mRNA vaccine activation of dendritic cell and induction of IFN-1 (Homo sapiens)

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1111111111Dendritic cellCD8+ T cellNucleusLipid coatCD4+ T cellEndosomemRNA vaccineSpike ProteinS peptide presentationISRENF-kBT cell receptorSARS-CoV 2 mRNACellular immunityRIG-I (DDX58)Humoral immunityTLR3Proinflammatory cytokine genesMAVSType 1 IFNsProinflammatory cytokinesIRF-7IRF3MDA5IFN-1 receptorSARS-CoV 2 mRNATLR7TLR8SARS-CoV 2 mRNAType 1 IFNsS peptide presentationT cell receptorIFN-1 receptorType 1 IFNs


Description

After uptake, mRNA is translated into spike protein and presented as cell-surface MHC-bound peptides to CD4+ and CD8+ T cells. Cytosolic sensing of RNA by RIG-I and MDA5 plus TLR binding within endosomes leads to activation of IFN regulatory factor 3/7 (IRF3/7) and nuclear factor κB (NF-κB), which bind to DNA inducing gene transcription, and production of IFN-I and proinflammatory cytokines, respectively

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Bibliography

  1. Sprent J, King C; ''COVID-19 vaccine side effects: The positives about feeling bad.''; Sci Immunol, 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129216view02:03, 16 March 2024EweitzOntology Term : 'COVID-19' added !
129215view01:45, 16 March 2024EweitzOntology Term : 'CD8-positive, alpha-beta T cell' added !
129214view01:45, 16 March 2024EweitzOntology Term : 'CD4-positive, alpha-beta T cell' added !
129213view01:42, 16 March 2024EweitzOntology Term : 'dendritic cell' added !
129107view20:47, 11 March 2024AlexanderPicodebugging
129106view20:45, 11 March 2024AlexanderPicoOntology Term : 'disease pathway' added !
129105view20:44, 11 March 2024AlexanderPicoOntology Term : 'PW:0000013' removed !
129104view20:44, 11 March 2024AlexanderPicomanually fixed ontology encoding
129099view06:27, 11 March 2024EgonwOntology Term : 'disease pathway' added !
122433view11:35, 5 April 2022EweitzModified title
121329view09:44, 15 February 2022NhungPIncrease node label size
121328view09:40, 15 February 2022NhungPNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Cellular immunity
Humoral immunity
IFN-1 receptorProtein
IRF-7ProteinQ92985 (Uniprot-TrEMBL)
IRF3ProteinQ14653 (Uniprot-TrEMBL)
ISRE
MAVSProteinQ7Z434 (Uniprot-TrEMBL)
MDA5ProteinQ9BYX4 (Uniprot-TrEMBL)
NF-kBProteinQ9Y6Q6 (Uniprot-TrEMBL)
Proinflammatory cytokine genes
Proinflammatory cytokinesGeneProduct
RIG-I (DDX58)ProteinO95786 (Uniprot-TrEMBL)
S peptide presentationProteinQ95460 (Uniprot-TrEMBL)
SARS-CoV 2 mRNARna
Spike ProteinProteinP0DTC2 (Uniprot-TrEMBL)
T cell receptorProteinP01848 (Uniprot-TrEMBL)
TLR3ProteinO15455 (Uniprot-TrEMBL)
TLR7ProteinQ9NYK1 (Uniprot-TrEMBL)
TLR8ProteinQ9NR97 (Uniprot-TrEMBL)
Type 1 IFNsGeneProduct

Annotated Interactions

No annotated interactions

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