENSG00000164171 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16398
ITGA3	GeneProduct	ENSG00000005884 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16400
ITGA4	GeneProduct	ENSG00000115232 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16401
ITGA5	GeneProduct	ENSG00000161638 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16402
ITGA6	GeneProduct	ENSG00000091409 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16403
ITGA7	GeneProduct	ENSG00000135424 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16404
ITGA8	GeneProduct	ENSG00000077943 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:241226
ITGA9	GeneProduct	ENSG00000144668 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104099
ITGAV	GeneProduct	ENSG00000138448 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96608
ITGB1	GeneProduct	ENSG00000150093 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16412
ITGB3	GeneProduct	ENSG00000259207 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16416
ITGB4	GeneProduct	ENSG00000132470 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192897
ITGB5	GeneProduct	ENSG00000082781 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16419
ITGB6	GeneProduct	ENSG00000115221 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16420
ITGB7	GeneProduct	ENSG00000139626 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16421
ITGB8	GeneProduct	ENSG00000105855 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:320910
Insulin Signaling Pathway	Pathway	WP481 (WikiPathways)
JAK/STAT Signaling Pathway	Pathway	WP2593 (WikiPathways)
JAK1	GeneProduct	ENSG00000162434 (Ensembl)	CAV1; caveolin 1 caveolae protein 22kD Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16451
JAK2	GeneProduct	ENSG00000096968 (Ensembl)	CAV2; caveolin 2 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16452
JAK3	GeneProduct	ENSG00000105639 (Ensembl)	CAV3; caveolin 3 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16453
KDR	GeneProduct	ENSG00000128052 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16542
KIT	GeneProduct	ENSG00000157404 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16590
KITLG	GeneProduct	ENSG00000049130 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17311
KRAS	GeneProduct	ENSG00000133703 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16653
Kik1b4	GeneProduct
LAMA1	GeneProduct	ENSG00000101680 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16772
LAMA2	GeneProduct	ENSG00000196569 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16773
LAMA3	GeneProduct	ENSG00000053747 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024421
LAMA4	GeneProduct	ENSG00000112769 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16775
LAMA5	GeneProduct	ENSG00000130702 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16776
LAMB1	GeneProduct	ENSG00000091136 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16777
LAMB2	GeneProduct	ENSG00000172037 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16779
LAMB3	GeneProduct	ENSG00000196878 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16780
LAMB4	GeneProduct	ENSG00000091128 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53867
LAMC1	GeneProduct	ENSG00000135862 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:226519
LAMC2	GeneProduct	ENSG00000058085 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16782
LAMC3	GeneProduct	ENSG00000050555 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23928
LPAR1	GeneProduct	ENSG00000198121 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14745
LPAR2	GeneProduct	ENSG00000064547 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:53978
LPAR3	GeneProduct	ENSG00000171517 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:65086
LPAR4	GeneProduct	ENSG00000147145 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78134
LPAR5	GeneProduct	ENSG00000184574 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:381810
LPAR6	GeneProduct	ENSG00000139679 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67168
MAP2K1	GeneProduct	ENSG00000169032 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26395
MAP2K2	GeneProduct	ENSG00000126934 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26396
MAPK Signaling Pathway	Pathway	WP382 (WikiPathways)
MAPK1	GeneProduct	ENSG00000100030 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
MAPK3	GeneProduct	ENSG00000102882 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26417
MCL1	GeneProduct	ENSG00000143384 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
MDM2	GeneProduct	ENSG00000135679 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
MET	GeneProduct	ENSG00000105976 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17295
MLST8	GeneProduct	ENSG00000167965 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56716
MTOR	GeneProduct	ENSG00000198793 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56717
MYB	GeneProduct	ENSG00000118513 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
MYC	GeneProduct	ENSG00000136997 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
Mtcp1	GeneProduct		Multiple homologues found: En:ENSG00000214827;En:ENSG00000182712;
NFKB1	GeneProduct	ENSG00000109320 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
NGF	GeneProduct	ENSG00000134259 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18049
NGFR	GeneProduct	ENSG00000064300 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18053
NOS3	GeneProduct	ENSG00000164867 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
NRAS	GeneProduct	ENSG00000213281 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18176
NTF3	GeneProduct	ENSG00000185652 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18654
NTF4	GeneProduct	ENSG00000225950 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18654
NTRK1	GeneProduct	ENSG00000198400 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
NTRK2	GeneProduct	ENSG00000148053 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
Nitric oxide	Metabolite	HMDB0003378 (HMDB)
OSM	GeneProduct	ENSG00000099985 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18413
OSMR	GeneProduct	ENSG00000145623 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18414
PCK1	GeneProduct	ENSG00000124253 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
PCK2	GeneProduct	ENSG00000100889 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
PDGFA	GeneProduct	ENSG00000197461 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18590
PDGFB	GeneProduct	ENSG00000100311 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18591
PDGFC	GeneProduct	ENSG00000145431 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54635
PDGFD	GeneProduct	ENSG00000170962 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:71785
PDGFRA	GeneProduct	ENSG00000134853 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18595
PDGFRB	GeneProduct	ENSG00000113721 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18596
PDPK1	GeneProduct	ENSG00000140992 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607
PGF	GeneProduct	ENSG00000119630 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18654
PHLPP1	GeneProduct	ENSG00000081913 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:98432
PHLPP2	GeneProduct	ENSG00000040199 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:244650
PIK3AP1	GeneProduct	ENSG00000155629 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
PIK3CA	GeneProduct	ENSG00000121879 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18706
PIK3CB	GeneProduct	ENSG00000051382 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74769
PIK3CD	GeneProduct	ENSG00000171608 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18707
PIK3CG	GeneProduct	ENSG00000105851 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:30955
PIK3R1	GeneProduct	ENSG00000145675 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18708
PIK3R2	GeneProduct	ENSG00000105647 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18709
PIK3R3	GeneProduct	ENSG00000117461 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75669
PIK3R5	GeneProduct	ENSG00000141506 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:320207
PIK3R6	GeneProduct	ENSG00000276231 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:320207
PIP2	Metabolite	CHEBI:18348 (ChEBI)
PIP3	Metabolite	HMDB0004249 (HMDB)
PKN1	GeneProduct	ENSG00000123143 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
PKN2	GeneProduct	ENSG00000065243 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
PKN3	GeneProduct	ENSG00000160447 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
PPP2CA	GeneProduct	ENSG00000113575 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19052
PPP2CB	GeneProduct	ENSG00000104695 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19053
PPP2R1A	GeneProduct	ENSG00000105568 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:51792
PPP2R1B	GeneProduct	ENSG00000137713 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73699
PPP2R2A	GeneProduct	ENSG00000221914 (Ensembl)
PPP2R2B	GeneProduct	ENSG00000156475 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72930
PPP2R2C	GeneProduct	ENSG00000074211 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:269643
PPP2R2D	GeneProduct	ENSG00000175470 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:52432
PPP2R3A	GeneProduct	ENSG00000073711 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:235542
PPP2R3B	GeneProduct	ENSG00000167393 (Ensembl)
PPP2R3C	GeneProduct	ENSG00000092020 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:59032
PPP2R5A	GeneProduct	ENSG00000066027 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:226849
PPP2R5B	GeneProduct	ENSG00000068971 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:225849
PPP2R5C	GeneProduct	ENSG00000078304 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26931
PPP2R5D	GeneProduct	ENSG00000112640 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21770
PPP2R5E	GeneProduct	ENSG00000154001 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26932
PRKAA1	GeneProduct	ENSG00000132356 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:105787
PRKAA2	GeneProduct	ENSG00000162409 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108079
PRKCA	GeneProduct	ENSG00000154229 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
PRL	GeneProduct	ENSG00000172179 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19109
PRLR	GeneProduct	ENSG00000113494 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19116
PTEN	GeneProduct	ENSG00000171862 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19211
PTK2	GeneProduct	ENSG00000169398 (Ensembl)	DOCK1; dedicator of cyto-kinesis Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14083
RAC1	GeneProduct	ENSG00000136238 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16367
RAF1	GeneProduct	ENSG00000132155 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
RBL2	GeneProduct	ENSG00000103479 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
RELA	GeneProduct	5970 (Entrez Gene)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
RELN	GeneProduct	ENSG00000189056 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19699
RHEB	GeneProduct	ENSG00000106615 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19744
RPS6	GeneProduct	ENSG00000137154 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20104
RPS6KB1	GeneProduct	ENSG00000108443 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72508
RPS6KB2	GeneProduct	ENSG00000175634 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:58988
RPTOR	GeneProduct	ENSG00000141564 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74370
SGK1	GeneProduct	ENSG00000118515 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
SGK2	GeneProduct	ENSG00000101049 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
SGK3	GeneProduct	ENSG00000104205 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
SOS1	GeneProduct	ENSG00000115904 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20662
SOS2	GeneProduct	ENSG00000100485 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20662
SPP1	GeneProduct	ENSG00000118785 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20750
STK11	GeneProduct	ENSG00000118046 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74747
SYK	GeneProduct	ENSG00000165025 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
TCL1A	GeneProduct	ENSG00000100721 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21432
TCL1B	GeneProduct	ENSG00000213231 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:27379
TEK	GeneProduct	ENSG00000120156 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
TGFA	GeneProduct	ENSG00000163235 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13640
THBS1	GeneProduct	ENSG00000137801 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21825
THBS2	GeneProduct	ENSG00000186340 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21826
THBS3	GeneProduct	ENSG00000169231 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21827
THBS4	GeneProduct	ENSG00000113296 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21828
THEM4	GeneProduct	ENSG00000159445 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74343
TLR2	GeneProduct	ENSG00000137462 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
TLR4	GeneProduct	ENSG00000136869 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12986
TNC	GeneProduct	ENSG00000041982 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21923
TNN	GeneProduct	ENSG00000120332 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:329278
TNR	GeneProduct	ENSG00000116147 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21960
TNXB	GeneProduct	ENSG00000168477 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:81877
TP53	GeneProduct	ENSG00000141510 (Ensembl)	SOS1; son of sevenless homolog 1 (Drosophila) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17246
TSC1	GeneProduct	ENSG00000165699 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64930
TSC2	GeneProduct	ENSG00000103197 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22084
Toll-like Receptor Signaling Pathway	Pathway	WP75 (WikiPathways)
VEGF Signaling Pathway	Pathway	WP3888 (WikiPathways)
VEGFA	GeneProduct	ENSG00000112715 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22339
VEGFB	GeneProduct	ENSG00000173511 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22340
VEGFC	GeneProduct	ENSG00000150630 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22341
VEGFD	GeneProduct	ENSG00000165197 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14205
VTN	GeneProduct	ENSG00000109072 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22370
VWF	GeneProduct	ENSG00000110799 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22371
mTOR Signaling Pathway	Pathway

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No annotated interactions

PI3K-Akt signaling (Homo sapiens)

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