PCSK9-mediated LDL receptor degradation (Homo sapiens)
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Description
Exogenously, circulating PCSK9 (Proprotein convertase subtilisin/kexin type 9) protein binds to LDLR (LDL receptor). Once internalized into the liver cell, the PCSK9 protein directs the LDLR to the lysosome for degradation. Intrinsically, PCSK9, which is secreted from the Golgi apparatus, binds the LDLR before it reaches the cell surface, leading it to lysosomal degradation. However, the precise mechanisms by which the intrinsic degradation pathway operates are still unknown. Abbreviations: LDLR, LDL receptor; PCSK9, proprotein convertase subtilisin/kexin type 9.
Quality Tags
Ontology Terms
Bibliography
- Brautbar A, Ballantyne CM; ''Pharmacological strategies for lowering LDL cholesterol: statins and beyond.''; Nat Rev Cardiol, 2011 PubMed Europe PMC Scholia
History
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External references
DataNodes
Name | Type | Database reference | Comment |
---|---|---|---|
LDL cholesterol | Metabolite | 47774 (ChEBI) | |
LDLR | GeneProduct | ENSG00000130164 (Ensembl) | |
PCSK9 | GeneProduct | ENSG00000169174 (Ensembl) |
Annotated Interactions
No annotated interactions