Cell cycle (Drosophila melanogaster)

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ORC(origin recognition complex)e+uCondensin+pS-phase proteins+pApoptosisp16,15,18,19p21APC/CMCM-p+u+pR-pointGrowth factorTranscription factor E2FG2+p+pORC+p+u+pee+u+pSE2F+pee(Start)+pSCF+pDNASCF+p+pAPC/CMHDACSeparin+p-pMCM (mini-chromosomemaintenance) complexG1DNA biosynthesisDNA damage checkpoint+p+pHistone deacetylasesGrowth factorwithdrawal+uDNAp27,57+pSecurinmus209HDAC6PTTG3HDAC7AMcm6CycB3CG7134MDM2MAD2L2PTTG2Orc4CDK4CDKN1AlokstgOrc2ESPL1BUB1latCCND3CG9772HDAC8HDAC4CycHCycAMPEG1E2F3Mcm5SMC1nejCCNB2ARFPTTG1dpaE2F1CDKN1Bmad2RB1PKMYT1weeCCNA1ATR14-3-3tefutweCycBASKBub3CycDMcm7YWHAGMedUbituitinmediatedproteolysisE2F4Mcm3CDK2Orc6MENpoloCDKN2ARB1grpCycEHDAC1sggCDH1CDC25BBUB1Bcdc2Orc1CDC45Ll(1)G0148Hdac3TXBP181-likeCCNA1CycAMcm2CDK2RB1RbfUBE2FOrc5HDAC5CDK2CG9772cdc2fzyPRKDCE2F2SMAD3TFDP1GADD45ACDC14BTBC1D8Cdk4TP53RbfE2F6Rpd3CCNE2TGFB1E2f2ABL1MAPKsignalingpathwayCG5971


Description

(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Comments

GenMAPP notes 
Adapted from: http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html

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Bibliography

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History

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CompareRevisionActionTimeUserComment
127991view23:40, 20 January 2024EweitzStandardize pathway nodes
127990view23:35, 20 January 2024EweitzUse one object for multiline labels; standardize case
89524view11:03, 16 September 2016Mkutmonontology tag fix
77399view22:32, 5 September 2014MaintBotremoved homology mapp label
71546view19:25, 17 October 2013MaintBotAutomated update of data sources
68712view21:38, 6 July 2013MaintBotUpdated to 2013 gpml schema
67103view10:06, 26 June 2013Christine ChichesterOntology Term : 'cell cycle pathway, mitotic' added !
62798view16:46, 2 May 2013MaintBotUpdated UniProt data source
40879view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35364view09:13, 12 February 2010MartijnVanIerselModified description
34156view21:07, 9 December 2009MaintBotAutomatic update of empty xrefs
20743view11:29, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:Cell cycle KEGG]] moved to [[Pathway:WP31]]: Moved to stable identifier
8510view14:01, 7 January 2008MaintBotAdded to category $category
19396view14:01, 7 January 2008BruceConklinUploaded new pathway
8508view14:01, 7 January 2008NsalomonisUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
14-3-3GeneProduct
ABL1GeneProductABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
ARFGeneProduct
ASKGeneProductASK; activator of S phase kinas
ATRGeneProductA1AU_HUMAN (Uniprot-TrEMBL) ATR; ataxia telangiectasia and Rad3 related
BUB1GeneProduct33758 (Entrez Gene) BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
BUB1BGeneProductBUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
Bub3GeneProduct43490 (Entrez Gene) BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
CCNA1GeneProductCCNA1; cyclin A1
CCNB2GeneProductCCNB2; cyclin B2
CCND3GeneProductCCND3; cyclin D3
CCNE2GeneProductCCNE2; cyclin E
CDC14BGeneProductCDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
CDC25BGeneProductCDC25B; cell division cycle 25B [EC:3.1.3.48]
CDC45LGeneProduct31052 (Entrez Gene) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
CDH1GeneProduct
CDK2GeneProductCDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDK4GeneProduct36854 (Entrez Gene) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDKN1AGeneProduct
CDKN1BGeneProductCDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN2AGeneProduct
CG5971GeneProduct38989 (Entrez Gene) CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
CG7134GeneProduct34067 (Entrez Gene) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
CG9772GeneProduct40548 (Entrez Gene) SKP2; S-phase kinase-associated protein 2 (p45
Cdk4GeneProduct36854 (Entrez Gene) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CycAGeneProduct39340 (Entrez Gene) CCNA2; cyclin A2
CycB3GeneProduct42971 (Entrez Gene) CCNB3; cyclin B
CycBGeneProduct37618 (Entrez Gene) CCNB1; cyclin B1
CycDGeneProduct32551 (Entrez Gene) CCND2; cyclin D2
CycEGeneProduct34924 (Entrez Gene) CCNE1; cyclin E
CycHGeneProduct40429 (Entrez Gene) CCNH; cyclin H
E2F1GeneProductE2F1; E2F transcription factor 1
E2F2GeneProduct35381 (Entrez Gene) E2F2; E2F transcription factor 2
E2F3GeneProductE2F3; E2F transcription factor 3
E2F4GeneProductE2F4; E2F transcription factor 4 p107/p130-binding
E2F6GeneProductE2F6; E2F transcription factor 6
E2f2GeneProduct35381 (Entrez Gene) E2F5; E2F transcription factor 5 p130-binding
ESPL1GeneProductESPL1; extra spindle poles like 1 (S. cerevisiae
GADD45AGeneProduct
HDAC1GeneProductHDAC1; histone deacetylase 1
HDAC4GeneProduct32278 (Entrez Gene) HDAC4; histone deacetylase 4
HDAC5GeneProductHDAC5; histone deacetylase 5
HDAC6GeneProduct32461 (Entrez Gene) HDAC6; histone deacetylase 6
HDAC7AGeneProductHDAC7A; histone deacetylase 7
HDAC8GeneProductHDAC8; histone deacetylase
Hdac3GeneProduct44446 (Entrez Gene) HDAC3; histone deacetylase 3
MAD2L2GeneProductMAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
MAPK

signaling

pathway		Pathway
MDM2GeneProductMDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
MENGeneProduct47173 (Entrez Gene)
MPEG1GeneProduct
Mcm2GeneProduct40973 (Entrez Gene) MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
Mcm3GeneProduct31449 (Entrez Gene) MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
Mcm5GeneProduct41296 (Entrez Gene) MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
Mcm6GeneProduct31603 (Entrez Gene) MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
Mcm7GeneProduct39014 (Entrez Gene) MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
MedGeneProduct43725 (Entrez Gene) MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
Orc1GeneProduct35686 (Entrez Gene) ORC1L; origin recognition complex subunit 1-like (yeast)
Orc2GeneProduct41703 (Entrez Gene) ORC2L; origin recognition complex subunit 2-like (yeast)
Orc4GeneProduct37970 (Entrez Gene) ORC4L; origin recognition complex subunit 4-like (yeast)
Orc5GeneProduct34794 (Entrez Gene) ORC5L; origin recognition complex subunit 5-like (yeast)
Orc6GeneProduct36017 (Entrez Gene) ORC6L; origin recognition complex subunit 6-like (yeast)
PKMYT1GeneProductPKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
PRKDCGeneProductPRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
PTTG1GeneProductPTTG1; pituitary tumor-transforming
PTTG2GeneProductPTTG2; pituitary tumor-transforming
PTTG3GeneProductPTTG3; pituitary tumor-transforming
RB1GeneProductRB1; retinoblastoma 1 (including osteosarcoma)
RbfGeneProduct31027 (Entrez Gene)
Rpd3GeneProduct38565 (Entrez Gene) HDAC2; histone deacetylase 2
SMAD3GeneProductMADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
SMC1GeneProduct42853 (Entrez Gene) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
TBC1D8GeneProduct
TFDP1GeneProductTFDP1; transcription factor Dp-1
TGFB1GeneProduct
TP53GeneProduct
TXBP181-likeGeneProduct35954 (Entrez Gene) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
UBE2FGeneProductUBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
Ubituitin

mediated

proteolysis		Pathway
YWHAGGeneProductYWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
cdc2GeneProduct34411 (Entrez Gene) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
dpaGeneProduct35679 (Entrez Gene) MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
fzyGeneProduct34968 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
grpGeneProduct34993 (Entrez Gene) CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
l(1)G0148GeneProduct31598 (Entrez Gene) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
latGeneProduct36454 (Entrez Gene) ORC3L; origin recognition complex subunit 3-like (yeast)
lokGeneProduct35288 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
mad2GeneProduct38656 (Entrez Gene) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
mus209GeneProduct37290 (Entrez Gene) PCNA; proliferating cell nuclear antigen
nejGeneProduct43856 (Entrez Gene) EP300; E1A binding protein p300
poloGeneProduct40232 (Entrez Gene) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
sggGeneProduct31248 (Entrez Gene) GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
stgGeneProduct43466 (Entrez Gene) CDC25A; cell division cycle 25A [EC:3.1.3.48]
tefuGeneProduct41839 (Entrez Gene) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
tweGeneProduct34954 (Entrez Gene) CDC25C; cell division cycle 25C [EC:3.1.3.48]
weeGeneProduct33965 (Entrez Gene) WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]

Annotated Interactions

No annotated interactions
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