Heme biosynthesis (Canis familiaris)

From WikiPathways

Revision as of 10:54, 21 May 2021 by Eweitz (Talk | contribs)
Jump to: navigation, search
delta-aminolevulinatedelta-aminolevulinateFe2+Red - side productsH+succinyl-CoA + glycineBlack - reactantsprotoporphyrinogen IXrate limiting stepO2UROSCO2coproporphyrinogen IIICPOXH2OCO2URODH2O2ALAS1PorphobilinogenALADNH3FECHuroporphyrinogen IIIH2OO2CoAporphobilinogenprotohemeALAS2protoporphyrin IXPPOXHMBSCO2H2Ohydroxymethylbilane


Description

The enzymatic process that produces heme is properly called porphyrin synthesis, as all the intermediates are tetrapyrroles that are chemically classified are porphyrins. The process is highly conserved across biology. In humans, this pathway serves almost exclusively to form heme. In other species, it also produces similar substances such as cobalamin (vitamin B12).

The pathway is initiated by the synthesis of D-Aminolevulinic acid (dALA or δALA) from the amino acid glycine and succinyl-CoA from the citric acid cycle (Krebs cycle). The rate-limiting enzyme responsible for this reaction, ALA synthase, is strictly regulated by intracellular iron levels and heme concentration. A low-iron level, e.g., in iron deficiency, leads to decreased porphyrin synthesis, which prevents accumulation of the toxic intermediates. This mechanism is of therapeutic importance: infusion of heme arginate or hematin can abort attacks of porphyria in patients with an inborn error of metabolism of this process, by reducing transcription of ALA synthase.

The organs mainly involved in heme synthesis are the liver and the bone marrow, although every cell requires heme to function properly. Heme is seen as an intermediate molecule in catabolism of haemoglobin in the process of bilirubin metabolism.

Source: Wikipedia http://en.wikipedia.org/wiki/Heme

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP561(r21860) with a 53% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
134196view18:28, 16 July 2024EgonwRemoved template comments
117457view10:54, 21 May 2021EweitzModified title
106030view11:55, 16 August 2019MaintBotHMDB identifier normalization
89920view13:33, 6 October 2016MkutmonModified description
88636view14:50, 12 August 2016JmeliusOntology Term : 'heme biosynthetic pathway' added !
71972view00:16, 24 October 2013MaintBotremoved data source from nodes without identifier
70006view23:34, 11 July 2013MaintBotupdated to 2013 schema
40670view21:49, 1 March 2011MaintBotRemoved redundant pathway information and comments
35293view22:54, 11 February 2010Mills42Modified description
33961view18:25, 9 December 2009MaintBotAutomatic update of empty xrefs
31719view11:54, 14 August 2009MaintBotFixed group labels
30655view22:35, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ALADGeneProduct474808 (Entrez Gene)
ALAS1GeneProduct476600 (Entrez Gene)
ALAS2GeneProduct491498 (Entrez Gene)
CO2MetaboliteHMDB0001967 (HMDB)
CPOXGeneProduct
CoAMetaboliteHMDB0001423 (HMDB)
FECHGeneProduct610360 (Entrez Gene)
H2O2MetaboliteHMDB0003125 (HMDB)
H2OMetaboliteHMDB0002111 (HMDB)
HMBSGeneProduct489373 (Entrez Gene)
NH3MetaboliteHMDB0000051 (HMDB)
O2MetaboliteHMDB0001377 (HMDB)
PPOXGeneProduct478980 (Entrez Gene)
PorphobilinogenMetaboliteHMDB0000245 (HMDB)
URODGeneProduct475378 (Entrez Gene)
UROSGeneProduct492116 (Entrez Gene)
coproporphyrinogen IIIMetabolite
hydroxymethylbilaneMetabolite
porphobilinogenMetabolite
protohemeMetabolite
protoporphyrin IXMetabolite
uroporphyrinogen IIIMetabolite

Annotated Interactions

No annotated interactions
Personal tools