Male steroid hormones in cardiomyocyte energy metabolism (Homo sapiens)

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22, 42CardiomyocyteNucleus43, 4AKR1C3testosterone3β-HSD23β-HSDoestradiolcholesterolCYP11A1HSD3B1CYP17A1(C17,20-lyase)HSD17B3Testosterone glucuronideHSD3B217β-HSD5β-Dihydro-testosterone3β-Eticholane-diolTestosterone-sulfateprogesterone17a Hydroxypregnenolone3α-HSD3α-Androstane-diol17β-HSDHSD17B3EpiandrosteroneHSD17B33β-HSDCYP17A1(17α-hydroxylase)Androgen Receptor (AR)EpietiocholanoloneestroneSRD5A13α-Etiocholane-diolEtiocholanoloneAromataseHSD3B2HSD3B1AKR1C3 17β-HSD3α-HSDSulfotransferaseAndrostenedioneHSD17B2HSD17B217β-HSDSRD5A25α-Dihydro-testosterone17β-HSDAromatase3β-Androstane-diolGlucuronosyl-transferaseAndrostanedioneSRD5A1/5α-reductaseandrostenediolpregnenoloneDHEAandrosteroneSRD5A2/5β-reductaseAKR1C311, 2, 41, 4241, 2, 41, 41, 421, 2, 42, 41, 421, 42, 431, 421, 4422, 421, 2, 4


Description

This pathway depicts the effect of testosterone and androstanedione on energy metabolism in cardiomyocytes.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Carbajal-García A, Reyes-García J, Montaño LM; ''Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes.''; Int J Endocrinol, 2020 PubMed Europe PMC Scholia
  2. Ishizaki F, Nishiyama T, Kawasaki T, Miyashiro Y, Hara N, Takizawa I, Naito M, Takahashi K; ''Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer.''; Sci Rep, 2013 PubMed Europe PMC Scholia
  3. Davey RA, Grossmann M; ''Androgen Receptor Structure, Function and Biology: From Bench to Bedside.''; Clin Biochem Rev, 2016 PubMed Europe PMC Scholia
  4. McEwan IJ, Brinkmann AO; ''Androgen Physiology: Receptor and Metabolic Disorders.''; , 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134471view00:47, 22 July 2024EweitzModified description
134470view00:46, 22 July 2024EweitzOntology Term : 'cardiac muscle cell' added !
125916view22:07, 17 March 2023EgonwMore fixed HMDB identifiers
125914view19:12, 17 March 2023EgonwNew HMDB format
125912view18:45, 17 March 2023EgonwUpdated the UniProt data sources
125903view13:59, 17 March 2023JmillanacostaAdded identifier
125868view17:27, 14 March 2023Bhavanakapalliidentifiers added
125623view20:02, 5 March 2023AlexanderPicoModified description
125617view11:38, 5 March 2023EgonwCorrect PubChem identifier (was for a silicon derivative)
125616view11:34, 5 March 2023EgonwRemoved duplicate reference info
125552view21:42, 26 February 2023AndraOntology Term : 'classic metabolic pathway' added !
125254view20:56, 30 January 2023Bhavanakapalliidentifiers
125253view20:53, 30 January 2023Bhavanakapalliidentifiers
125220view10:07, 30 January 2023BhavanakapalliReverted to version '10:05, 30 January 2023' by Bhavanakapalli
125219view10:06, 30 January 2023BhavanakapalliReverted to version '16:44, 29 January 2023' by Bhavanakapalli
125218view10:05, 30 January 2023Bhavanakapalli
125210view16:44, 29 January 2023Isissampermans
125209view16:42, 29 January 2023Isissampermans
125208view16:41, 29 January 2023Isissampermans
125207view16:39, 29 January 2023IsissampermansAddition of nucleus and cell structures
125205view15:53, 29 January 2023Isissampermans
125204view15:50, 29 January 2023IsissampermansNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
17a HydroxypregnenoloneMetaboliteHMDB0000363 (HMDB)
17β-HSDProteinCHEMBL4234 (EMBL)
17β-HSDProteinQ9BPX1 (Uniprot-TrEMBL)
3α-Androstane-diolMetabolite5879 (PubChem-compound)
3α-Etiocholane-diolMetabolite5880 (PubChem-compound)
3α-HSDProteinP80701 (Uniprot-TrEMBL)
3β-Androstane-diolMetabolite441302 (PubChem-compound)
3β-Eticholane-diolMetabolite247732 (PubChem-compound)
3β-HSD2GeneProductP26439 (Uniprot-TrEMBL)
3β-HSDProteinQ9N119 (Uniprot-TrEMBL)
5α-Dihydro-testosteroneMetabolite10635 (PubChem-compound)
5β-Dihydro-testosteroneMetabolite11302 (PubChem-compound)
AKR1C3 ProteinA0A0A0MSS8 (Uniprot-TrEMBL)
AKR1C3GeneProductA0A0A0MSS8 (Uniprot-TrEMBL)
Androgen Receptor (AR)MetaboliteHMDB0001624 (HMDB)
AndrostanedioneMetaboliteHMDB0000053 (HMDB)
AndrostenedioneMetaboliteHMDB0000053 (HMDB)
AromataseProteinP11511 (Uniprot-TrEMBL)
CYP11A1ProteinP05108 (Uniprot-TrEMBL)
CYP17A1 (17α-hydroxylase)ProteinP05093 (Uniprot-TrEMBL)
CYP17A1 (C17,20-lyase)ProteinP05093 (Uniprot-TrEMBL)
DHEAMetaboliteCHEBI:28689 (ChEBI)
EpiandrosteroneMetaboliteHMDB0000365 (HMDB)
EpietiocholanoloneMetaboliteHMDB0000546 (HMDB)
EtiocholanoloneMetaboliteHMDB0000490 (HMDB)
Glucuronosyl- transferaseProteinP22309 (Uniprot-TrEMBL)
HSD17B2ProteinP37059 (Uniprot-TrEMBL)
HSD17B3GeneProductP37058 (Uniprot-TrEMBL)
HSD3B1GeneProductENSG00000203857.10 (Ensembl)
HSD3B1GeneProductP14060 (Uniprot-TrEMBL)
HSD3B2GeneProductENSG00000203859.10 (Ensembl)
HSD3B2GeneProductP26439 (Uniprot-TrEMBL)
SRD5A1/5α-reductaseGeneProductP18405 (Uniprot-TrEMBL)
SRD5A1GeneProductENSG00000145545.12 (Ensembl)
SRD5A2/5β-reductaseGeneProductP31213 (Uniprot-TrEMBL)
SRD5A2GeneProductENSG00000277893.2 (Ensembl)
SulfotransferaseProteinP50225 (Uniprot-TrEMBL)
Testosterone glucuronideMetaboliteCHEBI:28835 (ChEBI)
Testosterone-sulfateMetabolite119207 (PubChem-compound)
androstenediolMetaboliteQ2817108 (Wikidata)
androsteroneMetaboliteQ422469 (Wikidata)
cholesterolMetaboliteCHEBI:16113 (ChEBI)
estroneMetaboliteCHEBI:17263 (ChEBI)
oestradiolMetaboliteCHEBI:23965 (ChEBI)
pregnenoloneMetaboliteCHEBI:16581 (ChEBI)
progesteroneMetaboliteCHEBI:17026 (ChEBI)
testosteroneMetaboliteCHEBI:17347 (ChEBI)

Annotated Interactions

No annotated interactions

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