Ganglio series sphingolipid metabolism (Homo sapiens)

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3, 456GD2GM3ST8SIA5ST3GAL2B3GALT4GM1bGT3HEXAST3GAL4GM2GM1GQ1cGA1/ Asialo-GM1GD1aGD3B4GALNT1GT1cGT2GM2aGA2ST8SIA1GT1aGQ1bGP1cST8SIA6HEXBGD1cB3GALT4NEU4NEU31NEU41LacCerNEU3B4GALNT1ST3GAL5ST3GAL2ST3GAL1ST3GAL4GD1bGT1bST8SIA1ST8SIA5ST8SIA5ST8SIA1ST8SIA5


Description

Ganglio- series of glycosphingolipids, biosynthesis

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Ontology Terms

 

Bibliography

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  1. Yamaguchi K, Hata K, Koseki K, Shiozaki K, Akita H, Wada T, Moriya S, Miyagi T; ''Evidence for mitochondrial localization of a novel human sialidase (NEU4).''; Biochem J, 2005 PubMed Europe PMC Scholia
  2. Yamashiro S, Haraguchi M, Furukawa K, Takamiya K, Yamamoto A, Nagata Y, Lloyd KO, Shiku H; ''Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  3. Merril AH Jr; ''SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids.''; Glycobiology, 2005 PubMed Europe PMC Scholia
  4. Inokuchi, J-I, Go, S; ''Map 3: Biosynthetic Pathways of Glycosphingolipids''; https://doi.org/10.1007/978-4-431-54240-7_162, 2014 DOI Scholia
  5. Nakayama J, Fukuda MN, Hirabayashi Y, Kanamori A, Sasaki K, Nishi T, Fukuda M; ''Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  6. Amado M, Almeida R, Carneiro F, Levery SB, Holmes EH, Nomoto M, Hollingsworth MA, Hassan H, Schwientek T, Nielsen PA, Bennett EP, Clausen H; ''A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family.''; J Biol Chem, 1998 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134480view01:07, 22 July 2024EweitzOntology Term : 'sphingolipid metabolic pathway' added !
134479view01:07, 22 July 2024EweitzOntology Term : 'lipid metabolic pathway' added !
125333view22:30, 31 January 2023LarsgwAdd DOI to reference
125165view01:38, 26 January 2023AlexanderPicofixed PublicationXref
125130view16:37, 24 January 2023Conroy lipidsupdae citation
125118view09:20, 24 January 2023Conroy lipidsadded ECs
124529view13:31, 4 November 2022Conroy lipids
124528view13:30, 4 November 2022Conroy lipidsfettling, some more data
124525view12:40, 4 November 2022Conroy lipidsmore lipids, reactions etc
124511view16:21, 3 November 2022Conroy lipids
124510view16:01, 3 November 2022Conroy lipidsadd more steps- remain blanks and things to check
124505view14:34, 3 November 2022Conroy lipidsadd GM1
124501view18:55, 2 November 2022Conroy lipids
124500view18:53, 2 November 2022Conroy lipidsOntology Term : 'ganglioside metabolic pathway' added !
124499view18:51, 2 November 2022Conroy lipidsNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
B3GALT4GeneProductO96024 (Uniprot-TrEMBL)
B4GALNT1GeneProductQ00973 (Uniprot-TrEMBL)
GA1/ Asialo-GM1MetaboliteLMSP0503AB00 (LIPID MAPS)
GA2MetaboliteLMSP0503AA00 (LIPID MAPS)
GD1aMetaboliteLMSP0601AS00 (LIPID MAPS)
GD1bMetaboliteLMSP0601AQ00 (LIPID MAPS)
GD1cMetaboliteLMSP0601BN00 (LIPID MAPS)
GD2MetaboliteLMSP0601AN00 (LIPID MAPS)
GD3MetaboliteLMSP0601AK00 (LIPID MAPS)
GM1MetaboliteLMSP0601AP00 (LIPID MAPS)
GM1bMetaboliteLMSP0601AY00 (LIPID MAPS)
GM2MetaboliteLMSP0601AM00 (LIPID MAPS)
GM2aMetaboliteLMSP0601EK00 (LIPID MAPS)
GM3MetaboliteLMSP0601AJ00 (LIPID MAPS)
GP1cMetaboliteLMSP0601AX00 (LIPID MAPS)
GQ1bMetaboliteLMSP0601AV00 (LIPID MAPS)
GQ1cMetaboliteLMSP0601AU00 (LIPID MAPS)
GT1aMetaboliteLMSP0601AW00 (LIPID MAPS)
GT1bMetaboliteLMSP0601AT00 (LIPID MAPS)
GT1cMetaboliteLMSP0601AR00 (LIPID MAPS)
GT2MetaboliteLMSP0601AO00 (LIPID MAPS)
GT3MetaboliteLMSP0601AL00 (LIPID MAPS)
HEXAGeneProductP06865 (Uniprot-TrEMBL)
HEXBGeneProductP07686 (Uniprot-TrEMBL)
LacCerMetaboliteLMSP0501AB00 (LIPID MAPS)
NEU3GeneProductQ9UQ49 (Uniprot-TrEMBL)
NEU4GeneProductQ8WWR8 (Uniprot-TrEMBL)
ST3GAL1GeneProductQ11201 (Uniprot-TrEMBL)
ST3GAL2GeneProductQ16842 (Uniprot-TrEMBL)
ST3GAL4GeneProductQ11206 (Uniprot-TrEMBL)
ST3GAL5GeneProductQ9UNP4 (Uniprot-TrEMBL)
ST8SIA1GeneProductQ92185 (Uniprot-TrEMBL)
ST8SIA5GeneProductO15466 (Uniprot-TrEMBL)
ST8SIA6GeneProductP61647 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
GA1/ Asialo-GM1GM1bmim-conversion47561 (Rhea) EC:2.4.3.2
GA2GA1/ Asialo-GM1mim-conversion41961 (Rhea) EC:2.4.1.62
GA2LacCermim-conversion48453 (Rhea)
GD1aGT1amim-conversion41769 (Rhea)
GD1bGT1bmim-conversion47573 (Rhea) EC:2.4.3.4
GD2GD1bmim-conversion47569 (Rhea) EC:2.4.1.62
GD3GD2mim-conversion43273 (Rhea) EC:2.4.1.92
GD3GM3mim-conversion48125 (Rhea) EC:3.2.1.18
GD3GT3mim-conversion41765 (Rhea)
GM1GD1amim-conversion18022 (Rhea) EC:2.4.3.2
GM1bGD1cmim-conversion47577 (Rhea)
GM2GM1mim-conversion16774 (Rhea) EC:2.4.1.62
GM2GM3mim-conversion47941 (Rhea) EC:3.2.1.52
GM3GD3mim-conversion48289 (Rhea)
GM3GM2mim-conversion12589 (Rhea) EC:2.4.1.92
GM3LacCermim-conversion47901 (Rhea) EC:3.2.1.18
GP1cGQ1cmim-conversion48529 (Rhea)
GQ1bGT1bmim-conversion48157 (Rhea)
GQ1cGP1cmim-conversion47593 (Rhea)
GQ1cGT1cmim-conversion48533 (Rhea)
GT1bGD1bmim-conversion47861 (Rhea)
GT1bGQ1bmim-conversion41773 (Rhea)
GT1cGQ1cmim-conversion47589 (Rhea) EC:2.4.3.2
GT2GT1cmim-conversion47585 (Rhea)
GT3GT2mim-conversion47581 (Rhea) EC:2.4.1.92
LacCerGA2mim-conversion47565 (Rhea) EC:2.4.1.92
LacCerGM3mim-conversion18418 (Rhea) EC:2.4.3.9
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