This pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references.
Karchin R, Karplus K, Haussler D; ''Classifying G-protein coupled receptors with support vector machines''; Bioinformatics, 2002 PubMedEurope PMCScholia
Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, Edvardsen O, Campagne F, Vriend G.; ''GPCRDB: an information system for G protein-coupled receptors''; Nucleic Acids Research , 1998 PubMedEurope PMCScholia
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