Serotonin and anxiety (Homo sapiens)

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5443de Novo synthesisANXIETYDissociationArcpositive allosteric modulationMiscellaneous genespossibly involvedCHRONICSTRESSE-boxNucleus142TRPV1Ca2+DOCeEF2HTR1APPP3CAPOMCARCHTR2CCRHFOSFMR1eEF2KPLCD4THDOCGABRA1ADRA1APRKCBeEF2KKetanserinGRM1eEF2-PCAMK2BARCCa2+Ca2+PLEKHTR2A2, 645, 635265GRM1eEF2-PARC4


Description

Benekareddy et al observed the phenomenon that rats who were maternally separated show increased levels of induced anxiety-related behaviour during adulthood. Type 2 serotonin receptors have been implicated in anxiety related behaviour and may be suitable targets for reducing anxiety response. Benekareddy et al report that treatment with ketanserin (a serotonergic antagonist) during postnatal life blocked the long-lasting effects of maternal separation on anxiety behavior in the open field test and the elevated plus maze. Immediate Early Genes such as Arc have been found to be significantly affected in expression (Benekareddy et al). The downstream and upstream gene products of Arc were partly elucidated and presented in a pathway. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Comments

 
Note that part of this pathway is based on results obtained from research done in rattus norvegicus.
HomologyMapper 
This pathway was inferred from Mus musculus pathway "Serotonin and anxiety", WP2141 revision 89967, with a 80.0% conversion rate.

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Ontology Terms

 

Bibliography

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  1. Reddy DS; ''Physiological role of adrenal deoxycorticosterone-derived neuroactive steroids in stress-sensitive conditions.''; Neuroscience, 2006 PubMed Europe PMC Scholia
  2. Jensen T, Edwards JG; ''Calcineurin is required for TRPV1-induced long-term depression of hippocampal interneurons.''; Neurosci Lett, 2012 PubMed Europe PMC Scholia
  3. van der Starre PJ, Reneman RS; ''The alpha-adrenergic receptor blocking effect of ketanserin and the interaction between alpha-adrenergic and S2-serotonergic receptor blockade.''; J Cardiovasc Pharmacol, 1988 PubMed Europe PMC Scholia
  4. Bramham CR, Worley PF, Moore MJ, Guzowski JF; ''The immediate early gene arc/arg3.1: regulation, mechanisms, and function.''; J Neurosci, 2008 PubMed Europe PMC Scholia
  5. Benekareddy M, Vadodaria KC, Nair AR, Vaidya VA; ''Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress.''; Biol Psychiatry, 2011 PubMed Europe PMC Scholia
  6. Shuttleworth TJ, Thompson JL, Mignen O; ''ARC channels: a novel pathway for receptor-activated calcium entry.''; Physiology (Bethesda), 2004 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129060view01:51, 10 March 2024EweitzOntology Term : 'PW:0000319' removed !
129059view01:51, 10 March 2024EweitzOntology Term : 'PW:0000854' removed !
129058view01:51, 10 March 2024EweitzOntology Term : 'CL:0000850' removed !
106483view19:48, 3 September 2019KhanspersModified description
105813view22:55, 15 August 2019KhanspersModified description
91925view04:57, 6 April 2017Khanspersremoved old comment
90856view20:01, 14 December 2016KhanspersOntology Term : 'calcium/calmodulin dependent kinase 1 signaling pathway' added !
90855view20:01, 14 December 2016KhanspersOntology Term : 'altered calcineurin signaling pathway' added !
90854view20:01, 14 December 2016KhanspersOntology Term : 'serotonin signaling pathway' added !
90853view20:00, 14 December 2016KhanspersOntology Term : 'anxiety disorder' added !
90852view20:00, 14 December 2016KhanspersOntology Term : 'serotonergic neuron' added !
90851view20:00, 14 December 2016KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADRA1AGeneProductENSG00000120907 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000045875
ARCGeneProductENSG00000198576 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022602
CAMK2BGeneProductENSG00000058404 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000057897
CRHGeneProductENSG00000147571 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000049796
Ca2+ MetaboliteCHEBI:29108 (ChEBI)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
DOCMetabolite6166 (PubChem-compound)
FMR1GeneProductENSG00000102081 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000838
FOSGeneProductENSG00000170345 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021250
GABRA1GeneProductENSG00000022355 (Ensembl)
  • GABA a receptor
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000010803
GRM1GeneProductENSG00000152822 (Ensembl)
  • G-protein-coupled phosphatidylinositol-calcium second messenger system
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000019828
HTR1AGeneProductENSG00000178394 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021721
HTR2AGeneProductENSG00000102468 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034997
HTR2CGeneProductENSG00000147246 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000041380
KetanserinMetabolite3822 (PubChem-compound)
PLCD4GeneProductENSG00000115556 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026173
PLEKGeneProductENSG00000115956 (Ensembl)
  • pleckstrin
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020120
POMCGeneProductENSG00000115138 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020660
PPP3CAGeneProductENSG00000138814 (Ensembl)
  • calcineurin
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028161
PRKCBGeneProductENSG00000166501 (Ensembl)
  • Protein kinase C
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000052889
THDOCMetabolite91475 (PubChem-compound)
TRPV1GeneProductENSG00000196689 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000005952
eEF2GeneProduct
eEF2-PGeneProduct
eEF2KGeneProductPhosphorylates eEF2

Annotated Interactions

No annotated interactions
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