Thyroid hormone imbalance leading to neurodevelopmental abnormalities (Homo sapiens)
From WikiPathways
Description
Adverse outcome pathway for the effect of thyroid hormone disruption. This AOP network is based on the human-relevant AOPs in AOP-Wiki that involve thyroid hormone and neurological adverse outcomes.
Quality Tags
Ontology Terms
Bibliography
- Sauer UG, Asiimwe A, Botham PA, Charlton A, Hallmark N, Jacobi S, Marty S, Melching-Kollmuss S, Palha JA, Strauss V, van Ravenzwaay B, Swaen G; ''Toward a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part I: which parameters from human studies are most relevant for toxicological assessments?''; Crit Rev Toxicol, 2020 PubMed Europe PMC Scholia
- Marty S, Beekhuijzen M, Charlton A, Hallmark N, Hannas BR, Jacobi S, Melching-Kollmuss S, Sauer UG, Sheets LP, Strauss V, Urbisch D, Botham PA, van Ravenzwaay B; ''Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part II: how can key events of relevant adverse outcome pathways be addressed in toxicological assessments?''; Crit Rev Toxicol, 2021 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
BDNF signaling pathway | Pathway | WP2380 (WikiPathways) | |
GABA receptor signaling pathway | Pathway | WP4159 (WikiPathways) | |
Hippocampal synaptogenesis and neurogenesis | Pathway | WP5231 (WikiPathways) | |
KE1656: Thyroid receptor antagonism | Key Event | 1656 (AOP-Wiki KE) | |
KE2104: Decreased binding TH to thyroid receptor | Key Event | 2104 (AOP-Wiki KE) | |
KE2105: Decreased myelin basic protein expression in oligodendrocytes | Key Event | 2105 (AOP-Wiki KE) | |
KE2106: Impaired oligodendrocyte maturation | Key Event | 2106 (AOP-Wiki KE) | |
KE2107: Hypomyelination | Key Event | 2107 (AOP-Wiki KE) | |
KE2108: Altered white brain matter | Key Event | 2108 (AOP-Wiki KE) | |
KE277: Decrease thyroid hormone synthesis | Key Event | 277 (AOP-Wiki KE) | |
KE279: Thyroperoxidase inhibition | Key Event | 279 (AOP-Wiki KE) | |
KE280: Decreased T4 in neuronal tissue | Key Event | 280 (AOP-Wiki KE) | |
KE281: Decreased T4 in serum | Key Event | 281 (AOP-Wiki KE) | |
KE319: loss of cochlear function | Key Event | 319 (AOP-Wiki KE) | |
KE341: Learning and memory impairment | Key Event | 341 (AOP-Wiki KE) | |
KE381: Reduced levels of BDNF | Key Event | 381 (AOP-Wiki KE) | |
KE385: Decreased synaptogenesis | Key Event | 385 (AOP-Wiki KE) | |
KE386: Decreased neuronal network function | Key Event | 386 (AOP-Wiki KE) | |
KE424: NIS inhibition | Key Event | 424 (AOP-Wiki KE) | |
KE425: Decrease of thyroidal iodide | Key Event | 425 (AOP-Wiki KE) | |
KE42: Decreased cognitive function | Key Event | 42 (AOP-Wiki KE) | |
KE756: Altered hippocampal gene expression | Key Event | 756 (AOP-Wiki KE) | |
KE757: Altered hippocampal anatomy | Key Event | 757 (AOP-Wiki KE) | |
KE758: Altered hippocampal physiology | Key Event | 758 (AOP-Wiki KE) | |
KE851: Decreased GABAergic interneurons | Key Event | 851 (AOP-Wiki KE) | |
Oligodendrocyte specification and differentiation, leading to myelin components for CNS | Pathway | WP4304 (WikiPathways) | |
Thyroid hormone biosynthesis pathway | Pathway | WP1981 (WikiPathways) |
Annotated Interactions
No annotated interactions