Artemisinin inhibition of uveal melanoma (Homo sapiens)

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1GrowthMitochondrialpotentialReceptor tyrosine kinaseApoptosisArtemisininPI3KAKTMTORMigrationInvasion


Description

Farhan et al. (2021) note: "By acting in PI3K/AKT/mTOR, a pathway with recognized importance in cancer, artemisinin was shown to be able to impair the migration, invasion, and proliferation of UM cells." This pathway diagram was derived from https://pfocr.wikipathways.org/figures/PMC8684509__OMCL2021-9911537.012.html.

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Ontology Terms

 

Bibliography

  1. Farhan M, Silva M, Xingan X, Zhou Z, Zheng W; ''Artemisinin Inhibits the Migration and Invasion in Uveal Melanoma via Inhibition of the PI3K/AKT/mTOR Signaling Pathway.''; Oxid Med Cell Longev, 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129817view22:22, 22 May 2024EweitzEconomize layout
129816view22:01, 22 May 2024EweitzExtract 14 genes for PI3K family to separate pathway
129812view21:42, 22 May 2024EweitzExtract 40 genes in RTK family from legend to annotated list pathway
129805view21:17, 22 May 2024EweitzTailor node dimensions
128501view13:41, 10 February 2024EweitzCenter group labels in legend
128500view13:23, 10 February 2024EweitzShow PI3K family by class in legend
128490view23:01, 6 February 2024EweitzLegend AKT members, refine AKT node type
128489view21:54, 6 February 2024EweitzLeft-flush label and nodes for inner groups
128488view21:47, 6 February 2024EweitzApply stack horizontal center to RTK members
128487view21:43, 6 February 2024EweitzComplete raw nodes for RTK family genes, by class
128486view21:17, 6 February 2024EweitzDraft RTK gene family members
128485view21:15, 6 February 2024EweitzReverted to version '23:58, 5 February 2024' by Eweitz
128484view21:14, 6 February 2024EweitzReverted to version '23:56, 5 February 2024' by Eweitz
128482view23:58, 5 February 2024EweitzModified description
128481view23:56, 5 February 2024EweitzPer feedback: connect RTK and PI3K, delegend AKT, legend triangles (https://github.com/wikipathways/wikipathways-help/issues/104)
128352view13:39, 2 February 2024EweitzAdd mitochondrion graphic
128351view13:35, 2 February 2024EweitzRefine identifiers, add legend, enrich level triangles
128348view04:59, 2 February 2024EweitzOntology Term : 'drug pathway' added !
128347view04:58, 2 February 2024EweitzOntology Term : 'melanoma' added !
128346view04:58, 2 February 2024EweitzOntology Term : 'uveal cancer' added !
128345view04:57, 2 February 2024EweitzOntology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
128344view04:33, 2 February 2024EweitzIdentify nodes
128343view03:26, 2 February 2024EweitzModified description
128342view03:25, 2 February 2024EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKTGeneProduct
ApoptosisPathwayWP254 (WikiPathways)
ArtemisininMetabolite
MTORGeneProduct
PI3KGeneProduct
Receptor

tyrosine

kinase		GeneProduct

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5441"
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