Wnt signaling and pluripotency (Homo sapiens)
From WikiPathways
Description
This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal.
A central organizing theme of this pathway are known drug targets that promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.Quality Tags
Ontology Terms
Bibliography
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- ''Kegg version of this pathway''; http://www.genome.jp/kegg/pathway/hsa/hsa04310.html,
- Yi F, Pereira L, Merrill BJ; ''Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal.''; Stem Cells, 2008 PubMed Europe PMC Scholia
- Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed Europe PMC Scholia
- Sato N, Brivanlou AH; ''Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor.''; Methods Mol Biol, 2006 PubMed Europe PMC Scholia
- Zhang X, Zhang J, Wang T, Esteban MA, Pei D; ''''; , PubMed Europe PMC Scholia
- Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M; ''Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
26S Proteasome Degradation | Pathway | WP183 (WikiPathways) | |
APC | GeneProduct | 324 (Entrez Gene) | |
AXIN1 | GeneProduct | 8312 (Entrez Gene) | |
AXIN2 | GeneProduct | 8313 (Entrez Gene) | |
Apoptosis | Pathway | WP254 (WikiPathways) | |
BIO | Metabolite | 5287844 (PubChem-compound) | |
CBP | GeneProduct | 1387 (Entrez Gene) | |
CCND1 | GeneProduct | 595 (Entrez Gene) | |
CCND2 | GeneProduct | 894 (Entrez Gene) | |
CCND3 | GeneProduct | 896 (Entrez Gene) | |
CD44 | GeneProduct | 960 (Entrez Gene) | |
CSNK1E | GeneProduct | 1454 (Entrez Gene) | |
CTBP1 | GeneProduct | 1487 (Entrez Gene) | |
CTBP2 | GeneProduct | 1488 (Entrez Gene) | |
CTNNB1 | GeneProduct | 1499 (Entrez Gene) | |
CTNND1 | GeneProduct | 1500 (Entrez Gene) | |
DVL1 | GeneProduct | 1855 (Entrez Gene) | |
DVL2 | GeneProduct | 1856 (Entrez Gene) | |
DVL3 | GeneProduct | 1857 (Entrez Gene) | |
ESRRB | GeneProduct | 2103 (Entrez Gene) | |
FBXW2 | GeneProduct | 26190 (Entrez Gene) | |
FOSL1 | GeneProduct | 8061 (Entrez Gene) | |
FOXD3 | GeneProduct | ENSG00000187140 (Ensembl) | |
FRAT1 | GeneProduct | 10023 (Entrez Gene) | |
FZD10 | GeneProduct | ENSG00000111432 (Ensembl) | |
FZD1 | GeneProduct | 8321 (Entrez Gene) | |
FZD2 | GeneProduct | 2535 (Entrez Gene) | |
FZD3 | GeneProduct | 7976 (Entrez Gene) | |
FZD4 | GeneProduct | 8322 (Entrez Gene) | |
FZD5 | GeneProduct | 7855 (Entrez Gene) | |
FZD6 | GeneProduct | 8323 (Entrez Gene) | |
FZD7 | GeneProduct | 8324 (Entrez Gene) | |
FZD8 | GeneProduct | 8325 (Entrez Gene) | |
FZD9 | GeneProduct | 8326 (Entrez Gene) | |
GSK3B | GeneProduct | 2932 (Entrez Gene) | |
Groucho | GeneProduct | ||
IQ-1 | Metabolite | 331001-62-8 (CAS) | |
JUN | GeneProduct | 3725 (Entrez Gene) | |
LDLR | GeneProduct | 3949 (Entrez Gene) | |
LEF1 | GeneProduct | 51176 (Entrez Gene) | |
LRP5 | GeneProduct | 4041 (Entrez Gene) | |
LRP6 | GeneProduct | 4040 (Entrez Gene) | |
LRRK2-mut | GeneProduct | 120892 (Entrez Gene) | |
MAP2K4 | GeneProduct | 6416 (Entrez Gene) | |
MAP3K7 | GeneProduct | 6885 (Entrez Gene) | |
MAPK10 | GeneProduct | 5602 (Entrez Gene) | |
MAPK9 | GeneProduct | 5601 (Entrez Gene) | |
MMP7 | GeneProduct | 4316 (Entrez Gene) | |
MYC | GeneProduct | 4609 (Entrez Gene) | |
NANOG | GeneProduct | 79923 (Entrez Gene) | |
NFYA | GeneProduct | ENSG00000001167 (Ensembl) | |
NKD1 | GeneProduct | 85407 (Entrez Gene) | |
NKD2 | GeneProduct | 85409 (Entrez Gene) | |
NLK | GeneProduct | 51701 (Entrez Gene) | |
P300 | GeneProduct | 2033 (Entrez Gene) | |
PAFAH1B1 | GeneProduct | 5048 (Entrez Gene) | |
PLAU | GeneProduct | 5328 (Entrez Gene) | |
POU5F1 | GeneProduct | 5460 (Entrez Gene) | |
PPARD | GeneProduct | 5467 (Entrez Gene) | |
PPM1J | GeneProduct | ENSG00000155367 (Ensembl) | |
PPP2CA | GeneProduct | 5515 (Entrez Gene) | |
PPP2CB | GeneProduct | 5516 (Entrez Gene) | |
PPP2R1A | GeneProduct | 5518 (Entrez Gene) | |
PPP2R1B | GeneProduct | 5519 (Entrez Gene) | |
PPP2R2A | GeneProduct | 5520 (Entrez Gene) | |
PPP2R2B | GeneProduct | 5521 (Entrez Gene) | |
PPP2R2C | GeneProduct | 5522 (Entrez Gene) | |
PPP2R3A | GeneProduct | 5523 (Entrez Gene) | |
PPP2R3B | GeneProduct | 28227 (Entrez Gene) | |
PPP2R4 | GeneProduct | 5524 (Entrez Gene) | |
PPP2R5C | GeneProduct | 5527 (Entrez Gene) | |
PPP2R5E | GeneProduct | 5529 (Entrez Gene) | |
PRKCA | GeneProduct | 5578 (Entrez Gene) | |
PRKCB1 | GeneProduct | 5579 (Entrez Gene) | |
PRKCD | GeneProduct | 5580 (Entrez Gene) | |
PRKCE | GeneProduct | 5581 (Entrez Gene) | |
PRKCH | GeneProduct | 5583 (Entrez Gene) | |
PRKCI | GeneProduct | 5584 (Entrez Gene) | |
PRKCQ | GeneProduct | 5588 (Entrez Gene) | |
PRKCZ | GeneProduct | 5590 (Entrez Gene) | |
PRKD1 | GeneProduct | 5587 (Entrez Gene) | |
Prkcc | GeneProduct | 5582 (Entrez Gene) | |
RACGAP1 | GeneProduct | 29127 (Entrez Gene) | |
RHOA | GeneProduct | 387 (Entrez Gene) | |
SOX2 | GeneProduct | 6657 (Entrez Gene) | |
TCF7 | GeneProduct | ENSG00000081059 (Ensembl) | |
TCF7L1 | GeneProduct | 83439 (Entrez Gene) | |
TCF7L2 | GeneProduct | ENSG00000148737 (Ensembl) | |
TP53 | GeneProduct | 7157 (Entrez Gene) | |
WNT10A | GeneProduct | 80326 (Entrez Gene) | |
WNT10B | GeneProduct | 7480 (Entrez Gene) | |
WNT11 | GeneProduct | 7481 (Entrez Gene) | Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629 |
WNT16 | GeneProduct | 51384 (Entrez Gene) | |
WNT1 | GeneProduct | 7471 (Entrez Gene) | |
WNT2 | GeneProduct | 7472 (Entrez Gene) | |
WNT2B | GeneProduct | 7482 (Entrez Gene) | |
WNT3 | GeneProduct | 7473 (Entrez Gene) | |
WNT3A | GeneProduct | 89780 (Entrez Gene) | |
WNT4 | GeneProduct | 54361 (Entrez Gene) | |
WNT5A | GeneProduct | 7474 (Entrez Gene) | |
WNT5B | GeneProduct | 81029 (Entrez Gene) | |
WNT6 | GeneProduct | 7475 (Entrez Gene) | |
WNT7A | GeneProduct | 7476 (Entrez Gene) | |
WNT7B | GeneProduct | 7477 (Entrez Gene) | |
WNT9B | GeneProduct | 7484 (Entrez Gene) | |
ZBTB33 | GeneProduct | 10009 (Entrez Gene) |
Annotated Interactions
No annotated interactions