Thyroid hormone imbalance leading to neurodevelopmental abnormalities (Homo sapiens)

From WikiPathways

Revision as of 17:07, 28 January 2024 by Eweitz (Talk | contribs)
Jump to: navigation, search
BrainThyroid hormone production1, 2Thyroid hormone biosynthesis pathwayKE279: Thyroperoxidase inhibition KE1656: Thyroid receptor antagonismKE424: NIS inhibition KE277: Decrease thyroid hormone synthesis KE425: Decrease of thyroidal iodideKE281: Decreased T4 in serumKE381: Reduced levels of BDNF BDNF signaling pathwayKE280: Decreased T4 in neuronal tissue KE756: Altered hippocampal gene expression Hippocampal synaptogenesis and neurogenesisKE851: Decreased GABAergic interneurons GABA receptor signaling pathwayKE757: Altered hippocampal anatomy KE758: Altered hippocampal physiology KE385: Decreased synaptogenesis KE386: Decreased neuronal network functionHippocampal synaptogenesis and neurogenesisKE341: Learning and memory impairment KE42: Decreased cognitive function KE319: loss of cochlear functionThyroid hormone biosynthesis pathwayThyroid hormone biosynthesis pathwayKE2104: Decreased binding TH to thyroid receptorKE2105: Decreased myelin basic protein expression in oligodendrocytesKE2106: Impaired oligodendrocyte maturationKE2107: HypomyelinationOligodendrocyte specification and differentiation, leading to myelin components for CNSOligodendrocyte specification and differentiation, leading to myelin components for CNSOligodendrocyte specification and differentiation, leading to myelin components for CNSKE2108: Altered white brain matter


Description

Adverse outcome pathway for the effect of thyroid hormone disruption. This AOP network is based on the human-relevant AOPs in AOP-Wiki that involve thyroid hormone and neurological adverse outcomes.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Sauer UG, Asiimwe A, Botham PA, Charlton A, Hallmark N, Jacobi S, Marty S, Melching-Kollmuss S, Palha JA, Strauss V, van Ravenzwaay B, Swaen G; ''Toward a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part I: which parameters from human studies are most relevant for toxicological assessments?''; Crit Rev Toxicol, 2020 PubMed Europe PMC Scholia
  2. Marty S, Beekhuijzen M, Charlton A, Hallmark N, Hannas BR, Jacobi S, Melching-Kollmuss S, Sauer UG, Sheets LP, Strauss V, Urbisch D, Botham PA, van Ravenzwaay B; ''Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part II: how can key events of relevant adverse outcome pathways be addressed in toxicological assessments?''; Crit Rev Toxicol, 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134542view21:16, 22 July 2024EweitzOntology Term : 'oligodendrocyte' added !
134541view21:16, 22 July 2024EweitzOntology Term : 'GABAergic interneuron' added !
134540view21:15, 22 July 2024EweitzOntology Term : 'thyroid hormone biosynthetic pathway' added !
134539view18:35, 22 July 2024EgonwFixed a datasource
128159view17:07, 28 January 2024EweitzModified description
128158view17:06, 28 January 2024EweitzRefine node padding, add space after colons, standardize case
128157view17:02, 28 January 2024EweitzModified title
127806view21:23, 17 December 2023Marvin M2Modified description
127805view21:22, 17 December 2023Marvin M2
127804view21:18, 17 December 2023Marvin M2graphical updates
127291view14:34, 4 September 2023Marvin M2Updated layout, added chain of KEs
126475view17:27, 4 May 2023CMalyarModified title
125574view13:23, 28 February 2023Marvin M2Added references
125573view13:19, 28 February 2023Marvin M2Ontology Term : 'thyroid hormone signaling pathway' added !
124846view21:03, 14 December 2022EweitzModified title
124834view19:38, 13 December 2022Marvin M2
124833view19:36, 13 December 2022Marvin M2alignment changes
122991view13:39, 10 June 2022CMalyarFixed interactions
122990view14:06, 9 June 2022CMalyarPathway interactions fixed
122989view14:04, 9 June 2022CMalyarFixed interaction arrows
122983view08:01, 9 June 2022CMalyarManual identifiers of key events from AOP-Wiki
122980view20:03, 8 June 2022CMalyarFixed pathway identifiers
122979view19:57, 8 June 2022CMalyarStructural changes
122671view07:59, 29 April 2022CMalyar
122655view12:58, 26 April 2022CMalyar
122654view11:03, 26 April 2022CMalyarNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BDNF signaling pathwayPathwayWP2380 (WikiPathways)
GABA receptor signaling pathwayPathwayWP4159 (WikiPathways)
Hippocampal synaptogenesis and neurogenesisPathwayWP5231 (WikiPathways)
KE1656: Thyroid receptor antagonismKey Event1656 (AOP-Wiki KE)
KE2104: Decreased binding TH to thyroid receptorKey Event2104 (AOP-Wiki KE)
KE2105: Decreased myelin basic protein expression in oligodendrocytesKey Event2105 (AOP-Wiki KE)
KE2106: Impaired oligodendrocyte maturationKey Event2106 (AOP-Wiki KE)
KE2107: HypomyelinationKey Event2107 (AOP-Wiki KE)
KE2108: Altered white brain matterKey Event2108 (AOP-Wiki KE)
KE277: Decrease thyroid hormone synthesis Key Event277 (AOP-Wiki KE)
KE279: Thyroperoxidase inhibition Key Event279 (AOP-Wiki KE)
KE280: Decreased T4 in neuronal tissue Key Event280 (AOP-Wiki KE)
KE281: Decreased T4 in serumKey Event281 (AOP-Wiki KE)
KE319: loss of cochlear functionKey Event319 (AOP-Wiki KE)
KE341: Learning and memory impairment Key Event341 (AOP-Wiki KE)
KE381: Reduced levels of BDNF Key Event381 (AOP-Wiki KE)
KE385: Decreased synaptogenesis Key Event385 (AOP-Wiki KE)
KE386: Decreased neuronal network functionKey Event386 (AOP-Wiki KE)
KE424: NIS inhibition Key Event424 (AOP-Wiki KE)
KE425: Decrease of thyroidal iodideKey Event425 (AOP-Wiki KE)
KE42: Decreased cognitive function Key Event42 (AOP-Wiki KE)
KE756: Altered hippocampal gene expression Key Event756 (AOP-Wiki KE)
KE757: Altered hippocampal anatomy Key Event757 (AOP-Wiki KE)
KE758: Altered hippocampal physiology Key Event758 (AOP-Wiki KE)
KE851: Decreased GABAergic interneurons Key Event851 (AOP-Wiki KE)
Oligodendrocyte specification and differentiation, leading to myelin components for CNSPathwayWP4304 (WikiPathways)
Thyroid hormone biosynthesis pathway PathwayWP1981 (WikiPathways)

Annotated Interactions

No annotated interactions

Personal tools