Frustrated phagocytosis leading to malignant pleural mesothelioma (Homo sapiens)

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1, 2HoC: Sustaining proliferative signallingNRF2 pathwayOxidative damage response Cell cycle checkpoints Increased secretion of proinflammatory mediatorsFrustrated phagocytosisIncreased reactive oxygen speciesDNA repair pathwaysOverview of proinflammatory and profibrotic mediatorsDNA damage response Sustaining proliferative signalingDamaged BER pathwayIncreased recruitment of inflammatory cells Genomic instabilityMesothelial cell proliferationMesotheliomaIncreased DNA damage and mutationCell CycleDamaged NER pathwayEvading growth suppressorsTumor suppressor gene mutationsResisting cell deathApoptosis pathway mutationsInducing angiogenesisNeovascularization processesActivating invasion and metastasisMetastasis and epithelial-to-mesenchymal transitionDeregulating cellular energeticsTCA Cycle Nutrient use in cancerDeregulating cellular energeticsImmune infiltrationT cell modulationNonmutational epigenetic reprogrammingNonmutational epigenetic reprogramming


Description

Adverse Outcome Pathway for malignant pleural mesothelioma, known to be initiated by asbestos and carbon nanotubes. This molecular AOP is based on https://aopwiki.org/aops/409

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Ontology Terms

 

Bibliography

  1. Akio Kuroda; ''Recent progress and perspectives on the mechanisms underlying Asbestos toxicity''; , 2021 PubMed Europe PMC Scholia
  2. Gupta SS, Singh KP, Gupta S, Dusinska M, Rahman Q; ''Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?''; Nanomaterials (Basel), 2022 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134123view07:53, 25 June 2024PhilipErnstchanged one key event to match Hallmarks of cancer
134110view11:16, 20 June 2024PhilipErnstchanged one linked pathway
134090view12:04, 13 June 2024Marvin M2connected line and removed AO pathway
134089view11:07, 13 June 2024PhilipErnstUpdated with hallmarks of cancer
129340view09:18, 27 March 2024MkutmonOntology Term : 'disease pathway' added !
124069view12:18, 15 September 2022Marvin M2Modified title
124068view12:18, 15 September 2022Marvin M2Modified description
124067view12:15, 15 September 2022Marvin M2Added references
123058view11:45, 22 June 2022Alexandraboschswitched Key Event
122802view12:21, 18 May 2022Alexandraboschfixed connection between Increased DNA damage and Genomic instability
122666view10:16, 28 April 2022Alexandraboschaddition of NRF2 pathway node
122653view10:14, 26 April 2022Alexandraboschadded KE IDs
122652view10:07, 26 April 2022Alexandraboschfixed layout
122651view10:04, 26 April 2022Alexandraboschaddition of pathway nodes
122650view09:32, 26 April 2022Alexandraboschadapted according to AOP-Wiki
122638view13:10, 24 April 2022Alexandraboschadded KE ID for oxidative stress, DNA double strand breaks, increased mutation, chromosome breaks and rearrangement & Mesothelioma
122637view12:57, 24 April 2022Alexandraboschadded KE ID for mesothelial cell proliferation
122589view15:04, 19 April 2022Marvin M2added KE ID for genomic instability
118961view10:48, 5 June 2021EweitzOntology Term : 'mesothelial cell' added !
116743view15:48, 11 May 2021Marvin M2Ontology Term : 'malignant pleural mesothelioma' added !
116742view15:48, 11 May 2021Marvin M2Modified description
116741view15:40, 11 May 2021Marvin M2Added KE pathway
116328view15:05, 30 April 2021Marvin M2New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Activating invasion and metastasis
Apoptosis pathway mutationsPathwayWP1772 (WikiPathways)
Cell CyclePathwayWP179 (WikiPathways)
Cell cycle checkpoints PathwayWP1775 (WikiPathways)
DNA damage response PathwayWP707 (WikiPathways)
DNA repair pathwaysPathwayWP4946 (WikiPathways)
Damaged BER pathwayPathwayWP4752 (WikiPathways)
Damaged NER pathwayPathwayWP4753 (WikiPathways)
Deregulating cellular energetics
Evading growth suppressors
Frustrated phagocytosisKey Event1668 (AOP-Wiki KE)
Genomic instabilityKey Event1896 (AOP-Wiki KE)
HoC: Sustaining proliferative signallingPathwayWP5475 (WikiPathways)
Immune infiltrationPathwayWP5285 (WikiPathways)
Increased DNA damage and mutationKey Event1669 (AOP-Wiki KE)
Increased reactive oxygen speciesKey Event1115 (AOP-Wiki KE)
Increased recruitment of inflammatory cells Key Event1497 (AOP-Wiki KE)
Increased secretion of proinflammatory mediatorsKey Event1496 (AOP-Wiki KE)
Inducing angiogenesis
Mesothelial cell proliferationKey Event870 (AOP-Wiki KE)
MesotheliomaKey Event1090 (AOP-Wiki KE)
Metastasis and epithelial-to-mesenchymal transitionPathwayWP5469 (WikiPathways)
NRF2 pathwayPathwayWP2884 (WikiPathways)
Neovascularization processesPathwayWP4331 (WikiPathways)
Nonmutational epigenetic reprogramming
Nonmutational epigenetic reprogrammingPathwayWP5483 (WikiPathways)
Overview of proinflammatory and profibrotic mediatorsPathwayWP5095 (WikiPathways)
Oxidative damage response PathwayWP3941 (WikiPathways)
Resisting cell death
Sustaining proliferative signaling
T cell modulationPathwayWP5078 (WikiPathways)
TCA Cycle Nutrient use in cancerPathwayWP2868 (WikiPathways)
Tumor suppressor gene mutationsPathwayWP1742 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5091"
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