GLP-1 in pancreatic islet cells (Homo sapiens)

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Pancreatic islet?Alpha cellBeta cellMetabolic stressGLP-1InsulinGlucoseGLP1RGCGIL6IL6RSLC2A1Systematic inflammationExerciseHyperglycemiaExerciseObesityDiabetesSLC2A2INSGlucoseProliferation


Description

Factors in GLP-1 production in pancreatic alpha cells, and the hypothetical function of resulting GLP-1 in pancreatic beta cells. Based on Figure 3 in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190119.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Davis EM, Sandoval DA; ''Glucagon-like peptide-1: Actions and influence on pancreatic hormone function''; Comprehensive Physiology, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129190view10:04, 15 March 2024EgonwUpdated the Wikidata identifiers
129165view22:03, 13 March 2024EweitzMore beta interiorly
129162view12:00, 13 March 2024EweitzEconomize layout
129157view02:26, 13 March 2024EweitzModified description
129156view02:24, 13 March 2024EweitzAdd literature reference
129155view02:15, 13 March 2024EweitzIdentify remaining nodes
129154view01:59, 13 March 2024EweitzSoften inset frames
129153view01:54, 13 March 2024EweitzEconomize layout
129152view01:46, 13 March 2024EweitzPolish graphics
129151view01:24, 13 March 2024EweitzUpgrade process and disease nodes
129150view01:08, 13 March 2024EweitzOntology Term : 'type B pancreatic cell' added !
129149view01:08, 13 March 2024EweitzOntology Term : 'insulin secreting cell' added !
129148view01:07, 13 March 2024EweitzOntology Term : 'CL:0000169' removed !
129147view01:07, 13 March 2024EweitzOntology Term : 'facilitative sugar transporter mediated glucose transport pathway' added !
129146view01:04, 13 March 2024EweitzOntology Term : 'insulin secretion pathway' added !
129145view01:03, 13 March 2024EweitzOntology Term : 'signaling pathway' added !
129144view01:02, 13 March 2024EweitzOntology Term : 'type B pancreatic cell' added !
129143view01:02, 13 March 2024EweitzOntology Term : 'pancreatic A cell' added !
129142view01:01, 13 March 2024EweitzOntology Term : 'glucagon-like peptide-1 biosynthetic pathway' added !
129141view23:45, 12 March 2024EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Diabetes
Exercise
GCGGeneProduct
GLP-1Protein
GLP1RGeneProduct
GlucoseMetabolite
Hyperglycemia
IL6GeneProduct
IL6RGeneProduct
INSGeneProduct
InsulinProtein
Metabolic stress
Obesity
Proliferation
SLC2A1GeneProduct
SLC2A2GeneProduct
Systematic inflammation

Annotated Interactions

No annotated interactions

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