Hypothesized pathways in pathogenesis of cardiovascular disease (Homo sapiens)
From WikiPathways
Description
The pathways hypothesized to be involved in cardiovascular diseases begin with LTBPs and fibrillins activating a TGFBR complex. The complex can begin the canonical TGFB pathway involving SMAD proteins that target gene expression for proteins involved in endocardial and epicardial EMT, neural crest migration, ECM remodeling, cell differentiation, development and maintenance of cardiovascular structure and function. The non-canonical TGFB pathway involves the calcium-calneurin signaling pathway that also affects those functions. The TGFBR complex also activates SHCA and Tak1, which promote the function of a complex (ERK1/2, JNK1, and p38) to regulate the previously mentioned cell functions and influence the development of cardiovascular diseases. These diseases are additionally influenced by a signaling pathway involving the activation of TGFB ligands, receptors, activators, and effectors by ANG2/AT1/2R complex. This pathway is based on figure 1 from Doetschman et al.
Quality Tags
Ontology Terms
Bibliography
- Doetschman T, Barnett JV, Runyan RB, Camenisch TD, Heimark RL, Granzier HL, Conway SJ, Azhar M; ''Transforming growth factor beta signaling in adult cardiovascular diseases and repair.''; Cell Tissue Res, 2012 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AGTR1 | GeneProduct | ENSG00000144891 (Ensembl) | Identifier Not Found |
ANG2 | GeneProduct | ENSG00000091879 (Ensembl) | |
Aortic aneurysm | Q616003 (Wikidata) | ||
Atherosclerosis | Q12252367 (Wikidata) | ||
CTGF | GeneProduct | ENSG00000118523 (Ensembl) | |
Calcium calneurin pathway | Pathway | ||
Cardiomyopathy | Q847583 (Wikidata) | ||
Cell differentiation | Q210861 (Wikidata) | ||
Development and maintenance
of cardiovascular structure and function | |||
ECM remodeling | |||
ENG | GeneProduct | ENSG00000106991 (Ensembl) | |
Endocardial and epicardial EMT | Q14883191 (Wikidata) | ||
FBN1 | GeneProduct | ENSG00000166147 (Ensembl) | Firbrillins Not Specified |
FBN2 | GeneProduct | ENSG00000138829 (Ensembl) | Firbrillins Not Specified |
FBN3 | GeneProduct | ENSG00000142449 (Ensembl) | Firbrillins Not Specified |
FLNA | GeneProduct | ENSG00000196924 (Ensembl) | |
Heart valve disease | Q1130519 (Wikidata) | ||
Hypertension | Q41861 (Wikidata) | ||
Kawasaki disease | Q265936 (Wikidata) | ||
LTBP1 | GeneProduct | ENSG00000049323 (Ensembl) | LTBP Not Specified |
LTBP2 | GeneProduct | ENSG00000119681 (Ensembl) | LTBP Not Specified |
MAPK14 | GeneProduct | ENSG00000112062 (Ensembl) | |
MAPK1 | GeneProduct | ENSG00000100030 (Ensembl) | |
MAPK3 | GeneProduct | ENSG00000102882 (Ensembl) | |
MAPK8 | GeneProduct | ENSG00000107643 (Ensembl) | |
NR2C2 | GeneProduct | ENSG00000177463 (Ensembl) | |
Neural crest migration | GO:0001755 (Other) | ||
POSTN | GeneProduct | ENSG00000133110 (Ensembl) | |
RUNX2 | GeneProduct | ENSG00000124813 (Ensembl) | |
SERPINE1 | GeneProduct | ENSG00000106366 (Ensembl) | |
SHC1 | GeneProduct | ENSG00000160691 (Ensembl) | |
SMAD2 | GeneProduct | ENSG00000175387 (Ensembl) | |
SMAD3 | GeneProduct | ENSG00000166949 (Ensembl) | |
SMAD4 | GeneProduct | ENSG00000141646 (Ensembl) | |
TGFBR1 | GeneProduct | ENSG00000106799 (Ensembl) | |
TGFBR2 | GeneProduct | ENSG00000163513 (Ensembl) | |
TGFBR3 | GeneProduct | ENSG00000069702 (Ensembl) |
Annotated Interactions
No annotated interactions