Estrogen signaling (Homo sapiens)

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1-3IKK complexLegendNucleusInhibitionGene expression(Cyc D, IGFR1 etc.)Genomic function of ER (slow)ActivationGene expression(pS2, Complement 3 etc.)MitochondrionNon-genomic function of ER (fast)MAPKsTranslocationCell proliferation and progressionMTOR signaling, etc.Gene expression(anti-apoptotic and proliferation)C-FOSSP1EREEstradiolER-AF1ELKERK 1/2ERER-AF2EstradiolGPR30c-JunPI3KEstradiolGrowth factorsNFKBNon-EREBCL2 apoptotic switchGFRsGNGT1Cyclic AMPGNB1PKB/AktCREBMAPKKKJNKsERGSAp38MAPKKPKACANFKBCREBCHUKERTFIKBKBIKBKG


Description

Estrogen receptor refers to a group of receptors which are activated by the hormone 17-beta-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Bibliography

  1. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  2. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  3. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129716view01:32, 22 May 2024EweitzModified title
128693view21:08, 19 February 2024EweitzEconomize layout
128689view17:28, 19 February 2024EweitzUntangle interaction, simplify line type, economize layout
128688view17:20, 19 February 2024EweitzUpgrade mitochondrion, economize layout
128687view17:12, 19 February 2024EweitzEconomize layout
128686view16:57, 19 February 2024EweitzStraighten remaining lines, economize layout, standardize case
128685view16:14, 19 February 2024EweitzSimplify interaction line types
128684view16:08, 19 February 2024EweitzEconomize layout
126218view15:04, 16 April 2023EgonwLicense is CCZero
109450view10:10, 18 March 2020L DupuisConverted interactions to graphical lines in legend
106408view21:55, 28 August 2019KhanspersModified description
106173view12:07, 16 August 2019MaintBotHMDB identifier normalization
105588view04:44, 10 August 2019KhanspersModified description
78491view10:28, 7 January 2015MaintBotadded missing graphIds
77341view19:19, 22 August 2014AlexanderPicoModified description
77340view19:18, 22 August 2014AlexanderPicoLinked refs to pathway element
72117view23:15, 24 October 2013AlexanderPicoReplaced IKK node with actual complex of individual nodes
63186view20:45, 8 May 2013MaintBotUpdating gpml version
59090view22:08, 21 February 2013MaintBotUpdated Ensembl data source
48214view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45247view18:33, 7 October 2011AlexanderPicoOntology Term : 'estrogen signaling pathway' added !
41039view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
39752view06:49, 17 January 2011AlexanderPico
38812view08:50, 24 September 2010Jildaunucleus
34842view09:12, 27 January 2010Vtriver6Specify description
34841view09:10, 27 January 2010Vtriver6Specify description
34840view09:09, 27 January 2010Vtriver6Specify description
34839view09:06, 27 January 2010Vtriver6ER signaling
34838view07:51, 27 January 2010Vtriver6Periodical save, work in progress
33422view14:53, 30 November 2009MaintBotRemoved group label
29739view22:35, 1 June 2009KhanspersModified categories
29675view11:39, 26 May 2009LauravanzonSpecify description
29593view11:18, 20 May 2009LauravanzonSpecify description
29589view08:39, 19 May 2009LauravanzonSpecify description
29588view08:38, 19 May 2009LauravanzonSpecify description
29587view08:32, 19 May 2009LauravanzonModified description
29586view08:31, 19 May 2009LauravanzonSpecify description
29585view08:24, 19 May 2009LauravanzonSpecify description
29584view08:20, 19 May 2009LauravanzonPeriodical save, work in progress
29582view07:29, 19 May 2009LauravanzonSpecify description
29581view07:19, 19 May 2009LauravanzonSpecify description
29580view11:21, 18 May 2009LauravanzonSpecify description
29579view11:18, 18 May 2009LauravanzonSpecify description
29578view11:14, 18 May 2009LauravanzonPeriodical save, work in progress
29577view10:49, 18 May 2009Lauravanzon
29576view10:41, 18 May 2009LauravanzonPeriodical save, work in progress
29575view10:31, 18 May 2009LauravanzonPeriodical save, work in progress
29574view10:21, 18 May 2009LauravanzonPeriodical save, work in progress
29573view10:11, 18 May 2009LauravanzonPeriodical save, work in progress
29572view10:00, 18 May 2009LauravanzonPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BCL2 apoptotic switchGeneProduct596 (Entrez Gene)
C-FOSGeneProduct2353 (Entrez Gene)
CHUKGeneProduct1147 (Entrez Gene)
CREBGeneProduct1385 (Entrez Gene)
Cyclic AMPMetaboliteHMDB0000058 (HMDB)
ELKGeneProduct2002 (Entrez Gene)
ER-AF1GeneProduct2099 (Entrez Gene)
ER-AF2GeneProduct2099 (Entrez Gene)
ERGeneProduct2099 (Entrez Gene)
EREGeneProduct2099 (Entrez Gene)
ERK 1/2GeneProductENSG00000100030 (Ensembl)
EstradiolMetaboliteHMDB0000151 (HMDB)
GFRsGeneProduct2099 (Entrez Gene)
GNB1GeneProduct2782 (Entrez Gene)
GNGT1GeneProduct2792 (Entrez Gene)
GPR30GeneProduct2852 (Entrez Gene)
GSAGeneProduct2778 (Entrez Gene)
Growth factorsMetaboliteHMDB0000151 (HMDB)
IKBKBGeneProduct3551 (Entrez Gene)
IKBKGGeneProduct8517 (Entrez Gene)
JNKsGeneProduct5601 (Entrez Gene)
MAPKKGeneProductENSG00000169032 (Ensembl)
MAPKKKGeneProduct673 (Entrez Gene)
NFKBGeneProduct4790 (Entrez Gene)
Non-EREGeneProduct2099 (Entrez Gene)
PI3KGeneProduct5290 (Entrez Gene)
PKACAGeneProduct5566 (Entrez Gene)
PKB/AktGeneProduct207 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
TFGeneProduct2099 (Entrez Gene)
c-JunGeneProduct3725 (Entrez Gene)
p38GeneProduct1432 (Entrez Gene)

Annotated Interactions

No annotated interactions

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