Phosphatidyl inositol phosphate pathway (Homo sapiens)

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7, 8, 17, 21INPP4APLCB3MTMR6DGPI4KAPLCG1PIP4P2PIK3C3PIK3C2APLCB1PI4K2BTPTE2MTMR1MTM1PIP4P1PLCE1PIK3C2BPI4KBPIP[3']PLCB2PIP[5']PLCD3IPMKMTMR8PTENINPP5DPLCB4PI4K2APLCG2PIP5K1CPIP2[3'4']PIK3C2GPIP4K2CPLCD1PIP4K2APIP2[3',5']SACM1LPIKFYVEPIP4K2BINPP5KFIG4PIP5K1BPLCD4MTMR2INPP4BPIP3[3',4',5']1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol)(PI)3, 14, 15, 26PIP2[4',5']2, 4, 6, 13, 18...PIP[4']PIP5K1APIK3CGPIK3CAPIK3CBPIK3CDSACM1LFIG4OCRLINPP5EINPP5EFIG4OCRLINPP5EINPP5KINPP5DPTEN


Description

Phosphatidyl inositol pathway- synthesis and degradation of PI and PI-phospatephospholipids

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Ontology Terms

 

Bibliography

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  1. Delage E, Puyaubert J, Zachowski A, Ruelland E; ''Signal transduction pathways involving phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: convergences and divergences among eukaryotic kingdoms.''; Prog Lipid Res, 2013 PubMed Europe PMC Scholia
  2. Kwiatkowska K; ''One lipid, multiple functions: how various pools of PI(4,5)P(2) are created in the plasma membrane.''; Cell Mol Life Sci, 2010 PubMed Europe PMC Scholia
  3. Gehrmann T, Heilmeyer LM Jr; ''Phosphatidylinositol 4-kinases.''; Eur J Biochem, 1998 PubMed Europe PMC Scholia
  4. Nakagawa Y, Waku K; ''The metabolism of glycerophospholipid and its regulation in monocytes and macrophages.''; Prog Lipid Res, 1989 PubMed Europe PMC Scholia
  5. Large WA, Saleh SN, Albert AP; ''Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle.''; Cell Calcium, 2009 PubMed Europe PMC Scholia
  6. Balla T; ''Phosphatidylinositol 4-kinases.''; Biochim Biophys Acta, 1998 PubMed Europe PMC Scholia
  7. Arienti G, Goracci G, Porcellati G; ''Glycerophospholipid metabolism in neuronal and glial cell-enriched fractions.''; Neurochem Res, 1981 PubMed Europe PMC Scholia
  8. Rameh LE, Tolias KF, Duckworth BC, Cantley LC; ''A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.''; Nature, 1997 PubMed Europe PMC Scholia
  9. Hirasawa K, Nishizuka Y; ''Phosphatidylinositol turnover in receptor mechanism and signal transduction.''; Annu Rev Pharmacol Toxicol, 1985 PubMed Europe PMC Scholia
  10. Thomas JR, Dwek RA, Rademacher TW; ''Structure, biosynthesis, and function of glycosylphosphatidylinositols.''; Biochemistry, 1990 PubMed Europe PMC Scholia
  11. Divecha N; ''Lipid kinases: charging PtdIns(4,5)P2 synthesis.''; Curr Biol, 2010 PubMed Europe PMC Scholia
  12. Takenawa T, Itoh T, Fukami K; ''Regulation of phosphatidylinositol 4,5-bisphosphate levels and its roles in cytoskeletal re-organization and malignant transformation.''; Chem Phys Lipids, 1999 PubMed Europe PMC Scholia
  13. Meyers RE, Cantley LC; ''Phosphatidylinositol 4-kinases. Assays and product analysis.''; Methods Mol Biol, 1998 PubMed Europe PMC Scholia
  14. Lamers JM, Dekkers DH, Bezstarosti K, Meij JT, van Heugten HA; ''Occurrence and functions of the phosphatidylinositol cycle in the myocardium.''; Mol Cell Biochem, 1992 PubMed Europe PMC Scholia
  15. Gupta CM, Radhakrishnan R, Khorana HG; ''Glycerophospholipid synthesis: improved general method and new analogs containing photoactivable groups.''; Proc Natl Acad Sci U S A, 1977 PubMed Europe PMC Scholia
  16. Insall RH, Weiner OD; ''PIP3, PIP2, and cell movement--similar messages, different meanings?''; Dev Cell, 2001 PubMed Europe PMC Scholia
  17. Gamper N, Shapiro MS; ''Target-specific PIP(2) signalling: how might it work?''; J Physiol, 2007 PubMed Europe PMC Scholia
  18. Downes CP, Carter AN; ''Inositol lipids and phosphates.''; Curr Opin Cell Biol, 1990 PubMed Europe PMC Scholia
  19. Zhang L, Mao YS, Janmey PA, Yin HL; ''Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton.''; Subcell Biochem, 2012 PubMed Europe PMC Scholia
  20. Heilmeyer LM Jr, Vereb G Jr, Vereb G, Kakuk A, Szivák I; ''Mammalian phosphatidylinositol 4-kinases.''; IUBMB Life, 2003 PubMed Europe PMC Scholia
  21. Suh BC, Hille B; ''Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate.''; Curr Opin Neurobiol, 2005 PubMed Europe PMC Scholia
  22. Graham TR, Burd CG; ''Coordination of Golgi functions by phosphatidylinositol 4-kinases.''; Trends Cell Biol, 2011 PubMed Europe PMC Scholia
  23. Sinha RK, Subrahmanyam G; ''Type II phosphatidylinositol 4-kinase(s) in cell signaling cascades.''; Indian J Biochem Biophys, 2007 PubMed Europe PMC Scholia
  24. Holmsen H, Hindenes JO, Fukami M; ''Glycerophospholipid metabolism: back to the future.''; Thromb Res, 1992 PubMed Europe PMC Scholia
  25. Huang CL; ''Complex roles of PIP2 in the regulation of ion channels and transporters.''; Am J Physiol Renal Physiol, 2007 PubMed Europe PMC Scholia
  26. Clayton EL, Minogue S, Waugh MG; ''Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases.''; Mol Neurobiol, 2013 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134418view23:00, 21 July 2024EweitzEconomize layout
127750view10:47, 1 December 2023Conroy lipidsModified description
127220view15:01, 22 August 2023Conroy lipids
127219view13:29, 22 August 2023Conroy lipidsupdate with info from P Hawkins
127207view14:48, 16 August 2023Conroy lipids
127206view14:47, 16 August 2023Conroy lipids
127205view14:45, 16 August 2023Conroy lipids
127204view14:43, 16 August 2023Conroy lipids
127203view14:43, 16 August 2023Conroy lipids
127202view14:41, 16 August 2023Conroy lipidsNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol) (PI)MetaboliteLMGP06010000 (LIPID MAPS)
DGMetaboliteLMGL02010000 (LIPID MAPS)
FIG4GeneProductQ92562 (Uniprot-TrEMBL)
INPP4AGeneProductQ96PE3 (Uniprot-TrEMBL)
INPP4BGeneProductO15327 (Uniprot-TrEMBL)
INPP5DGeneProductQ92835 (Uniprot-TrEMBL)
INPP5EGeneProductQ9NRR6 (Uniprot-TrEMBL)
INPP5KGeneProductQ9BT40 (Uniprot-TrEMBL)
IPMKProteinQ8NFU5 (Uniprot-TrEMBL)
MTM1GeneProductQ13496 (Uniprot-TrEMBL)
MTMR1GeneProductQ13613 (Uniprot-TrEMBL)
MTMR2GeneProductQ13614 (Uniprot-TrEMBL)
MTMR6GeneProductQ9Y217 (Uniprot-TrEMBL)
MTMR8GeneProductQ96EF0 (Uniprot-TrEMBL)
OCRLGeneProductQ01968 (Uniprot-TrEMBL)
PI4K2AGeneProductQ9BTU6 (Uniprot-TrEMBL)
PI4K2BGeneProductQ8TCG2 (Uniprot-TrEMBL)
PI4KAGeneProductP42356 (Uniprot-TrEMBL)
PI4KBGeneProductQ9UBF8 (Uniprot-TrEMBL)
PIK3C2AGeneProductO00443 (Uniprot-TrEMBL)
PIK3C2BGeneProductO00750 (Uniprot-TrEMBL)
PIK3C2GGeneProductO75747 (Uniprot-TrEMBL)
PIK3C3GeneProductP42338 (Uniprot-TrEMBL)
PIK3CAProteinP42336 (Uniprot-TrEMBL)
PIK3CBProteinP42338 (Uniprot-TrEMBL)
PIK3CDProteinO00329 (Uniprot-TrEMBL)
PIK3CGProteinP48736 (Uniprot-TrEMBL)
PIKFYVEGeneProductQ9Y2I7 (Uniprot-TrEMBL)
PIP2[3',5']MetaboliteLMGP08010007 (LIPID MAPS)
PIP2[3'4']MetaboliteLMGP08010006 (LIPID MAPS)
PIP2[4',5']MetaboliteLMGP08010005 (LIPID MAPS)
PIP3[3',4',5']MetaboliteLMGP09010000 (LIPID MAPS)
PIP4K2AGeneProductP48426 (Uniprot-TrEMBL)
PIP4K2BGeneProductP78356 (Uniprot-TrEMBL)
PIP4K2CGeneProductQ8TBX8 (Uniprot-TrEMBL)
PIP4P1GeneProductQ86T03 (Uniprot-TrEMBL)
PIP4P2GeneProductQ8N4L2 (Uniprot-TrEMBL)
PIP5K1AProteinQ99755 (Uniprot-TrEMBL)
PIP5K1BGeneProductO14986 (Uniprot-TrEMBL)
PIP5K1CGeneProductO60331 (Uniprot-TrEMBL)
PIP[3']MetaboliteLMGP07010000 (LIPID MAPS)
PIP[4']MetaboliteLMGP070100A0 (LIPID MAPS)
PIP[5']MetaboliteLMGP070100B0 (LIPID MAPS)
PLCB1GeneProductQ9NQ66 (Uniprot-TrEMBL)
PLCB2GeneProductQ00722 (Uniprot-TrEMBL)
PLCB3GeneProductQ01970 (Uniprot-TrEMBL)
PLCB4GeneProductQ15147 (Uniprot-TrEMBL)
PLCD1GeneProductP51178 (Uniprot-TrEMBL)
PLCD3GeneProductQ8N3E9 (Uniprot-TrEMBL)
PLCD4GeneProductQ9BRC7 (Uniprot-TrEMBL)
PLCE1GeneProductQ9P212 (Uniprot-TrEMBL)
PLCG1GeneProductP19174 (Uniprot-TrEMBL)
PLCG2GeneProductP16885 (Uniprot-TrEMBL)
PTENGeneProductP60484 (Uniprot-TrEMBL)
SACM1LGeneProductQ9NTJ5 (Uniprot-TrEMBL)
TPTE2GeneProductQ6XPS3 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol) (PI)PIP[3']mim-conversion12710 (Rhea) EC:2.7.1.137
1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol) (PI)PIP[4']mim-conversion19878 (Rhea) EC:2.7.1.67
PIP2[3',5']PIP[3']mim-conversion32956 (Rhea)
PIP2[3',5']PIP[5']mim-conversion39020 (Rhea) EC:3.1.3.95
PIP2[3'4']PIP[3']mim-conversion17194 (Rhea) EC:3.1.3.66
PIP2[4',5']DGmim-conversion33180 (Rhea) EC:3.1.4.11
PIP2[4',5']PIP3[3',4',5']mim-conversion21293 (Rhea) EC:2.7.1.153
PIP2[4',5']PIP[4']mim-conversion22765 (Rhea) EC:3.1.3.36
PIP2[4',5']PIP[5']mim-conversion25674 (Rhea) EC:3.1.3.78
PIP3[3',4',5']PIP2[3'4']mim-conversion25529 (Rhea) EC:3.1.3.86
PIP3[3',4',5']PIP2[4',5']mim-conversion25018 (Rhea) EC:3.1.3.67
PIP[3']1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol) (PI)mim-conversion12317 (Rhea) EC:3.1.3.64
PIP[3']PIP2[3',5']mim-conversion13610 (Rhea) EC:2.7.1.150
PIP[4']1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol) (PI)mim-conversion55653 (Rhea)
PIP[4']PIP2[4',5']mim-conversion14426 (Rhea) EC:2.7.1.68
PIP[5']PIP2[4',5']mim-conversion12281 (Rhea) EC:2.7.1.149
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