Artemisinin inhibition of uveal melanoma (Homo sapiens)
From WikiPathways
Description
Farhan et al. (2021) note: "By acting in PI3K/AKT/mTOR, a pathway with recognized importance in cancer, artemisinin was shown to be able to impair the migration, invasion, and proliferation of UM cells." This pathway diagram was derived from https://pfocr.wikipathways.org/figures/PMC8684509__OMCL2021-9911537.012.html.
Quality Tags
Ontology Terms
Bibliography
- Farhan M, Silva M, Xingan X, Zhou Z, Zheng W; ''Artemisinin Inhibits the Migration and Invasion in Uveal Melanoma via Inhibition of the PI3K/AKT/mTOR Signaling Pathway.''; Oxid Med Cell Longev, 2021 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AKT1 | GeneProduct | ENSG00000142208 (Ensembl) | |
AKT | GeneProduct | 2.7.11.1 (Enzyme Nomenclature) | |
AKT2 | GeneProduct | ENSG00000105221 (Ensembl) | |
AKT3 | GeneProduct | ENSG00000117020 (Ensembl) | |
Apoptosis | Pathway | WP254 (WikiPathways) | |
Artemisinin | Metabolite | 223316 (ChEBI) | |
MTOR | GeneProduct | ENSG00000198793 (Ensembl) | |
PI3K | GeneProduct | 2.7.1.137 (Enzyme Nomenclature) | |
Receptor
tyrosine kinase | GeneProduct | 2.7.10.1 (Enzyme Nomenclature) |
Annotated Interactions
No annotated interactions