Artemisinin inhibition of uveal melanoma (Homo sapiens)

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1GrowthMitochondrialpotentialIncreaseAKTLegendReceptor tyrosine kinaseApoptosisArtemisininPI3KMTORMigrationInvasionAKT1AKT2AKT3DecreaseReceptor tyrosine kinaseClass I: EGFREGFRERBB2ERBB3ERBB4Class II: Insulin RINSRIGFRClass III: PDGFRPDGFRAPDGFRBM-CSFRKITClass IV: VEGFRVEGFR1VEGFR2VEGFR3Class V: FGFRFGFR1FGFR2FGFR3FGFR4Class VI: CCKCCK4Class VII: NGFRTRKATRKBTRKCClass VIII: HGFRMETRONFLT3LClass IX: FGFREPHA1EPHA2EPHA3EPHA4EPHA5EPHA6EPHB1EPHB2EPHB3EPHB4EPHB5EPHB6Class XI: TIETIETEKClass XII: RYKRYKClass XIII: DDRDDR1DDR2Class XIV: RETRETClass XV: ROSROSClass XVI: LTKLTKALKClass XVII: RORROR1ROR2Class XVIII: MUSKMUSKClass XX:METRONMETRONClass XIX: LMRClass X: AXLEGFRERBB2ERBB3AATYK1AATYK2AATYK3


Description

Farhan et al. (2021) note: "By acting in PI3K/AKT/mTOR, a pathway with recognized importance in cancer, artemisinin was shown to be able to impair the migration, invasion, and proliferation of UM cells." Triangles indicate an increase or decrease in the adjacent entity. This pathway diagram was derived from https://pfocr.wikipathways.org/figures/PMC8684509__OMCL2021-9911537.012.html.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Farhan M, Silva M, Xingan X, Zhou Z, Zheng W; ''Artemisinin Inhibits the Migration and Invasion in Uveal Melanoma via Inhibition of the PI3K/AKT/mTOR Signaling Pathway.''; Oxid Med Cell Longev, 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129817view22:22, 22 May 2024EweitzEconomize layout
129816view22:01, 22 May 2024EweitzExtract 14 genes for PI3K family to separate pathway
129812view21:42, 22 May 2024EweitzExtract 40 genes in RTK family from legend to annotated list pathway
129805view21:17, 22 May 2024EweitzTailor node dimensions
128501view13:41, 10 February 2024EweitzCenter group labels in legend
128500view13:23, 10 February 2024EweitzShow PI3K family by class in legend
128490view23:01, 6 February 2024EweitzLegend AKT members, refine AKT node type
128489view21:54, 6 February 2024EweitzLeft-flush label and nodes for inner groups
128488view21:47, 6 February 2024EweitzApply stack horizontal center to RTK members
128487view21:43, 6 February 2024EweitzComplete raw nodes for RTK family genes, by class
128486view21:17, 6 February 2024EweitzDraft RTK gene family members
128485view21:15, 6 February 2024EweitzReverted to version '23:58, 5 February 2024' by Eweitz
128484view21:14, 6 February 2024EweitzReverted to version '23:56, 5 February 2024' by Eweitz
128482view23:58, 5 February 2024EweitzModified description
128481view23:56, 5 February 2024EweitzPer feedback: connect RTK and PI3K, delegend AKT, legend triangles (https://github.com/wikipathways/wikipathways-help/issues/104)
128352view13:39, 2 February 2024EweitzAdd mitochondrion graphic
128351view13:35, 2 February 2024EweitzRefine identifiers, add legend, enrich level triangles
128348view04:59, 2 February 2024EweitzOntology Term : 'drug pathway' added !
128347view04:58, 2 February 2024EweitzOntology Term : 'melanoma' added !
128346view04:58, 2 February 2024EweitzOntology Term : 'uveal cancer' added !
128345view04:57, 2 February 2024EweitzOntology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
128344view04:33, 2 February 2024EweitzIdentify nodes
128343view03:26, 2 February 2024EweitzModified description
128342view03:25, 2 February 2024EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AATYK1GeneProduct
AATYK2GeneProduct
AATYK3GeneProduct
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
ALKGeneProduct
ApoptosisPathwayWP254 (WikiPathways)
ArtemisininMetabolite223316 (ChEBI)
CCK4GeneProduct
DDR1GeneProduct
DDR2GeneProduct
EGFRGeneProduct
EPHA1GeneProduct
EPHA2GeneProduct
EPHA3GeneProduct
EPHA4GeneProduct
EPHA5GeneProduct
EPHA6GeneProduct
EPHB1GeneProduct
EPHB2GeneProduct
EPHB3GeneProduct
EPHB4GeneProduct
EPHB5GeneProduct
EPHB6GeneProduct
ERBB2GeneProduct
ERBB3GeneProduct
ERBB4GeneProduct
FGFR1GeneProduct
FGFR2GeneProduct
FGFR3GeneProduct
FGFR4GeneProduct
FLT3LGeneProduct
IGFRGeneProduct
INSRGeneProduct
KITGeneProduct
LTKGeneProduct
M-CSFRGeneProduct
METGeneProduct
MTORGeneProductENSG00000198793 (Ensembl)
MUSKGeneProduct
PDGFRAGeneProduct
PDGFRBGeneProduct
PI3KGeneProduct2.7.1.137 (Enzyme Nomenclature)
RETGeneProduct
RONGeneProduct
ROR1GeneProduct
ROR2GeneProduct
ROSGeneProduct
RYKGeneProduct
Receptor

tyrosine

kinase		GeneProduct2.7.10.1 (Enzyme Nomenclature)
TEKGeneProduct
TIEGeneProduct
TRKAGeneProduct
TRKBGeneProduct
TRKCGeneProduct
VEGFR1GeneProduct
VEGFR2GeneProduct
VEGFR3GeneProduct

Annotated Interactions

No annotated interactions

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