High-osmolarity glycerol (HOG) pathway (Saccharomyces cerevisiae)

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PP2C3NucleusCytoplasm1, 2ZymolyaseHeat shockAcetic acidTranscriptional ResponseCsClOxidative stressHyperosmotic stressSSK22SSK1YPD1CLA4HOG1SLN1SKO1MSN4PTC1PTP2HKR1STE50PBS2HOT1OPY2STE11SMP1CDC42STE20SSK2MSB2HOG1MSN2SHO1


Description

The high-osmolarity glycerol (HOG) pathway is a mitogen-activated protein kinase (MAPK) pathway that regulates stress response in Saccharomyces cerevisiae mainly as it relates to the adaptation of yeast cells to hyperosmotic stress. Two input branches activate the MAPK module by different mechanisms. The Sho1 branch requires Sho1p and the mucin-like proteins Hkr1p and Msb2p to sense osmostress. Sho1p-dependent signalling also requires small G-protein Cdc42p, and PAK family members Ste20 and Cla4. The target of Ste20p is the MAPKKK Ste11p, which activates the MAPKK Pbs2p under hyperosmotic conditions, resulting in Hog1p activation. Another branch, leading to the activation of Pbs2, involves a ‘two-component’ phospho-relay signalling system that involves transmembrane protein Sln1p and response regulator proteins Ypd1p and Ssk1p. In this branch, the two redundant MAPKKKs Ssk2p and Ssk22p participate in the phosphorylation of Pbs2p, which is responsible for the final activation of Hog1p. Once Hog1p is activated, it coordinates several processes necessary for cellular adaptation to osmotic stress, including ubiquitination, chromatin remodelling, the transcriptional program, mRNA export, translational response, and cell cycle progression. In addition to its main role in the regulation of hyperosmotic stress responses, the HOG pathway is also activated in response to oxidatiion, acids stress, organic compounds, metals, and freeze or heat stress.

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Bibliography

  1. Hohmann S; ''Control of high osmolarity signalling in the yeast Saccharomyces cerevisiae.''; FEBS Lett, 2009 PubMed Europe PMC Scholia
  2. Rodríguez-Peña JM, García R, Nombela C, Arroyo J; ''The high-osmolarity glycerol (HOG) and cell wall integrity (CWI) signalling pathways interplay: a yeast dialogue between MAPK routes.''; Yeast, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
127796view00:33, 15 December 2023KhanspersModified description
127795view00:32, 15 December 2023Khanspersupdated node labels, cleaned up layout, connected interactions, added groups/complexes
117077view14:48, 16 May 2021EweitzModified title
77924view17:41, 30 October 2014StaciaPeriodical save, work in progress
77663view07:41, 4 October 2014EgonwReplaced 'Uniprot-SwissProt' by 'Uniprot-TrEMBL'.
77435view14:17, 8 September 2014EgonwConnected dots.
77369view08:30, 29 August 2014ElisaModified title
77351view20:10, 26 August 2014KhanspersOntology Term : 'stress response pathway' added !
77350view20:10, 26 August 2014KhanspersOntology Term : 'mitogen activated protein kinase signaling pathway' added !
77301view21:05, 13 August 2014StaciaSpecify description
77300view21:00, 13 August 2014StaciaPeriodical save, work in progress
77299view20:50, 13 August 2014StaciaPeriodical save, work in progress
77298view20:48, 13 August 2014StaciaSpecify description
77297view20:40, 13 August 2014StaciaPeriodical save, work in progress
77296view20:30, 13 August 2014StaciaPeriodical save, work in progress
77295view17:48, 13 August 2014Staciaadded literature
77294view17:36, 13 August 2014StaciaOntology Term : 'regulatory pathway' added !
77293view17:32, 13 August 2014StaciaModified description
77292view17:26, 13 August 2014StaciaOntology Term : 'signaling pathway' added !
77291view17:24, 13 August 2014StaciaModified description
77289view14:38, 13 August 2014StaciaPeriodical save, work in progress
77286view00:04, 13 August 2014StaciaSpecify description
77285view23:54, 12 August 2014StaciaPeriodical save, work in progress
77284view23:52, 12 August 2014StaciaSpecify description
77283view23:44, 12 August 2014StaciaPeriodical save, work in progress
77282view23:34, 12 August 2014StaciaPeriodical save, work in progress
77281view23:29, 12 August 2014StaciaSpecify description
77280view23:24, 12 August 2014StaciaPeriodical save, work in progress
77279view23:20, 12 August 2014StaciaHOG pathway
77278view23:14, 12 August 2014StaciaPeriodical save, work in progress
77277view22:54, 12 August 2014StaciaPeriodical save, work in progress
77276view22:44, 12 August 2014StaciaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CDC42ProteinP19073 (Uniprot-TrEMBL)
CLA4ProteinP48562 (Uniprot-TrEMBL)
HKR1ProteinP41809 (Uniprot-TrEMBL)
HOG1ProteinP32485 (Uniprot-TrEMBL)
HOT1ProteinQ03213 (Uniprot-TrEMBL)
MSB2ProteinP32334 (Uniprot-TrEMBL)
MSN2ProteinP33748 (Uniprot-TrEMBL)
MSN4ProteinP33749 (Uniprot-TrEMBL)
OPY2ProteinQ06810 (Uniprot-TrEMBL)
PBS2ProteinP08018 (Uniprot-TrEMBL)
PP2C3ProteinP34221 (Uniprot-TrEMBL)
PTC1ProteinP35182 (Uniprot-TrEMBL)
PTP2ProteinP29461 (Uniprot-TrEMBL)
SHO1ProteinP40073 (Uniprot-TrEMBL)
SKO1ProteinQ02100 (Uniprot-TrEMBL)
SLN1ProteinP39928 (Uniprot-TrEMBL)
SMP1ProteinP38128 (Uniprot-TrEMBL)
SSK1ProteinQ07084 (Uniprot-TrEMBL)
SSK22ProteinP25390 (Uniprot-TrEMBL)
SSK2ProteinP53599 (Uniprot-TrEMBL)
STE11ProteinP23561 (Uniprot-TrEMBL)
STE20ProteinQ03497 (Uniprot-TrEMBL)
STE50ProteinP25344 (Uniprot-TrEMBL)
YPD1ProteinQ07688 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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