Cytokine-cytokine receptor interaction (Homo sapiens)

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1-17EDA-A1Chemokines?CCL1CCR8CCL25CCR9CCL19ACKR4CCR7CCL21CC subfamilyCCL3L1CCL4CCL4L1CCL4L2CCL5CCL3CCL8CCL15CCL13CCL6CCL7CCL2CCL12CCL11CCL24CCL26CCL27CCL28CCL18CCL20CCR4CCR5CCR3CCR11CCR2CCR1CCR3CCR11CCR2CCR3CCR10CCR6CCL17CCL22CCL9CCL14CCL16CCL23CXC subfamilyCXCL1CXCL5CXCL6CXCL8CXCL2CXCL3CXCL7CXCL4CXCL4L1CXCL9CXCL10CXCL11CXCL13CXCL12CXCL16CXCL14CXCL15CXCL17XCL1XCL2CX3CL1CXCR1CXCR2CXCL3CXCR5CXCR4CXCR7CXCR6???XCR1CX3CR1C subfamilyCX3C subfamilyClass I helical cytokinesIL2Gamma-chain utilizingIL4IL7IL9IL15IL21TSLPIL3IL5CSF2IL4IL13EPOGH1GH2PRLTPOCSF3LEPIL2RAIL2RBIL2RGIL2RAIL2RBIL4RIL2RGIL7RIL2RGIL9RIL2RGIL15RAIL2RBIL2RGIL21RIL2RGIL21RIL2RGIL4-likeIL3RACSF2RBIL5RACSF2RBCSF2RACSF2RBIL4RIL4RIL13RA1IL4RIL13RA2IL3RAIL13RA2EPOGHRPRLRMPLCSF3RLEPRProlactin familyIL6- / IL12-likeIL6IL6RIL6STIL11IL11RAIL6STIL12IL12RB1IL12RB2IL23AIL23RIL12RB1IL27IL27RAIL6STIL31IL31RAIL6STIL35IL12RB2IL6STCNTFRLIFRCLCF1CNTFIL6STCTFCNTFRLIFRIL6STCNTFRLIFRLIFCNTFCTFCNTFRLIFRClass II helical cytokinesIL10- / IL28-likeIL10IL10RAIL10RBIL19IL20RAIL20RBIL20IL24IL22RA1IL20RBIL22IL26IL10RBIL20RAIL22RA1IL20RBIL28BIL28AIL29IL10RBIL28RAIFNAIFNB1IFNW1IFNKIFNT1IFNGIFNAR1IFNAR2IFNGR1IFNGR2IL1AIL2AIL1R1IL1RAPIL1R2Interferon familyIL1F5IL1F6IL1F8IL1F9IL1F10IL1RNIL1-like cytokinesIL1RL2IL18RAPIL1F7IL18IL18R1IL18RAPIL33ST2IL1RAPIL17AIL17FIL17RAIL17RCIL17RBIL17BIL17-like cytokinesIL17EIL17RAIL17RBIL17REIL17CIL17D?IL1R2IL1RNNon-classifiedIL34CSF1CSF1R?IL1RNTNFTNFR1TNFR2TNF familyLTALTBRHVEMLTBLIGHTDCR3FASLGVEGIFASDR3TRAILDR4DR5DCR1DCR2?DR6EDAEDAEDARXEDAREDA-A2NGFNGFROPGRANKLRANKTWEAKFN14CD70CD27CD30LCD30CD40LGCD40TNFSF9TNFRSF9TNFSF4TNFRSF4GITRLGITRAPRILBAFFBCMATACIBAFFRTROYRELT??TGFB1TGFB familyTGFB2TGFB3GDF15GDF2BMP10GDF10GDF11MSTNINHBAINHBBGDF1GDF3NODALGDF9INHBCINHBEAMHINHABMP3


Description

Interactions between cytokines and their receptors. Derived from KEGG, https://www.kegg.jp/entry/pathway+map04060.

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Bibliography

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  1. Lopetuso LR, Chowdhry S, Pizarro TT; ''Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.''; Front Immunol, 2013 PubMed Europe PMC Scholia
  2. Turner MD, Nedjai B, Hurst T, Pennington DJ; ''Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.''; Biochim Biophys Acta, 2014 PubMed Europe PMC Scholia
  3. Meenhuis A, Verwijmeren C, Roovers O, Touw IP; ''The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.''; Biochem J, 2011 PubMed Europe PMC Scholia
  4. Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA; ''Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases.''; J Allergy Clin Immunol, 2016 PubMed Europe PMC Scholia
  5. Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W; ''Structures and biological functions of IL-31 and IL-31 receptors.''; Cytokine Growth Factor Rev, 2008 PubMed Europe PMC Scholia
  6. Aggarwal BB; ''Signalling pathways of the TNF superfamily: a double-edged sword.''; Nat Rev Immunol, 2003 PubMed Europe PMC Scholia
  7. Boulanger MJ, Garcia KC; ''Shared cytokine signaling receptors: structural insights from the gp130 system.''; Adv Protein Chem, 2004 PubMed Europe PMC Scholia
  8. Seeger P, Musso T, Sozzani S; ''The TGF-β superfamily in dendritic cell biology.''; Cytokine Growth Factor Rev, 2015 PubMed Europe PMC Scholia
  9. Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V; ''Evolutionary divergence and functions of the human interleukin (IL) gene family.''; Hum Genomics, 2010 PubMed Europe PMC Scholia
  10. Fischer P, Hilfiker-Kleiner D; ''Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.''; Basic Res Cardiol, 2007 PubMed Europe PMC Scholia
  11. Richards CD; ''The enigmatic cytokine oncostatin m and roles in disease.''; ISRN Inflamm, 2013 PubMed Europe PMC Scholia
  12. Wakefield LM, Hill CS; ''Beyond TGFβ: roles of other TGFβ superfamily members in cancer.''; Nat Rev Cancer, 2013 PubMed Europe PMC Scholia
  13. de Weerd NA, Nguyen T; ''The interferons and their receptors--distribution and regulation.''; Immunol Cell Biol, 2012 PubMed Europe PMC Scholia
  14. Ashkenazi A; ''Targeting death and decoy receptors of the tumour-necrosis factor superfamily.''; Nat Rev Cancer, 2002 PubMed Europe PMC Scholia
  15. Allan SM, Tyrrell PJ, Rothwell NJ; ''Interleukin-1 and neuronal injury.''; Nat Rev Immunol, 2005 PubMed Europe PMC Scholia
  16. Mueller TD, Nickel J; ''Promiscuity and specificity in BMP receptor activation.''; FEBS Lett, 2012 PubMed Europe PMC Scholia
  17. Iwakura Y, Ishigame H, Saijo S, Nakae S; ''Functional specialization of interleukin-17 family members.''; Immunity, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
130884view00:21, 31 May 2024EweitzNudge to fix width render bug in site
130883view00:10, 31 May 2024EweitzGroup nodes in color
130758view03:10, 30 May 2024EweitzDecrease font size so gene name fits in node width
130755view02:55, 30 May 2024EweitzOntology Term : 'signaling pathway' added !
130754view02:55, 30 May 2024EweitzOntology Term : 'cytokine mediated signaling pathway' added !
130753view02:52, 30 May 2024EweitzFinish 2nd pass of node identification
130747view02:12, 30 May 2024EweitzFinish identifying all nodes as first pass
130743view01:45, 30 May 2024EweitzIdentify nodes in 7th column
130733view00:31, 30 May 2024EweitzIdentify nodes in 6th column
130732view00:19, 30 May 2024EweitzIdentify nodes in 5th column
130715view21:59, 29 May 2024EweitzIdentify nodes in 4th column
130656view12:01, 29 May 2024EweitzIdentify column 3 receptors
130655view11:42, 29 May 2024EweitzIdentify column 3 ligands
130605view03:32, 29 May 2024EweitzNudge height parameter to fix site-PathVisio discrepancy
130604view03:25, 29 May 2024EweitzEconomize layout
130591view01:58, 29 May 2024EweitzIdentify almost all CXC subfamily nodes
130587view01:41, 29 May 2024EweitzIdentify almost all CC subfamily nodes
130575view23:59, 28 May 2024EweitzConnect 8th column (TGFB family)
130574view23:54, 28 May 2024EweitzName, group 8th column (TGFB family)
130570view22:49, 28 May 2024EweitzDecrease text size to fit in TGFB family node width
130569view22:46, 28 May 2024EweitzEconomize layout
130561view22:01, 28 May 2024EweitzFinish 7th column (TGFB family)
130269view00:49, 28 May 2024EweitzFinish ligands in 7th column (TGFB family)
130268view22:04, 27 May 2024EweitzFinish 6th column (TNF family)
130252view18:55, 27 May 2024EweitzAdd to 6th column (TNF family)
130251view18:42, 27 May 2024EweitzAdd top of 6th column (TNF family)
130237view13:58, 27 May 2024EweitzFinish 5th column (IL17-like, non-classified)
130233view13:28, 27 May 2024EweitzAdd top of 5th column (interferon, IL1-like)
130200view03:30, 27 May 2024EweitzAdd IL6- / IL12-like cytokines (4th column)
130190view00:34, 27 May 2024EweitzUpdate 3rd column
130142view13:02, 26 May 2024EweitzName, group most gamma-chain cytokines (3rd column)
130099view11:56, 25 May 2024EweitzConnect, group, head 2nd column
130065view02:05, 25 May 2024EweitzAdd nodes, names for CXC subfamily
130056view00:42, 25 May 2024EweitzFinish naming CC receptors, setting CC ligand-receptor interactions
129934view02:30, 24 May 2024EweitzName, group remaining CC ligands
129931view01:59, 24 May 2024EweitzScaffold remaining CC subfamily
129920view00:23, 24 May 2024EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
?
ACKR4GeneProductENSG00000129048 (Ensembl)
AMHGeneProductENSG (Ensembl)
APRILGeneProductENSG (Ensembl)
BAFFGeneProductENSG (Ensembl)
BAFFRGeneProductENSG (Ensembl)
BCMAGeneProductENSG (Ensembl)
BMP10GeneProductENSG (Ensembl)
BMP3GeneProductENSG (Ensembl)
CCL11GeneProductENSG (Ensembl)
CCL12GeneProductENSG (Ensembl)
CCL13GeneProductENSG (Ensembl)
CCL14GeneProductENSG (Ensembl)
CCL15GeneProductENSG (Ensembl)
CCL16GeneProductENSG (Ensembl)
CCL17GeneProductENSG (Ensembl)
CCL18GeneProductENSG (Ensembl)
CCL19GeneProductENSG00000172724 (Ensembl)
CCL1GeneProductENSG00000108702 (Ensembl)
CCL20GeneProductENSG (Ensembl)
CCL21GeneProductENSG00000137077 (Ensembl)
CCL22GeneProductENSG (Ensembl)
CCL23GeneProductENSG (Ensembl)
CCL24GeneProductENSG (Ensembl)
CCL25GeneProductENSG00000131142 (Ensembl)
CCL26GeneProductENSG (Ensembl)
CCL27GeneProductENSG (Ensembl)
CCL28GeneProductENSG (Ensembl)
CCL2GeneProductENSG (Ensembl)
CCL3GeneProductENSG (Ensembl)
CCL3L1GeneProductENSG (Ensembl)
CCL4GeneProductENSG (Ensembl)
CCL4L1GeneProductENSG (Ensembl)
CCL4L2GeneProductENSG (Ensembl)
CCL5GeneProductENSG (Ensembl)
CCL6GeneProductENSG (Ensembl)
CCL7GeneProductENSG (Ensembl)
CCL8GeneProductENSG (Ensembl)
CCL9GeneProductENSG (Ensembl)
CCR10GeneProductENSG (Ensembl)
CCR11GeneProductENSG (Ensembl)
CCR1GeneProductENSG (Ensembl)
CCR2GeneProductENSG (Ensembl)
CCR3GeneProductENSG (Ensembl)
CCR4GeneProductENSG (Ensembl)
CCR5GeneProductENSG (Ensembl)
CCR6GeneProductENSG (Ensembl)
CCR7GeneProductENSG00000126353 (Ensembl)
CCR8GeneProductENSG00000179934 (Ensembl)
CCR9GeneProductENSG00000173585 (Ensembl)
CD27GeneProductENSG (Ensembl)
CD30GeneProductENSG (Ensembl)
CD30LGeneProductENSG (Ensembl)
CD40GeneProductENSG (Ensembl)
CD40LGGeneProductENSG (Ensembl)
CD70GeneProductENSG (Ensembl)
CLCF1GeneProductENSG (Ensembl)
CNTFGeneProductENSG (Ensembl)
CNTFRGeneProductENSG (Ensembl)
CSF1GeneProductENSG (Ensembl)
CSF1RGeneProductENSG (Ensembl)
CSF2GeneProductENSG (Ensembl)
CSF2RAGeneProductENSG (Ensembl)
CSF2RBGeneProductENSG (Ensembl)
CSF3GeneProductENSG (Ensembl)
CSF3RGeneProductENSG (Ensembl)
CTFGeneProductENSG (Ensembl)
CX3CL1GeneProductENSG (Ensembl)
CX3CR1GeneProductENSG (Ensembl)
CXCL10GeneProductENSG (Ensembl)
CXCL11GeneProductENSG (Ensembl)
CXCL12GeneProductENSG (Ensembl)
CXCL13GeneProductENSG (Ensembl)
CXCL14GeneProductENSG (Ensembl)
CXCL15GeneProductENSG (Ensembl)
CXCL16GeneProductENSG (Ensembl)
CXCL17GeneProductENSG (Ensembl)
CXCL1GeneProductENSG (Ensembl)
CXCL2GeneProductENSG (Ensembl)
CXCL3GeneProductENSG (Ensembl)
CXCL4GeneProductENSG (Ensembl)
CXCL4L1GeneProductENSG (Ensembl)
CXCL5GeneProductENSG (Ensembl)
CXCL6GeneProductENSG (Ensembl)
CXCL7GeneProductENSG (Ensembl)
CXCL8GeneProductENSG (Ensembl)
CXCL9GeneProductENSG (Ensembl)
CXCR1GeneProductENSG (Ensembl)
CXCR2GeneProductENSG (Ensembl)
CXCR4GeneProductENSG (Ensembl)
CXCR5GeneProductENSG (Ensembl)
CXCR6GeneProductENSG (Ensembl)
CXCR7GeneProductENSG (Ensembl)
DCR1GeneProductENSG (Ensembl)
DCR2GeneProductENSG (Ensembl)
DCR3GeneProductENSG (Ensembl)
DR3GeneProductENSG (Ensembl)
DR4GeneProductENSG (Ensembl)
DR5GeneProductENSG (Ensembl)
DR6GeneProductENSG (Ensembl)
EDA
EDAGeneProductENSG (Ensembl)
EDARGeneProductENSG (Ensembl)
EPOGeneProductENSG (Ensembl)
FASGeneProductENSG (Ensembl)
FASLGGeneProductENSG (Ensembl)
FN14GeneProductENSG (Ensembl)
GDF10GeneProductENSG (Ensembl)
GDF11GeneProductENSG (Ensembl)
GDF15GeneProductENSG (Ensembl)
GDF1GeneProductENSG (Ensembl)
GDF2GeneProductENSG (Ensembl)
GDF3GeneProductENSG (Ensembl)
GDF9GeneProductENSG (Ensembl)
GH1GeneProductENSG (Ensembl)
GH2GeneProductENSG (Ensembl)
GHRGeneProductENSG (Ensembl)
GITRGeneProductENSG (Ensembl)
GITRLGeneProductENSG (Ensembl)
HVEMGeneProductENSG (Ensembl)
IFNAGeneProductENSG (Ensembl)
IFNAR1GeneProductENSG (Ensembl)
IFNAR2GeneProductENSG (Ensembl)
IFNB1GeneProductENSG (Ensembl)
IFNGGeneProductENSG (Ensembl)
IFNGR1GeneProductENSG (Ensembl)
IFNGR2GeneProductENSG (Ensembl)
IFNKGeneProductENSG (Ensembl)
IFNT1GeneProductENSG (Ensembl)
IFNW1GeneProductENSG (Ensembl)
IL10GeneProductENSG (Ensembl)
IL10RAGeneProductENSG (Ensembl)
IL10RBGeneProductENSG (Ensembl)
IL11GeneProductENSG (Ensembl)
IL11RAGeneProductENSG (Ensembl)
IL12GeneProductENSG (Ensembl)
IL12RB1GeneProductENSG (Ensembl)
IL12RB2GeneProductENSG (Ensembl)
IL13GeneProductENSG (Ensembl)
IL13RA1GeneProductENSG (Ensembl)
IL13RA2GeneProductENSG (Ensembl)
IL15GeneProductENSG (Ensembl)
IL15RAGeneProductENSG (Ensembl)
IL17AGeneProductENSG (Ensembl)
IL17BGeneProductENSG (Ensembl)
IL17CGeneProductENSG (Ensembl)
IL17DGeneProductENSG (Ensembl)
IL17EGeneProductENSG (Ensembl)
IL17FGeneProductENSG (Ensembl)
IL17RAGeneProductENSG (Ensembl)
IL17RBGeneProductENSG (Ensembl)
IL17RCGeneProductENSG (Ensembl)
IL17REGeneProductENSG (Ensembl)
IL18GeneProductENSG (Ensembl)
IL18R1GeneProductENSG (Ensembl)
IL18RAPGeneProductENSG (Ensembl)
IL19GeneProductENSG (Ensembl)
IL1AGeneProductENSG (Ensembl)
IL1F10GeneProductENSG (Ensembl)
IL1F5GeneProductENSG (Ensembl)
IL1F6GeneProductENSG (Ensembl)
IL1F7GeneProductENSG (Ensembl)
IL1F8GeneProductENSG (Ensembl)
IL1F9GeneProductENSG (Ensembl)
IL1R1GeneProductENSG (Ensembl)
IL1R2GeneProductENSG (Ensembl)
IL1RAPGeneProductENSG (Ensembl)
IL1RL2GeneProductENSG (Ensembl)
IL1RNGeneProductENSG (Ensembl)
IL20GeneProductENSG (Ensembl)
IL20RAGeneProductENSG (Ensembl)
IL20RBGeneProductENSG (Ensembl)
IL21GeneProductENSG (Ensembl)
IL21RGeneProductENSG (Ensembl)
IL22GeneProductENSG (Ensembl)
IL22RA1GeneProductENSG (Ensembl)
IL23AGeneProductENSG (Ensembl)
IL23RGeneProductENSG (Ensembl)
IL24GeneProductENSG (Ensembl)
IL26GeneProductENSG (Ensembl)
IL27GeneProductENSG (Ensembl)
IL27RAGeneProductENSG (Ensembl)
IL28AGeneProductENSG (Ensembl)
IL28BGeneProductENSG (Ensembl)
IL28RAGeneProductENSG (Ensembl)
IL29GeneProductENSG (Ensembl)
IL2AGeneProductENSG (Ensembl)
IL2GeneProductENSG (Ensembl)
IL2RAGeneProductENSG (Ensembl)
IL2RBGeneProductENSG (Ensembl)
IL2RGGeneProductENSG (Ensembl)
IL31GeneProductENSG (Ensembl)
IL31RAGeneProductENSG (Ensembl)
IL33GeneProductENSG (Ensembl)
IL34GeneProductENSG (Ensembl)
IL35GeneProductENSG (Ensembl)
IL3GeneProductENSG (Ensembl)
IL3RAGeneProductENSG (Ensembl)
IL4GeneProductENSG (Ensembl)
IL4RGeneProductENSG (Ensembl)
IL5GeneProductENSG (Ensembl)
IL5RAGeneProductENSG (Ensembl)
IL6GeneProductENSG (Ensembl)
IL6RGeneProductENSG (Ensembl)
IL6STGeneProductENSG (Ensembl)
IL7GeneProductENSG (Ensembl)
IL7RGeneProductENSG (Ensembl)
IL9GeneProductENSG (Ensembl)
IL9RGeneProductENSG (Ensembl)
INHAGeneProductENSG (Ensembl)
INHBAGeneProductENSG (Ensembl)
INHBBGeneProductENSG (Ensembl)
INHBCGeneProductENSG (Ensembl)
INHBEGeneProductENSG (Ensembl)
LEPGeneProductENSG (Ensembl)
LEPRGeneProductENSG (Ensembl)
LIFGeneProductENSG (Ensembl)
LIFRGeneProductENSG (Ensembl)
LIGHTGeneProductENSG (Ensembl)
LTAGeneProductENSG (Ensembl)
LTBGeneProductENSG (Ensembl)
LTBRGeneProductENSG (Ensembl)
MPLGeneProductENSG (Ensembl)
MSTNGeneProductENSG (Ensembl)
NGFGeneProductENSG (Ensembl)
NGFRGeneProductENSG (Ensembl)
NODALGeneProductENSG (Ensembl)
OPGGeneProductENSG (Ensembl)
PRLGeneProductENSG (Ensembl)
PRLRGeneProductENSG (Ensembl)
RANKGeneProductENSG (Ensembl)
RANKLGeneProductENSG (Ensembl)
RELTGeneProductENSG (Ensembl)
ST2GeneProductENSG (Ensembl)
TACIGeneProductENSG (Ensembl)
TGFB1GeneProductENSG (Ensembl)
TGFB2GeneProductENSG (Ensembl)
TGFB3GeneProductENSG (Ensembl)
TNFGeneProductENSG (Ensembl)
TNFR1GeneProductENSG (Ensembl)
TNFR2GeneProductENSG (Ensembl)
TNFRSF4GeneProductENSG (Ensembl)
TNFRSF9GeneProductENSG (Ensembl)
TNFSF4GeneProductENSG (Ensembl)
TNFSF9GeneProductENSG (Ensembl)
TPOGeneProductENSG (Ensembl)
TRAILGeneProductENSG (Ensembl)
TROYGeneProductENSG (Ensembl)
TSLPGeneProductENSG (Ensembl)
TWEAKGeneProductENSG (Ensembl)
VEGIGeneProductENSG (Ensembl)
XCL1GeneProductENSG (Ensembl)
XCL2GeneProductENSG (Ensembl)
XCR1GeneProductENSG (Ensembl)
XEDARGeneProductENSG (Ensembl)

Annotated Interactions

No annotated interactions

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