Interferon type I signaling (Homo sapiens)
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Description
The type I IFNs (IFNα family, IFNβ, IFNω, IFNε and IFNκ) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other accessory proteins. The pathway above (WP585) describes the Type I Interferon signaling pathways and shows both classical IFN signaling via the JAK-STAT pathway (dark lines) and other non-canonical IFN signaling pathways.
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Bibliography
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- Uddin S, Yenush L, Sun XJ, Sweet ME, White MF, Platanias LC; ''Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
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- Uddin S, Sher DA, Alsayed Y, Pons S, Colamonici OR, Fish EN, White MF, Platanias LC; ''Interaction of p59fyn with interferon-activated Jak kinases.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC Scholia
- Samarajiwa SA, Mangan NE, Hardy MP, Najdovska M, Dubach D, Braniff SJ, Owczarek CM, Hertzog PJ; ''Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4-mediated septic shock.''; J Immunol, 2014 PubMed Europe PMC Scholia
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- Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR; ''Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
- Ahmad S, Alsayed YM, Druker BJ, Platanias LC; ''The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
- Uddin S, Majchrzak B, Woodson J, Arunkumar P, Alsayed Y, Pine R, Young PR, Fish EN, Platanias LC; ''Activation of the p38 mitogen-activated protein kinase by type I interferons.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
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- Novick D, Cohen B, Rubinstein M; ''The human interferon alpha/beta receptor: characterization and molecular cloning.''; Cell, 1994 PubMed Europe PMC Scholia
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