Artemisinin inhibition of uveal melanoma (Homo sapiens)

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Revision as of 21:17, 22 May 2024 by Eweitz (Talk | contribs)
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1GrowthMitochondrialpotentialIncreaseLegendReceptor tyrosine kinaseAKTApoptosisArtemisininPI3KMTORMigrationInvasionDecreaseAKTAKT1AKT2AKT3PIK3CAPIK3CBPIK3CGPIK3CDClass 1 catalyticPIK3R1PIK3R2PIK3R3PIK3R4Class 1 regulatoryPIK3R4PIK3R6PIK3C2APIK3C2BPIK3C2GClass 2PIK3C2AClass 3PI3K


Description

Farhan et al. (2021) note: "By acting in PI3K/AKT/mTOR, a pathway with recognized importance in cancer, artemisinin was shown to be able to impair the migration, invasion, and proliferation of UM cells." Triangles indicate an increase or decrease in the adjacent entity. This pathway diagram was derived from https://pfocr.wikipathways.org/figures/PMC8684509__OMCL2021-9911537.012.html.

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Bibliography

  1. Farhan M, Silva M, Xingan X, Zhou Z, Zheng W; ''Artemisinin Inhibits the Migration and Invasion in Uveal Melanoma via Inhibition of the PI3K/AKT/mTOR Signaling Pathway.''; Oxid Med Cell Longev, 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129817view22:22, 22 May 2024EweitzEconomize layout
129816view22:01, 22 May 2024EweitzExtract 14 genes for PI3K family to separate pathway
129812view21:42, 22 May 2024EweitzExtract 40 genes in RTK family from legend to annotated list pathway
129805view21:17, 22 May 2024EweitzTailor node dimensions
128501view13:41, 10 February 2024EweitzCenter group labels in legend
128500view13:23, 10 February 2024EweitzShow PI3K family by class in legend
128490view23:01, 6 February 2024EweitzLegend AKT members, refine AKT node type
128489view21:54, 6 February 2024EweitzLeft-flush label and nodes for inner groups
128488view21:47, 6 February 2024EweitzApply stack horizontal center to RTK members
128487view21:43, 6 February 2024EweitzComplete raw nodes for RTK family genes, by class
128486view21:17, 6 February 2024EweitzDraft RTK gene family members
128485view21:15, 6 February 2024EweitzReverted to version '23:58, 5 February 2024' by Eweitz
128484view21:14, 6 February 2024EweitzReverted to version '23:56, 5 February 2024' by Eweitz
128482view23:58, 5 February 2024EweitzModified description
128481view23:56, 5 February 2024EweitzPer feedback: connect RTK and PI3K, delegend AKT, legend triangles (https://github.com/wikipathways/wikipathways-help/issues/104)
128352view13:39, 2 February 2024EweitzAdd mitochondrion graphic
128351view13:35, 2 February 2024EweitzRefine identifiers, add legend, enrich level triangles
128348view04:59, 2 February 2024EweitzOntology Term : 'drug pathway' added !
128347view04:58, 2 February 2024EweitzOntology Term : 'melanoma' added !
128346view04:58, 2 February 2024EweitzOntology Term : 'uveal cancer' added !
128345view04:57, 2 February 2024EweitzOntology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
128344view04:33, 2 February 2024EweitzIdentify nodes
128343view03:26, 2 February 2024EweitzModified description
128342view03:25, 2 February 2024EweitzNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
AKTQ423650 (Wikidata)
ApoptosisPathwayWP254 (WikiPathways)
ArtemisininMetabolite223316 (ChEBI)
MTORGeneProductENSG00000198793 (Ensembl)
PI3KGeneProduct2.7.1.137 (Enzyme Nomenclature)
PIK3C2AGeneProduct
PIK3C2BGeneProduct
PIK3C2GGeneProduct
PIK3CAGeneProduct
PIK3CBGeneProduct
PIK3CDGeneProduct
PIK3CGGeneProduct
PIK3R1GeneProduct
PIK3R2GeneProduct
PIK3R3GeneProduct
PIK3R4GeneProduct
PIK3R6GeneProduct
Receptor

tyrosine

kinase		GeneProductWP5471 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5441"
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